2. Gene
  3. Mapk8 - mitogen-activated protein kinase 8 Gene

Mapk8 - mitogen-activated protein kinase 8 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as JNK

Gene ID: 116554 | Gene type: protein coding

About Mapk8

Primary_assembly 16: 8,638,924-8,721,981 reverse strand.mRatBN7.2:CM026989.1

This gene has 4 transcripts (splice variants), 291 orthologues, 21 paralogues and is associated with 47 phenotypes. Biased expression in Brain (RPKM 159.1), Muscle (RPKM 92.9) and 9 other tissues.

Summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced Apoptosis. This kinase is also involved in UV radiation induced Apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. [provided by RefSeq, Jul 2012]

Mapk8 Products(1)

mRNA Protein Name
NM_053829.2 NP_446281.2 mitogen-activated protein kinase 8

Mapk8 Protein Structure

STKc_JNK

STKc_JNK: cd07850 (24 - 359)

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  • 427 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase 8

MAP kinase 8

MAPK 8

SAPK gamma

c-Jun N-terminal kinase 1

c-jun NH2-terminal kinase

p54 gamma

stress-activated protein kinase JNK1

Related Agents

Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-148063 DB0614 98.80% Unkown
HY-128448 Carmoisine ≥98.0% Unkown
HY-148061 DB1113 99.28% Unkown
HY-RS08121 MAPK8 Human Pre-designed siRNA Set A / Unkown
HY-RS08122 Mapk8 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08123 Mapk8 Rat Pre-designed siRNA Set A / Unkown
HY-RS08124 MAPK8IP1 Human Pre-designed siRNA Set A / Unkown
HY-RS08125 MAPK8IP2 Human Pre-designed siRNA Set A / Unkown
HY-RS08126 MAPK8IP3 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mapk8 NCBI NCBI:5599