Nox1 - NADPH oxidase 1 Gene

Rattus norvegicus

Gene ID: 114243 | Gene type: protein coding

About Nox1

Primary_assembly X: 97,279,056-97,302,236 reverse strand.mRatBN7.2:CM026994.1

This gene has 5 transcripts (splice variants), 126 orthologues, 5 paralogues and is associated with 8 phenotypes. Biased expression in Brain (RPKM 13.3), Thymus (RPKM 12.8) and 9 other tissues.

Summary

Enables NAD(P)H oxidase H2O2-forming activity. Involved in several processes, including positive regulation of Reactive Oxygen Species metabolic process; positive regulation of smooth muscle cell proliferation; and superoxide anion generation. Part of NADPH Oxidase complex. Orthologous to human NOX1 (NADPH Oxidase 1). [provided by Alliance of Genome Resources, Apr 2022]

Nox1 Products(1)

mRNA	Protein	Name
NM_053683.2	NP_446135.2	NADPH oxidase 1

Nox1 Protein Structure

Ferric_reduct

NOX_Duox_like_FAD_NADP

0
100
200
300
400
500
563 a.a.

Protein Preferred Names

Protein Names

NADPH oxidase 1

MOX-1	MOX1
NADH/NADPH mitogenic oxidase subunit p65-mox	NOH-1
NOX-1	mitogenic oxidase 1

Related Agents

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12298	Setanaxib	Inhibitor	99.45%	Phase 3
HY-120801	APX-115	Inhibitor	99.58%	Phase 2
HY-120801A	APX-115 free base	Inhibitor	98.11%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12805	ML171	Inhibitor	99.82%	Unkown
HY-P1435	NoxA1ds	Inhibitor	95.21%	Unkown
HY-P1435A	NoxA1ds TFA	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nox1	NCBI	NCBI:27035

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