SLC5A11 - solute carrier family 5 member 11 Gene

Also Known as KST1; RKST1; SGLT6; SMIT2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 115584

About SLC5A11

Cytogenetic location: 16p12.1 Genomic coordinates (GRCh38): 16:24,845,963-24,911,626 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 211 orthologues and 11 paralogues. Biased expression in small intestine (RPKM 3.6), brain (RPKM 1.7) and 2 other tissues.

Summary

Cotransporters, such as SLC5A11, represent a major class of proteins that make use of ion gradients to drive active transport for the cellular accumulation of nutrients, neurotransmitters, osmolytes, and ions Roll et al. (2002) [PubMed 12039040].[supplied by OMIM, Mar 2008]

SLC5A11 Products (21)

mRNA Protein Name
NM_001258411.3 NP_001245340.1 sodium/myo-inositol cotransporter 2 isoform 2
NM_001258412.3 NP_001245341.1 sodium/myo-inositol cotransporter 2 isoform 3
NM_001258413.3 NP_001245342.1 sodium/myo-inositol cotransporter 2 isoform 4
NM_001258414.2 NP_001245343.1 sodium/myo-inositol cotransporter 2 isoform 5
NM_001352235.2 NP_001339164.1 sodium/myo-inositol cotransporter 2 isoform 6
NM_001352236.2 NP_001339165.1 sodium/myo-inositol cotransporter 2 isoform 4
NM_001352237.2 NP_001339166.1 sodium/myo-inositol cotransporter 2 isoform 7
NM_001352238.2 NP_001339167.1 sodium/myo-inositol cotransporter 2 isoform 2
NM_001352242.2 NP_001339171.1 sodium/myo-inositol cotransporter 2 isoform 1
NM_001352245.2 NP_001339174.1 sodium/myo-inositol cotransporter 2 isoform 8
NM_001352246.2 NP_001339175.1 sodium/myo-inositol cotransporter 2 isoform 8
NM_001352247.2 NP_001339176.1 sodium/myo-inositol cotransporter 2 isoform 9
NM_001352248.3 NP_001339177.1 sodium/myo-inositol cotransporter 2 isoform 1
NM_001352249.2 NP_001339178.1 sodium/myo-inositol cotransporter 2 isoform 4
NM_001352250.2 NP_001339179.1 sodium/myo-inositol cotransporter 2 isoform 10
NM_001352259.2 NP_001339188.1 sodium/myo-inositol cotransporter 2 isoform 4
NM_001394076.1 NP_001381005.1 sodium/myo-inositol cotransporter 2 isoform 10
NM_001394077.1 NP_001381006.1 sodium/myo-inositol cotransporter 2 isoform 11
NM_001394078.1 NP_001381007.1 sodium/myo-inositol cotransporter 2 isoform 12
NM_001394079.1 NP_001381008.1 sodium/myo-inositol cotransporter 2 isoform 13
NM_001394080.1 NP_001381009.1 sodium/myo-inositol cotransporter 2 isoform 14

SLC5A11 Protein Structure

SSF

SSF: Sodium:solute symporter family (58 - 487)

  • 0
  • 200
  • 400
  • 600
  • 675 a.a.
Protein Preferred Names Protein Names

sodium/myo-inositol cotransporter 2

  • Na(+)/myo-inositol cotransporter 2

SLC5A11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SLC5A11 Q8WWX8 KPNA3 Homo sapiens O00505
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Systemic Lupus Erythematosus

  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]
Benign Familial Infantile Epilepsy

  • Benign Familial Infantile Seizures

  • Bfie

  • Benign Familial Infantile Convulsion

  • Bfic

  • Bfis

  • Benign Familial Infantile Convulsions

  • Familial Benign Neonatal Epilepsy

  • Watanabe-Vigevano Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13284 SLC5A11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SLC5A11 RGD RGD:621410
Macaca mulatta SLC5A11 VGNC VGNC:77759
Mus musculus SLC5A11 MGD MGI:1919316
Felis catus SLC5A11 VGNC VGNC:65400
Canis familiaris SLC5A11 VGNC VGNC:46444
Bos taurus SLC5A11 VGNC VGNC:34904
Others SLC5A11 NCBI