Adrb2 - adrenergic receptor, beta 2 Gene

Also Known as Badm; Gpcr7; Adrb-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11555

Summary

This intronless gene belongs to the G-protein-coupled receptor superfamily, which includes transmembrane proteins that play a role in signal transduction across biological membranes resulting in a variety of physiological responses. The encoded protein is a beta-2 Adrenergic Receptor which is activated by Catecholamine ligands such as adrenaline and epinephrine. The protein participates in the classical signaling pathway involving G protein, adenylyl cyclase, cAMP (3'-5'-cyclic adenosine monophosphate) and protein kinase A (PKA). In humans, this gene is implicated in susceptibility to nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Apr 2013]

Adrb2 Products (1)

mRNA Protein Name
NM_007420.3 NP_031446.2 beta-2 adrenergic receptor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables adenylate cyclase binding IDA
IDA: Inferred from direct assay
12297500 MGI
enables beta2-adrenergic receptor activity IDA
IDA: Inferred from direct assay
2834198 MGI
enables enzyme binding IPI
IPI: Inferred from physical interaction
19801680 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9235896 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
2834198 MGI
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15724149 MGI
acts upstream of or within bone resorption IMP
IMP: Inferred from mutant phenotype
15724149 MGI
acts upstream of or within brown fat cell differentiation IGI
IGI: Inferred from genetic interaction
12387862 MGI
involved in cellular response to amyloid-beta IGI
IGI: Inferred from genetic interaction
20395454 MGI
acts upstream of or within diet induced thermogenesis IGI
IGI: Inferred from genetic interaction
12161655 MGI
acts upstream of or within heat generation IGI
IGI: Inferred from genetic interaction
12161655 MGI
acts upstream of or within negative regulation of multicellular organism growth IGI
IGI: Inferred from genetic interaction
12387862 MGI
acts upstream of or within negative regulation of smooth muscle contraction IGI
IGI: Inferred from genetic interaction
12925702 MGI
acts upstream of or within norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IGI
IGI: Inferred from genetic interaction
10358009 MGI
acts upstream of or within norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IMP
IMP: Inferred from mutant phenotype
10358009 MGI
acts upstream of or within positive regulation of bone mineralization IMP
IMP: Inferred from mutant phenotype
15724149 MGI
involved in positive regulation of cAMP/PKA signal transduction IGI
IGI: Inferred from genetic interaction
20395454 MGI
involved in positive regulation of cold-induced thermogenesis IGI
IGI: Inferred from genetic interaction
12387862 MGI
involved in positive regulation of mini excitatory postsynaptic potential IGI
IGI: Inferred from genetic interaction
20395454 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15724149 MGI
acts upstream of or within regulation of sodium ion transport IMP
IMP: Inferred from mutant phenotype
15016730 MGI
acts upstream of or within regulation of systemic arterial blood pressure by norepinephrine-epinephrine IMP
IMP: Inferred from mutant phenotype
10358008 MGI
acts upstream of or within response to cold IGI
IGI: Inferred from genetic interaction
12161655 MGI
acts upstream of smooth muscle contraction IGI
IGI: Inferred from genetic interaction
12925702 MGI
acts upstream of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15724149 MGI
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
14625387 MGI
located in membrane IDA
IDA: Inferred from direct assay
2834198 MGI
is active in neuronal dense core vesicle EXP
EXP: Inferred from Experiment
21321602 MGI
is active in neuronal dense core vesicle IDA
IDA: Inferred from direct assay
21321602 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15791602 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

beta-2 adrenergic receptor

  • beta 2-AR

  • beta-2 adrenoceptor

  • beta-2 adrenoreceptor

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14299 Indacaterol Agonist 99.98% Unkown
HY-14299A Indacaterol maleate Agonist 99.82% Unkown
HY-14299D Indacaterol acetate Agonist / Unkown

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13338 Mabuterol Agonist 99.96% Unkown
HY-RS00415 ADRB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16956 Adrb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-14299B (S)-Indacaterol / Unkown
HY-152051S Mabuterol-d9 hydrochloride Agonist / Unkown
HY-RS23399 Adrb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W755295 Mabuterol hydrochloride Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adrb2 NCBI NCBI:154