Mapk1 - mitogen activated protein kinase 1 Gene

Also Known as ERT1; Erk2; ERK-2; p42-MAPK

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 116590

About Mapk1

Primary_assembly 11: 83,957,813-84,023,616 reverse strand.mRatBN7.2:CM026984.1

This gene has 2 transcripts (splice variants), 214 orthologues, 21 paralogues and is associated with 82 phenotypes. Biased expression in Brain (RPKM 291.5), Adrenal (RPKM 15.7) and 9 other tissues.

Summary

Enables several functions, including ATP binding activity; MAP kinase activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in several processes, including ERK1 and ERK2 cascade; decidualization; and positive regulation of macromolecule biosynthetic process. Acts upstream of or within peptidyl-serine phosphorylation. Located in several cellular components, including caveola; dendrite cytoplasm; and perikaryon. Part of protein-containing complex. Is active in postsynaptic density. Used to study coronary artery disease (multiple); gastric ulcer; middle cerebral artery infarction; type 2 diabetes mellitus; and ureteral obstruction. Biomarker of renal fibrosis and urethral obstruction. Human ortholog(s) of this gene implicated in Noonan syndrome 13; adenocarcinoma (multiple); pulmonary hypertension; and renal cell carcinoma. Orthologous to human MAPK1 (mitogen-activated protein kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Mapk1 Products (1)

mRNA Protein Name
NM_053842.2 NP_446294.1 mitogen-activated protein kinase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
15027896 RGD
enables MAP kinase activity IDA
IDA: Inferred from direct assay
7889942 RGD
enables MAP kinase activity IMP
IMP: Inferred from mutant phenotype
16955078 RGD
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
26950759 RGD
enables mitogen-activated protein kinase kinase kinase binding IPI
IPI: Inferred from physical interaction
12049732 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12944431 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
16943189 RGD
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
7768935 RGD
Biological Process GO Annotation Evidence References Source
involved in ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
19524539 RGD
involved in MAPK cascade IMP
IMP: Inferred from mutant phenotype
17310240 RGD
involved in cellular response to cAMP IEP
IEP: Inferred from expression pattern
8223435 RGD
involved in cellular response to epidermal growth factor stimulus IEP
IEP: Inferred from expression pattern
8246947 RGD
involved in cellular response to insulin-like growth factor stimulus IEP
IEP: Inferred from expression pattern
9235900 RGD
involved in cellular response to methionine IEP
IEP: Inferred from expression pattern
22676582 RGD
involved in cellular response to platelet-derived growth factor stimulus IEP
IEP: Inferred from expression pattern
8246947 RGD
involved in cellular response to prostaglandin E stimulus IEP
IEP: Inferred from expression pattern
11875501 RGD
involved in cellular response to toxic substance IDA
IDA: Inferred from direct assay
12487375 RGD
involved in decidualization IDA
IDA: Inferred from direct assay
21248290 RGD
involved in diadenosine tetraphosphate biosynthetic process IMP
IMP: Inferred from mutant phenotype
19524539 RGD
involved in estrous cycle IEP
IEP: Inferred from expression pattern
22521590 RGD
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
12072413 RGD
acts upstream of or within peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
7768935 RGD
involved in peptidyl-serine phosphorylation IMP
IMP: Inferred from mutant phenotype
16955078 RGD
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
19524539 RGD
involved in positive regulation of cardiac muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
26884868 RGD
involved in positive regulation of cell migration IEP
IEP: Inferred from expression pattern
15917991 RGD
involved in positive regulation of cell population proliferation IEP
IEP: Inferred from expression pattern
15583728 RGD
involved in positive regulation of protein import into nucleus IMP
IMP: Inferred from mutant phenotype
19524539 RGD
involved in positive regulation of translation IMP
IMP: Inferred from mutant phenotype
15027896 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
12944431 RGD
involved in protein phosphorylation IMP
IMP: Inferred from mutant phenotype
19524539 RGD
involved in response to alcohol IEP
IEP: Inferred from expression pattern
21790671 RGD
involved in response to cocaine IEP
IEP: Inferred from expression pattern
19457111 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
15893655 RGD
involved in response to estrogen IDA
IDA: Inferred from direct assay
11751611 RGD
involved in response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
11679970 RGD
involved in response to nicotine IGI
IGI: Inferred from genetic interaction
11404397 RGD
involved in response to testosterone IEP
IEP: Inferred from expression pattern
22265242 RGD
involved in response to toxic substance IDA
IDA: Inferred from direct assay
17651772 RGD
involved in sensory perception of pain IMP
IMP: Inferred from mutant phenotype
11356865 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
9714150 RGD
located in caveola IDA
IDA: Inferred from direct assay
24567387 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
24567387 RGD
located in dendrite cytoplasm IDA
IDA: Inferred from direct assay
9714150 RGD
located in nucleoplasm IDA
IDA: Inferred from direct assay
7889942 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
9714150 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
24567387 RGD
is active in postsynaptic density IDA
IDA: Inferred from direct assay
7478291 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
15781236 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mapk1 Protein Structure

STKc_ERK1_2_like

STKc_ERK1_2_like: cd07849 (16 - 350)

  • 0
  • 100
  • 200
  • 300
  • 358 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase 1

  • MAP kinase 1

  • MAP kinase 2

  • MAPK 1

  • MAPK 2

  • extracellular-signal-regulated kinase 2

  • mitogen-activated protein kinase 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (24)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13285 Ki16425 99.30% Unkown
HY-136848 SM1-71 Inhibitor 96.09% Unkown
HY-N2484 Methylnissolin Inhibitor 99.92% Unkown
HY-P2456 MBP MAPK Substrate 99.58% Unkown
HY-N0363 (+)-Columbianetin 99.04% Unkown
HY-113788 PF-719 99.52% Unkown
HY-N0363A (+)-Columbianetin acetate 99.83% Unkown
HY-149921 Antiangiogenic agent 3 Inhibitor / Unkown
HY-152087 DCZ19931 Inhibitor / Unkown
HY-172787 FGFR4-IN-23 Inhibitor / Unkown
HY-184145 AKT1-IN-13 / Unkown
HY-E70844 MAP2K2 Recombinant Human Active Protein Kinase / Unkown
HY-N12726 Halociline Inhibitor / Unkown
HY-N17458 N-Acetyldehydroanonaine Ligand / Unkown
HY-N19654 Oxonantenine / Unkown
HY-N3487 Isodorsmanin A / Unkown
HY-P0141 Akt/SKG Substrate Peptide / Unkown
HY-P0141A Akt/SKG Substrate Peptide TFA / Unkown
HY-RS08092 MAPK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08093 Mapk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08094 Mapk1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08115 Mapk3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N0363AR (+)-Columbianetin acetate (Standard) / Unkown
HY-N0363R (+)-Columbianetin (Standard) / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mapk1 NCBI NCBI:5594