Akt2 - thymoma viral proto-oncogene 2 Gene

Also Known as PKB; PKBbeta; 2410016A19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11652

About Akt2

Chromosome 7: 27,290,977-27,340,251 forward strand.GRCm39:CM001000.3

This gene has 14 transcripts (splice variants), 237 orthologues, 5 paralogues and is associated with 35 phenotypes. Ubiquitous expression in subcutaneous fat pad adult (RPKM 4.3), mammary gland adult (RPKM 35.7) and 28 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in several processes, including cellular response to Insulin stimulus; intracellular protein transmembrane transport; and positive regulation of transport. Acts upstream of or within with a negative effect on protein localization to nucleus. Acts upstream of or within several processes, including activation of GTPase activity; cellular response to high light intensity; and peripheral nervous system myelin maintenance. Located in cell cortex and ruffle membrane. Is expressed in several structures, including brown fat; central nervous system; genitourinary system; retina; and spleen. Used to study polycystic ovary syndrome and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple); high grade glioma; hypoinsulinemic hypoglycemia with hemihypertrophy; and reproductive organ Cancer (multiple). Orthologous to human Akt2 (Akt serine/threonine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Akt2 Products (4)

mRNA Protein Name
NM_001331109.1 NP_001318038.1 RAC-beta serine/threonine-protein kinase
NM_001331108.1 NP_001318037.1 RAC-beta serine/threonine-protein kinase
NM_001110208.2 NP_001103678.1 RAC-beta serine/threonine-protein kinase
NM_007434.4 NP_031460.1 RAC-beta serine/threonine-protein kinase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12791994 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
21907143 MGI
enables protein serine/threonine kinase activity EXP
EXP: Inferred from Experiment
19372382 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
21148297 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within activation of GTPase activity IGI
IGI: Inferred from genetic interaction
21148297 MGI
acts upstream of or within cellular response to high light intensity IMP
IMP: Inferred from mutant phenotype
17202487 MGI
acts upstream of or within glucose metabolic process IMP
IMP: Inferred from mutant phenotype
17202487 MGI
acts upstream of or within insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
21148297 MGI
acts upstream of or within peripheral nervous system myelin maintenance IMP
IMP: Inferred from mutant phenotype
20448149 MGI
acts upstream of or within positive regulation of D-glucose import IGI
IGI: Inferred from genetic interaction
21907143 MGI
involved in positive regulation of protein targeting to membrane IMP
IMP: Inferred from mutant phenotype
21907143 MGI
acts upstream of or within protein localization to plasma membrane IGI
IGI: Inferred from genetic interaction
21907143 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
21907143 MGI
acts upstream of or within retinal rod cell apoptotic process IMP
IMP: Inferred from mutant phenotype
17202487 MGI
Cellular Component GO Annotation Evidence References Source
located in cell cortex IMP
IMP: Inferred from mutant phenotype
21907143 MGI
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
21907143 MGI
located in ruffle membrane IMP
IMP: Inferred from mutant phenotype
21907143 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Akt2 Protein Structure

PH_PKB

PH_PKB: cd01241 (3 - 110)

STKc_PKB_beta

STKc_PKB_beta: cd05595 (155 - 477)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 481 a.a.
Protein Preferred Names Protein Names

RAC-beta serine/threonine-protein kinase

  • PKB beta

  • RAC-PK-beta

  • protein kinase Akt-2

  • protein kinase B, beta

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15431 Capivasertib Inhibitor 99.96% Unkown
HY-B0960 Sulfabenzamide 99.68% Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99118 Serplulimab Inducer 99.30% Unkown

Clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Phase
HY-N0004 Oridonin Inhibitor 99.89% Phase 4
HY-15727 Afuresertib Inhibitor 99.53% Phase 3
HY-15186A Ipatasertib dihydrochloride Inhibitor 99.27% Phase 3
HY-15186C Ipatasertib tosylate Inhibitor / Phase 3
HY-19719 Miransertib Inhibitor 99.32% Phase 2
HY-108232 MK-2206 Inhibitor 99.72% Phase 2
HY-15965 Uprosertib Inhibitor 99.93% Phase 2
HY-19934 Pifusertib Inhibitor 99.81% Phase 2
HY-10358 MK-2206 dihydrochloride Inhibitor 99.99% Phase 1
HY-10249 GSK-690693 Inhibitor 99.03% Phase 1
HY-100018 BAY1125976 Inhibitor 99.52% Phase 1
HY-16071 AT13148 Inhibitor 99.20% Phase 1
HY-137458A Vevorisertib trihydrochloride Inhibitor 99.60% Phase 1

Pre-clinical Phase

Bioactive Molecules (30)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15186 Ipatasertib Inhibitor 99.88% Yes
HY-10355 AKT inhibitor VIII Inhibitor 98.97% Unkown
HY-10425 Rizavasertib Inhibitor 99.04% Unkown
HY-133120 INY-03-041 Inhibitor 99.74% Unkown
HY-13260 CCT128930 Inhibitor 99.69% Unkown
HY-151504 Engasertib Inhibitor 99.65% Unkown
HY-12059 AT7867 Inhibitor 99.85% Unkown
HY-19934A Pifusertib hydrochloride Inhibitor 99.90% Unkown
HY-19982 AKT-IN-6 Inhibitor 99.08% Unkown
HY-15727A Afuresertib hydrochloride Inhibitor 99.95% Yes
HY-19719A Miransertib hydrochloride Inhibitor 99.74% Yes
HY-50862 Akt1/Akt2-IN-1 Inhibitor 99.30% Unkown
HY-145282 MS170 Inhibitor 98.68% Unkown
HY-12059A AT7867 dihydrochloride Inhibitor 99.73% Unkown
HY-137458 Vevorisertib Inhibitor 98.03% Unkown
HY-133120A INY-03-041 trihydrochloride Inhibitor 99.78% Unkown
HY-132302 Hu7691 Inhibitor 99.91% Unkown
HY-13260A CCT128930 hydrochloride Inhibitor 98.97% Unkown
HY-16666 3CAI Inhibitor 98.32% Unkown
HY-129119 Akt1/Akt2-IN-2 Inhibitor 98.57% Unkown
HY-151613 MS15 Inhibitor / Unkown
HY-126257 AKT-IN-3 Inhibitor 98.12% Unkown
HY-143883 MS143 Degrader 97.8% Unkown
HY-132302A Hu7691 free base Inhibitor / Unkown
HY-145281 MS98 Inhibitor / Unkown
HY-10357 MK-2206 free base Inhibitor / Unkown
HY-138767 AKT-IN-5 Inhibitor / Unkown
HY-143611 AKT-IN-8 Inhibitor / Unkown
HY-15965A Uprosertib hydrochloride Inhibitor / Unkown
HY-16032 Akt1-IN-2 Inhibitor 99.83% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Akt2 NCBI NCBI:208