ZNF653 - zinc finger protein 653 Gene

Also Known as ZIP67; E430039K05Rik

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 115950

Summary

Enables AF-2 domain binding activity; DNA-binding transcription factor binding activity; and transcription corepressor activity. Involved in extracellular negative regulation of signal transduction and negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jun 2026]
Broad expression in testis (RPKM 5.2), brain (RPKM 2.1) and 25 other tissues.

ZNF653 Products (1)

mRNA Protein Name
NM_138783.4 NP_620138.2 zinc finger protein 653

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables AF-2 domain binding IMP
IMP: Inferred from mutant phenotype
12920234 GOA
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
12920234 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
12920234 GOA
Biological Process GO Annotation Evidence References Source
involved in extracellular negative regulation of signal transduction IDA
IDA: Inferred from direct assay
12920234 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12920234 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF653 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZNF653 Q96CK0 TRIM41 Homo sapiens Q8WV44
Y2H Array
32296183
Intra
ZNF653 Q96CK0 TRIM41 Homo sapiens Q8WV44
Y2H Prey Pooling
32296183
Intra
ZNF653 Q96CK0 CEP76 Homo sapiens Q8TAP6
Y2H Array
32296183
Intra
ZNF653 Q96CK0 CEP76 Homo sapiens Q8TAP6
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16163 ZNF652 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16164 ZNF683 Human Pre-designed siRNA Set A Pre-designed Set / Unkown