CGAS - cyclic GMP-AMP synthase Gene

Also Known as MB21D1; h-cGAS; C6orf150

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 115004

About CGAS

Cytogenetic location: 6q13 Genomic coordinates (GRCh38): 6:73,423,711-73,452,297 (from NCBI)

This gene has 4 transcripts (splice variants), 185 orthologues and 9 paralogues.

Summary

Enables several functions, including 2',3'-cyclic GMP-AMP synthase activity; chromatin binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including cellular response to exogenous dsRNA; positive regulation of intracellular signal transduction; and regulation of defense response. Located in several cellular components, including cytosol; nucleus; and site of double-strand break. [provided by Alliance of Genome Resources, Apr 2022]

CGAS Products (3)

mRNA	Protein	Name
NM_138441.3	NP_612450.2	cyclic GMP-AMP synthase isoform 1
XM_047418159.1	XP_047274115.1	cyclic GMP-AMP synthase isoform X1
NM_001410911.1	NP_001397840.1	cyclic GMP-AMP synthase isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 2',3'-cyclic GMP-AMP synthase activity	EXP EXP: Inferred from Experiment	23258412	GOA
enables 2',3'-cyclic GMP-AMP synthase activity	IDA IDA: Inferred from direct assay	23258413	GOA
enables DNA binding	IDA IDA: Inferred from direct assay	23258413	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	28738408	GOA
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	24077100	GOA
enables molecular condensate scaffold activity	IDA IDA: Inferred from direct assay	32911482	GOA
enables nucleosome binding	IDA IDA: Inferred from direct assay	32911482	GOA
enables phosphatidylinositol-4,5-bisphosphate binding	IDA IDA: Inferred from direct assay	30827685	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26046437	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	29426904	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	28738408	GOA
involved in activation of innate immune response	IDA IDA: Inferred from direct assay	23258413	GOA
involved in activation of innate immune response	IMP IMP: Inferred from mutant phenotype	23258413	GOA
involved in cAMP-mediated signaling	IDA IDA: Inferred from direct assay	23258413	GOA
involved in cGAS/STING signaling pathway	IDA IDA: Inferred from direct assay	32911482	GOA
involved in cGMP-mediated signaling	IDA IDA: Inferred from direct assay	23258413	GOA
involved in cytoplasmic pattern recognition receptor signaling pathway	IDA IDA: Inferred from direct assay	23258413	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	21478870	GOA
involved in innate immune response	IDA IDA: Inferred from direct assay	23258413	GOA
involved in negative regulation of cGAS/STING signaling pathway	IDA IDA: Inferred from direct assay	32911482	GOA
involved in negative regulation of double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	30356214	GOA
involved in paracrine signaling	IDA IDA: Inferred from direct assay	24077100	GOA
involved in pattern recognition receptor signaling pathway	IDA IDA: Inferred from direct assay	23258413	GOA
involved in positive regulation of defense response to virus by host	IDA IDA: Inferred from direct assay	23929945	GOA
involved in positive regulation of defense response to virus by host	IMP IMP: Inferred from mutant phenotype	23258413	GOA
involved in positive regulation of type I interferon production	IDA IDA: Inferred from direct assay	24077100	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	23258413	GOA
is active in cytosol	IDA IDA: Inferred from direct assay	32912999	GOA
located in cytosol	IDA IDA: Inferred from direct assay	23258413	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	38418882	GOA
located in nucleus	IDA IDA: Inferred from direct assay	29937271	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	30827685	GOA
located in site of double-strand break	IDA IDA: Inferred from direct assay	30356214	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CGAS Protein Structure

Mab-21

0
100
200
300
400
522 a.a.

Protein Preferred Names	Protein Names
cyclic GMP-AMP synthase	2'3'-cGAMP synthase Mab-21 domain containing 1 cGAMP synthase mab-21 domain-containing protein 1 protein MB21D1

Recombinant CGAS Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71597	cGAS Protein, Human (His-SUMO)	Q8N884-1 (G161-F522)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P72337	cGAS Protein, Human (His)	Q8N884-1 (M1-F522)	≥ 90%, as determined by reducing SDS-PAGE.

CGAS Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86195	cGAS Antibody (YA5887)	WB, IHC-P, ICC/IF, IP, ELISA	Mouse
HY-P86480	cGAS Antibody (YA6172)	WB, IHC-P, ICC/IF, IP, ELISA	Human

Related Diseases

Diseases	Alias
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Encephalopathy With Basal Ganglia Calcification Aicardi-Goutières Syndrome Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1
Covid-19	2019 Novel Coronavirus 2019-Ncov Infection Covid19 Sars-Cov-2 Infection Wuhan Coronavirus Infection Wuhan Seafood Market Pneumonia Virus Infection
Chilblain Lupus 1	Chilblain Lupus CHBL1 Chilblain Lupus Erythematosus Chle Hutchinson Lupus Chilblain Lupus, Type 1
Sting-Associated Vasculopathy With Onset In Infancy	Savi Sting-Associated Vasculopathy, Infantile Onset Sting-Associated Vasculopathy, Infantile-Onset
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Chikungunya	Chikungunya Fever Arbovirus A Chikungunya Type Chik Chikv Infection Ck Chikungunya Virus Infection Chikungunya Haemorrhagic Fever Chikungunya Viral Disease Chikungunya Mosquito-Borne Viral Fever
Vasculopathy, Retinal, With Cerebral Leukoencephalopathy And Systemic Manifestations	Crv Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations Rvcl Rvcl-S Vasculopathy, Retinal, With Cerebral Leukodystrophy Retinopathy, Vascular, With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena Retinal Vasculopathy With Cerebral Leukodystrophy Retinal Vasculopathy And Cerebral Leukoencephalopathy Hereditary Vascular Retinopathy Hvr RVCLS Cerebroretinal Vasculopathy, Hereditary Cerebroretinal Vasculopathy Herns Vasculopathy, Retinal, With Cerebral Leukodystrophy, Formerly Hereditary Cerebroretinal Vasculopathy Hereditary Endotheliopathy, Retinopathy, Nephropathy, Stroke Hereditary Systemic Angiopathy Hsa Retinal Vasculopathy With Cerebral Leukodystrophy With Systemic Manifestations Adrvcl Autosomal Dominant Retinal Vasculopathy With Cerebral Leukodystrophy Hereditary Endotheliopathy With Retinopathy-Nephropathy-Stroke Vascular Retinopathy With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena
Cutaneous Lupus Erythematosus	Lupus Erythematosus, Cutaneous Lupus Erythematosus Cutaneous
Huntington Disease	Huntington'S Disease Huntington Chorea HD Huntington'S Chorea Huntington Chronic Progressive Hereditary Chorea Juvenile Huntington Disease Chronic Progressive Chorea Chronic Progressive Hereditary Chorea Hc - [Huntington Chorea] Hereditary Chorea Progressive Hereditary Chorea
Severe Covid-19
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13902	Berzosertib		99.67%	Phase 2
HY-13735H	Quinacrine acetate		/	Phase 2

Pre-clinical Phase

Bioactive Molecules (94)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114180	RU.521	Inhibitor	99.95%	Unkown
HY-131454	SR-717	Agonist	99.89%	Unkown
HY-133916	G140	Inhibitor	99.17%	Unkown
HY-128583	G150	Inhibitor	99.20%	Unkown
HY-160225	ISD sodium		98.02%	Unkown
HY-150751	ODN TTAGGG		99.87%	Unkown
HY-114182	PF-06928215	Inhibitor	99.68%	Unkown
HY-P1680	Astin C	Inhibitor	99.47%	Unkown
HY-150751C	ODN TTAGGG sodium	Antagonist	93.80%	Unkown
HY-W021040	Fludioxonil		99.94%	Unkown
HY-172208	PROTAC cGAS degrader-1	Degrader	99.07%	Unkown
HY-139056	SU0268	Inhibitor	99.96%	Unkown
HY-160546	cGAS-IN-2	Inhibitor	99.67%	Unkown
HY-P5997	XQ2B	Inhibitor	99.45%	Unkown
HY-149526	cGAS-IN-1	Inhibitor	98.21%	Unkown
HY-123230	Trifloxystrobin	Inhibitor	99.49%	Unkown
HY-164288	TDI-6570	Inhibitor	99.64%	Unkown
HY-114181	IRAK4-IN-4	Inhibitor	99.55%	Unkown
HY-131454A	SR-717 free acid	Agonist	99.36%	Unkown
HY-170362	cGAS-IN-4	Inhibitor	99.28%	Unkown
HY-124700	LYPLAL1-IN-1		99.9%	Unkown
HY-174801	XL-3156	Inhibitor	99.91%	Unkown
HY-116214	Cyprodinil		98.84%	Unkown
HY-158045	PROTAC PARP1 degrader-1	Degrader	99.86%	Unkown
HY-174802	XL-3158	Inhibitor	99.55%	Unkown
HY-N2616	Vomicine	Inhibitor	99.85%	Unkown
HY-141831	STF-1084	Inhibitor	99.92%	Unkown
HY-B1331	Cyromazine		99.79%	Unkown
HY-170362A	(R)-cGAS-IN-4	Control	99.94%	Unkown
HY-171692	G3-YSD		98.37%	Unkown
HY-RS02576	CGAS Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-177338	STING agonist-45	Agonist	99.10%	Unkown
HY-132221	CU-32	Inhibitor	98.8%	Unkown
HY-123230R	Trifloxystrobin (Standard)	Inhibitor	99.15%	Unkown
HY-116214R	Cyprodinil (Standard)		99.04%	Unkown
HY-160225F	Biotin-labeled ISD sodium		/	Unkown
HY-RS02577	Cgas Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W411604	tert-Butyl hex-5-ynoate		/	Unkown
HY-118578	Furalaxyl	Inhibitor	99.3%	Unkown
HY-12464	Butafenacil		98.99%	Unkown
HY-184095	Iptocigistat	Inhibitor	/	Unkown
HY-116214S	Cyprodinil-d5		/	Unkown
HY-116214S1	Cyprodinil-13C6		/	Unkown
HY-123230S	Trifloxystrobin-d6	Inhibitor	/	Unkown
HY-123230S1	Trifloxystrobin-d3		/	Unkown
HY-13902A	Berzosertib hydrochloride		98.77%	Unkown
HY-139678	SC13		/	Unkown
HY-144328	STING agonist-10	Activator	/	Unkown
HY-144329	STING agonist-11	Activator	/	Unkown
HY-147129	cGAS-IN-9	Inhibitor	/	Unkown
HY-150751A	Biotin-labeled ODN TTAGGG sodium		/	Unkown
HY-150751B	FITC-labeled ODN TTAGGG sodium	Antagonist	/	Unkown
HY-158126	G-quadruplex ligand 2	Inhibitor	/	Unkown
HY-159925	QKY-613	Activator	98.24%	Unkown
HY-162459	cGAS-IN-3	Inhibitor	/	Unkown
HY-162944	NA-Ir		/	Unkown
HY-162966	MS7829	Activator	/	Unkown
HY-162967	MS8588	Degrader	/	Unkown
HY-163461	4F-DDC	Inhibitor	/	Unkown
HY-169225	PDIC-NN	Inducer	/	Unkown
HY-169225A	PDIC-NN dimethanesulfonate		/	Unkown
HY-172218	Lenalidomide-hex-5-ynoic acid		/	Unkown
HY-175472	(GalNAc)3-CPT		/	Unkown
HY-176256	endo-S-cGAFMP	Agonist	/	Unkown
HY-178032	PARP1-IN-44		/	Unkown
HY-178431	MT-44		/	Unkown
HY-179147	cGAS-IN-6	Inhibitor	/	Unkown
HY-179624	cGAS-IN-7	Inhibitor	/	Unkown
HY-180211	cGAS-IN-8	Inhibitor	/	Unkown
HY-180555	SN38-(PEG)2-Pom-α	Activator	/	Unkown
HY-181850	Telomeric G4s ligand 2		/	Unkown
HY-182360	Cytisine-platinum(IV) prodrug-1		/	Unkown
HY-182758	Topoisomerase I-IN-21		/	Unkown
HY-182926	Topoisomerase I/II-IN-9	Inhibitor	/	Unkown
HY-183748	XL-20		/	Unkown
HY-N12507	Eupenicisirenin C	Inhibitor	/	Unkown
HY-N15159	Cladophorol A	Inhibitor	/	Unkown
HY-P3041	Chromostatin (bovine)	Inhibitor	/	Unkown
HY-P3864	Pancreastatin (37-52), human	Inhibitor	/	Unkown
HY-RS02575	CGA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS02578	Cgas Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W020788	Benoxacor		99.39%	Unkown
HY-114730	CGA-JK3	Inhibitor	/	Unkown
HY-165620	Etacelasil		/	Unkown
HY-RS17789	Cga Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24257	Cga Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W010319S	2-Amino-4-methoxy-6-methyl-1,3,5-triazine-d3		/	Unkown
HY-W021040S	Fludioxonil-13C3		/	Unkown
HY-W289054S	(S)-Metolachlor metabolite CGA 50720-d3		/	Unkown
HY-W681867	Fluxofenim		98.03%	Unkown
HY-W714168S	(rac)-Metolachlor metabolite CGA 351916-d3		/	Unkown
HY-W714705S	(S)-Metolachlor metabolite CGA 368208-d3 sodium salt		/	Unkown
HY-W722289S	(rac)-Metolachlor metabolite CGA 50267-d3		/	Unkown
HY-W751253	Dofenapyn		/	Unkown

Bioactive MoleculesInhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990181	Anti-Mouse myeloperoxidase/MPO Antibody (6G4)	Inhibitor	95.00%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CGAS	VGNC	VGNC:43047
Rattus norvegicus	CGAS	RGD	RGD:1586939
Bos taurus	CGAS	VGNC	VGNC:31271
Felis catus	CGAS	VGNC	VGNC:60830
Macaca mulatta	CGAS	VGNC	VGNC:71069
Mus musculus	CGAS	MGD	MGI:2442261
Others	CGAS	NCBI