Mapk8 - mitogen-activated protein kinase 8 Gene

Also Known as JNK

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 116554

About Mapk8

Primary_assembly 16: 8,638,924-8,721,981 reverse strand.mRatBN7.2:CM026989.1

This gene has 4 transcripts (splice variants), 291 orthologues, 21 paralogues and is associated with 47 phenotypes. Biased expression in Brain (RPKM 159.1), Muscle (RPKM 92.9) and 9 other tissues.

Summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced Apoptosis. This kinase is also involved in UV radiation induced Apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. [provided by RefSeq, Jul 2012]

Mapk8 Products (1)

mRNA Protein Name
NM_053829.2 NP_446281.2 mitogen-activated protein kinase 8

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables JUN kinase activity IDA
IDA: Inferred from direct assay
11849756 RGD
enables kinesin binding IPI
IPI: Inferred from physical interaction
18932217 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16618812 RGD
Biological Process GO Annotation Evidence References Source
involved in SMAD protein signal transduction IMP
IMP: Inferred from mutant phenotype
27769861 RGD
involved in cellular response to amyloid-beta IEP
IEP: Inferred from expression pattern
12534344 RGD
involved in cellular response to interleukin-1 IEP
IEP: Inferred from expression pattern
9513050 RGD
involved in cellular response to oxygen-glucose deprivation IEP
IEP: Inferred from expression pattern
27769861 RGD
involved in cellular response to oxygen-glucose deprivation IMP
IMP: Inferred from mutant phenotype
27769861 RGD
involved in glial cell apoptotic process IEP
IEP: Inferred from expression pattern
14997384 RGD
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
15309413 RGD
involved in neuron development IEP
IEP: Inferred from expression pattern
17568197 RGD
involved in neuron projection development IMP
IMP: Inferred from mutant phenotype
16618812 RGD
acts upstream of or within neuronal stem cell population maintenance IGI
IGI: Inferred from genetic interaction
24388750 RGD
acts upstream of or within neuronal stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
24388750 RGD
involved in positive regulation of DNA replication IMP
IMP: Inferred from mutant phenotype
9487126 RGD
involved in positive regulation of apoptotic process IEP
IEP: Inferred from expression pattern
16699462 RGD
involved in positive regulation of cardiac muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
11259632 RGD
involved in positive regulation of cell migration IDA
IDA: Inferred from direct assay
12853963 RGD
involved in positive regulation of glial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
14997384 RGD
involved in positive regulation of microtubule polymerization IMP
IMP: Inferred from mutant phenotype
16618812 RGD
involved in positive regulation of neuroblast proliferation IMP
IMP: Inferred from mutant phenotype
24388750 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
12534344 RGD
involved in positive regulation of neuron migration IMP
IMP: Inferred from mutant phenotype
24388750 RGD
involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12011047 RGD
involved in regulation of centrosome cycle IMP
IMP: Inferred from mutant phenotype
24388750 RGD
involved in regulation of dense core granule transport IDA
IDA: Inferred from direct assay
29166604 RGD
involved in regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
24388750 RGD
involved in response to hydrogen peroxide IDA
IDA: Inferred from direct assay
14707549 RGD
involved in response to steroid hormone IEP
IEP: Inferred from expression pattern
14512437 RGD
involved in type B pancreatic cell apoptotic process IMP
IMP: Inferred from mutant phenotype
24475223 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
9714150 RGD
located in dendrite cytoplasm IDA
IDA: Inferred from direct assay
9714150 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
9714150 RGD
located in synapse IDA
IDA: Inferred from direct assay
29166604 RGD
located in vesicle IDA
IDA: Inferred from direct assay
16618812 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mapk8 Protein Structure

STKc_JNK

STKc_JNK: cd07850 (24 - 359)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 427 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase 8

  • MAP kinase 8

  • MAPK 8

  • SAPK gamma

  • c-Jun N-terminal kinase 1

  • c-jun NH2-terminal kinase

  • p54 gamma

  • stress-activated protein kinase JNK1

Mapk8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Mapk8 P49185 Syt4 Rattus norvegicus P50232
Y2H
18046461
Intra
Mapk8 P49185 Syt4 Rattus norvegicus P50232
Pull Down
18046461
Intra
Mapk8 P49185 Gria4 Rattus norvegicus P19493
Anti Bait CoIP
18188153
Intra
Mapk8 P49185 Gria2 Rattus norvegicus P19491-3
Anti Bait CoIP
18188153
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N2593 Isorhapontigenin 99.82% Unkown
HY-128448 Carmoisine 98.66% Unkown
HY-148061 DB1113 99.86% Unkown
HY-148063 DB0614 99.92% Unkown
HY-RS08121 MAPK8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08123 Mapk8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-183319 Anticancer agent 320 / Unkown
HY-RS08122 Mapk8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08124 MAPK8IP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08125 MAPK8IP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08126 MAPK8IP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N20729 Eucommin A Modulator / Unkown
HY-RS22065 Mapk8ip1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28583 Mapk8ip1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mapk8 NCBI NCBI:5599