2. Gene
  3. Mapk1 - mitogen activated protein kinase 1 Gene

Mapk1 - mitogen activated protein kinase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as ERT1; Erk2; ERK-2; p42-MAPK

Gene ID: 116590 | Gene type: protein coding

About Mapk1

Primary_assembly 11: 83,957,813-84,023,616 reverse strand.mRatBN7.2:CM026984.1

This gene has 2 transcripts (splice variants), 214 orthologues, 21 paralogues and is associated with 82 phenotypes. Biased expression in Brain (RPKM 291.5), Adrenal (RPKM 15.7) and 9 other tissues.

Summary

Enables several functions, including ATP binding activity; MAP kinase activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in several processes, including ERK1 and ERK2 cascade; decidualization; and positive regulation of macromolecule biosynthetic process. Acts upstream of or within peptidyl-serine phosphorylation. Located in several cellular components, including caveola; dendrite cytoplasm; and perikaryon. Part of protein-containing complex. Is active in postsynaptic density. Used to study coronary artery disease (multiple); gastric ulcer; middle cerebral artery infarction; type 2 diabetes mellitus; and ureteral obstruction. Biomarker of renal fibrosis and urethral obstruction. Human ortholog(s) of this gene implicated in Noonan syndrome 13; adenocarcinoma (multiple); pulmonary hypertension; and renal cell carcinoma. Orthologous to human MAPK1 (mitogen-activated protein kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Mapk1 Products(1)

mRNA Protein Name
NM_053842.2 NP_446294.1 mitogen-activated protein kinase 1

Mapk1 Protein Structure

STKc_ERK1_2_like

STKc_ERK1_2_like: cd07849 (16 - 350)

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  • 358 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase 1

MAP kinase 1

MAP kinase 2

MAPK 1

MAPK 2

extracellular-signal-regulated kinase 2

mitogen-activated protein kinase 2

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-10406 Talmapimod Inhibitor 98.97% Phase 2
Pre-clinical Phase
Bioactive Molecules (15)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13285 Ki16425 Antagonist 98.11% Unkown
HY-136848 SM1-71 Inhibitor 96.00% Unkown
HY-P2456 MBP MAPK Substrate 99.71% Unkown
HY-N2232 N-​Feruloyloctopamine Inhibitor 98.49% Unkown
HY-10406A Talmapimod hydrochloride Inhibitor / Unkown
HY-149921 Antiangiogenic agent 3 / Unkown
HY-152087 DCZ19931 Inhibitor / Unkown
HY-N12726 Halociline Inhibitor / Unkown
HY-N3487 Isodorsmanin A / Unkown
HY-P0141 Akt/SKG Substrate Peptide / Unkown
HY-P0141A Akt/SKG Substrate Peptide TFA / Unkown
HY-P3031 Mitogen-activated protein kinase 1 Activator / Unkown
HY-RS08092 MAPK1 Human Pre-designed siRNA Set A / Unkown
HY-RS08093 Mapk1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08094 Mapk1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mapk1 NCBI NCBI:5594