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Nox1 - NADPH oxidase 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 114243

About Nox1

Primary_assembly X: 97,279,056-97,302,236 reverse strand.mRatBN7.2:CM026994.1

This gene has 5 transcripts (splice variants), 126 orthologues, 5 paralogues and is associated with 8 phenotypes. Biased expression in Brain (RPKM 13.3), Thymus (RPKM 12.8) and 9 other tissues.

Summary

Enables NAD(P)H oxidase H2O2-forming activity. Involved in several processes, including positive regulation of Reactive Oxygen Species metabolic process; positive regulation of smooth muscle cell proliferation; and superoxide anion generation. Part of NADPH Oxidase complex. Orthologous to human NOX1 (NADPH Oxidase 1). [provided by Alliance of Genome Resources, Apr 2022]

Nox1 Products (1)

mRNA	Protein	Name
NM_053683.2	NP_446135.2	NADPH oxidase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables NAD(P)H oxidase H2O2-forming activity	IMP IMP: Inferred from mutant phenotype	28317735	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15322091	RGD
enables superoxide-generating NAD(P)H oxidase activity	IDA IDA: Inferred from direct assay	10485709	RGD
enables superoxide-generating NAD(P)H oxidase activity	IMP IMP: Inferred from mutant phenotype	25228390	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cell chemotaxis	IMP IMP: Inferred from mutant phenotype	20018867	RGD
involved in cellular response to angiotensin	IEP IEP: Inferred from expression pattern	26682942	RGD
involved in cellular response to interleukin-1	IEP IEP: Inferred from expression pattern	26682942	RGD
involved in cellular response to mercury ion	IEP IEP: Inferred from expression pattern	28935286	RGD
involved in cellular response to platelet-derived growth factor stimulus	IEP IEP: Inferred from expression pattern	23706097	RGD
involved in glutathione metabolic process	IMP IMP: Inferred from mutant phenotype	30653821	RGD
involved in negative regulation of neuron maturation	IMP IMP: Inferred from mutant phenotype	25617620	RGD
involved in positive regulation of inclusion body assembly	IMP IMP: Inferred from mutant phenotype	23077033	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	25617620	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	33081375	RGD
involved in positive regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	16254042	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	10485709	RGD
involved in positive regulation of superoxide anion generation	IMP IMP: Inferred from mutant phenotype	24294978	RGD
involved in positive regulation of vascular associated smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	23706097	RGD
involved in positive regulation of vascular associated smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	23706097	RGD
involved in response to reactive oxygen species	IDA IDA: Inferred from direct assay	11832489	RGD
involved in superoxide anion generation	IMP IMP: Inferred from mutant phenotype	10485709	RGD

Cellular Component GO Annotation	Evidence	References	Source
part of NADPH oxidase complex	IDA IDA: Inferred from direct assay	15322091	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nox1 Protein Structure

Ferric_reduct

NOX_Duox_like_FAD_NADP

0
100
200
300
400
500
563 a.a.

Protein Preferred Names	Protein Names
NADPH oxidase 1	MOX-1 MOX1 NADH/NADPH mitogenic oxidase subunit p65-mox NOH-1 NOX-1 mitogenic oxidase 1

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0807A	Prochlorperazine dimaleate	Inhibitor	≥98.0%	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12298	Setanaxib	Inhibitor	99.81%	Phase 2
HY-120801	APX-115	Inhibitor	99.90%	Phase 2
HY-120801A	APX-115 free base	Inhibitor	99.54%	Phase 2

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12805	ML171	Inhibitor	99.53%	Unkown
HY-101499	GKT136901	Inhibitor	99.33%	Unkown
HY-P1435	NoxA1ds	Inhibitor	95.34%	Unkown
HY-126195	Fluoflavine	Inhibitor	98.47%	Unkown
HY-105946	Hidrosmin	Inhibitor	95.34%	Unkown
HY-P1435A	NoxA1ds TFA	Inhibitor	/	Unkown
HY-174818	NOX5-IN-2	Inhibitor	/	Unkown
HY-174817	NOX5-IN-1	Inhibitor	/	Unkown
HY-148936	GLX481372	Inhibitor	/	Unkown
HY-183101	AMPAR modulator-12	Inhibitor	/	Unkown
HY-124487	GK-136901	Inhibitor	/	Unkown
HY-128004	ML171 analog 1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nox1	NCBI	NCBI:27035