2. Gene
  3. CGAS - cyclic GMP-AMP synthase Gene

CGAS - cyclic GMP-AMP synthase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MB21D1; h-cGAS; C6orf150

Gene ID: 115004 | Gene type: protein coding

About CGAS

Cytogenetic location: 6q13 Genomic coordinates (GRCh38): 6:73,423,711-73,452,297 (from NCBI)

This gene has 4 transcripts (splice variants), 185 orthologues and 9 paralogues.

Summary

Enables several functions, including 2',3'-cyclic GMP-AMP synthase activity; chromatin binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including cellular response to exogenous dsRNA; positive regulation of intracellular signal transduction; and regulation of defense response. Located in several cellular components, including cytosol; nucleus; and site of double-strand break. [provided by Alliance of Genome Resources, Apr 2022]

CGAS Products(3)

mRNA Protein Name
NM_138441.3 NP_612450.2 cyclic GMP-AMP synthase isoform 1
XM_047418159.1 XP_047274115.1 cyclic GMP-AMP synthase isoform X1
NM_001410911.1 NP_001397840.1 cyclic GMP-AMP synthase isoform 2

CGAS Protein Structure

Mab-21

Mab-21: Mab-21 protein (213 - 510)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 522 a.a.
Protein Preferred Names Protein Names

cyclic GMP-AMP synthase

2'3'-cGAMP synthase

Mab-21 domain containing 1

cGAMP synthase

mab-21 domain-containing protein 1

protein MB21D1

Recombinant CGAS Proteins

Cat. No. Product Name Accession Purity
HY-P71597 cGAS Protein, Human (His-SUMO) Q8N884 (G161-F522) ≥95%
HY-P72337 cGAS Protein, Human (His) Q8N884-1 (M1-F522) ≥95%

Related Diseases

Diseases Alias
Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome

Cree Encephalitis

Encephalopathy With Basal Ganglia Calcification

Aicardi-Goutières Syndrome

Ags

Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

Pseudotoxoplasmosis Syndrome

Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

Aicardi-Goutieres Syndrome 1
Covid-19

2019 Novel Coronavirus

2019-Ncov Infection

Covid19

Sars-Cov-2 Infection

Wuhan Coronavirus Infection

Wuhan Seafood Market Pneumonia Virus Infection
Chilblain Lupus 1

Chilblain Lupus

CHBL1

Chilblain Lupus Erythematosus

Chle

Hutchinson Lupus

Chilblain Lupus, Type 1
Sting-Associated Vasculopathy With Onset In Infancy

Savi

Sting-Associated Vasculopathy, Infantile Onset

Sting-Associated Vasculopathy, Infantile-Onset
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Chikungunya

Chikungunya Fever

Arbovirus A Chikungunya Type

Chik

Chikv Infection

Ck

Chikungunya Virus Infection

Chikungunya Haemorrhagic Fever

Chikungunya Viral Disease

Chikungunya Mosquito-Borne Viral Fever
Vasculopathy, Retinal, With Cerebral Leukoencephalopathy And Systemic Manifestations

Crv

Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations

Rvcl

Rvcl-S

Vasculopathy, Retinal, With Cerebral Leukodystrophy

Retinopathy, Vascular, With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena

Retinal Vasculopathy With Cerebral Leukodystrophy

Retinal Vasculopathy And Cerebral Leukoencephalopathy

Hereditary Vascular Retinopathy

Hvr

RVCLS

Cerebroretinal Vasculopathy, Hereditary

Cerebroretinal Vasculopathy

Herns

Vasculopathy, Retinal, With Cerebral Leukodystrophy, Formerly

Hereditary Cerebroretinal Vasculopathy

Hereditary Endotheliopathy, Retinopathy, Nephropathy, Stroke

Hereditary Systemic Angiopathy

Hsa

Retinal Vasculopathy With Cerebral Leukodystrophy With Systemic Manifestations

Adrvcl

Autosomal Dominant Retinal Vasculopathy With Cerebral Leukodystrophy

Hereditary Endotheliopathy With Retinopathy-Nephropathy-Stroke

Vascular Retinopathy With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena
Cutaneous Lupus Erythematosus

Lupus Erythematosus, Cutaneous

Lupus Erythematosus Cutaneous
Huntington Disease

Huntington'S Disease

Huntington Chorea

HD

Huntington'S Chorea

Huntington Chronic Progressive Hereditary Chorea

Juvenile Huntington Disease

Chronic Progressive Chorea

Chronic Progressive Hereditary Chorea

Hc - [Huntington Chorea]

Hereditary Chorea

Progressive Hereditary Chorea
Severe Covid-19
Herpes Simplex

Herpes Simplex Infections

Herpesvirus Hominis Disease

Herpes Simplex Disease

Herpesviral Infection Due To Herpes Simplex

Infections Due To Simplex Virus

Herpes Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (28)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-114180 RU.521 Inhibitor 99.89% Unkown
HY-131454 SR-717 Agonist 99.89% Unkown
HY-128583 G150 Inhibitor 98.61% Unkown
HY-133916 G140 Inhibitor 98.11% Unkown
HY-114182 PF-06928215 Inhibitor 99.69% Unkown
HY-150751 ODN TTAGGG Antagonist 99.87% Unkown
HY-139056 SU0268 Inhibitor 99.84% Unkown
HY-123230 Trifloxystrobin Inhibitor 99.68% Unkown
HY-114181 IRAK4-IN-4 Inhibitor 99.85% Unkown
HY-131454A SR-717 free acid Agonist / Unkown
HY-118578 Furalaxyl Inhibitor / Unkown
HY-123230R Trifloxystrobin (Standard) Inhibitor / Unkown
HY-123230S Trifloxystrobin-d6 Inhibitor / Unkown
HY-12464 Butafenacil / Unkown
HY-144328 STING agonist-10 Activator / Unkown
HY-144329 STING agonist-11 Activator / Unkown
HY-149526 cGAS-IN-1 Inhibitor / Unkown
HY-150751A Biotin-labeled ODN TTAGGG sodium / Unkown
HY-150751B FITC-labeled ODN TTAGGG sodium / Unkown
HY-160546 cGAS-IN-2 Inhibitor / Unkown
HY-162133 MSA-2-Pt Agonist / Unkown
HY-N12507 Eupenicisirenin C Inhibitor / Unkown
HY-RS02575 CGA Human Pre-designed siRNA Set A / Unkown
HY-RS02576 CGAS Human Pre-designed siRNA Set A / Unkown
HY-RS02577 Cgas Mouse Pre-designed siRNA Set A / Unkown
HY-RS02578 Cgas Rat Pre-designed siRNA Set A / Unkown
HY-114730 CGA-JK3 Inhibitor / Unkown
HY-79648S Fmoc-Methylalanine-d3 / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CGAS VGNC VGNC:43047
Rattus norvegicus CGAS RGD RGD:1586939
Bos taurus CGAS VGNC VGNC:31271
Felis catus CGAS VGNC VGNC:60830
Macaca mulatta CGAS VGNC VGNC:71069
Mus musculus CGAS MGD MGI:2442261
Others CGAS NCBI