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Ccr5 - C-C motif chemokine receptor 5 Gene

Also Known as Ckr5; Cmkbr5

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 117029

About Ccr5

Primary_assembly 8: 123,752,325-123,759,260 forward strand.mRatBN7.2:CM026981.1

This gene has 1 transcript (splice variant), 151 orthologues, 24 paralogues and is associated with 98 phenotypes. Biased expression in Spleen (RPKM 251.4), Thymus (RPKM 8.4) and 8 other tissues.

Summary

Enables protein kinase binding activity. Involved in several processes, including nervous system development; positive regulation of cytokine production; and response to bacterium. Located in cell surface and endosome. Used to study Alzheimer's disease; plague; and visual epilepsy. Biomarker of several diseases, including artery disease (multiple); diabetes mellitus (multiple); end stage renal disease; orchitis; and uveitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; West Nile fever; autoimmune disease (multiple); berylliosis; and sarcoidosis (multiple). Orthologous to human CCR5 (C-C motif Chemokine Receptor 5). [provided by Alliance of Genome Resources, Apr 2022]

Ccr5 Products (1)

mRNA	Protein	Name
NM_053960.3	NP_446412.2	C-C chemokine receptor type 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14674010	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	14674010	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to transforming growth factor beta stimulus	IEP IEP: Inferred from expression pattern	23110133	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	23110133	RGD
involved in defense response to bacterium	IEP IEP: Inferred from expression pattern	9670989	RGD
involved in fat cell differentiation	IEP IEP: Inferred from expression pattern	17286602	RGD
involved in forebrain development	IEP IEP: Inferred from expression pattern	16516309	RGD
involved in inflammatory response to antigenic stimulus	IEP IEP: Inferred from expression pattern	14674010	RGD
involved in negative regulation of axon extension	IMP IMP: Inferred from mutant phenotype	16537566	RGD
involved in negative regulation of neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	20940264	RGD
involved in positive regulation of cell killing	IMP IMP: Inferred from mutant phenotype	20940264	RGD
involved in positive regulation of cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	16622027	RGD
involved in positive regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	23999490	RGD
involved in positive regulation of fever generation	IMP IMP: Inferred from mutant phenotype	15066130	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	19559698	RGD
involved in positive regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	16790532	RGD
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	16790532	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	19034668	RGD
involved in positive regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	19559698	RGD
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	16790532	RGD
involved in regulation of cell migration	IMP IMP: Inferred from mutant phenotype	20940264	RGD
involved in response to ionizing radiation	IEP IEP: Inferred from expression pattern	16937495	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	19104678	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	16320322	RGD
located in endosome	IDA IDA: Inferred from direct assay	12004163	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ccr5 Protein Structure

7tmA_CCR5_CCR2

0
100
200
300
354 a.a.

Protein Preferred Names	Protein Names
C-C chemokine receptor type 5	C-C CKR-5 CC-CKR-5 CCR-5 MIP-1 alpha receptor chemokine (C-C motif) receptor 5 chemokine (C-C) receptor 5

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13004	Maraviroc	Antagonist	99.98%	Yes
HY-117621A	PF-04634817 succinate	Antagonist	99.50%	Unkown
HY-117621	PF-04634817	Antagonist	98.87%	Unkown

Clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14882	Cenicriviroc	Antagonist	99.51%	Phase 3
HY-14882A	Cenicriviroc Mesylate	Antagonist	99.94%	Phase 3
HY-17377	Vicriviroc maleate	Antagonist	99.91%	Phase 3
HY-17450A	Aplaviroc hydrochloride	Antagonist	99.94%	Phase 3
HY-17450	Aplaviroc	Antagonist	/	Phase 3
HY-118962	E913	Antagonist	/	Phase 3
HY-P1034	DAPTA	Inhibitor	99.40%	Phase 2
HY-109593	BMS-813160	Antagonist	99.93%	Phase 2
HY-101713	Ilacirnon	Inhibitor	98.05%	Phase 2
HY-14230	INCB9471	Antagonist	/	Phase 2
HY-19974	TAK-220	Antagonist	99.95%	Phase 1

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13406	TAK-779	Antagonist	99.89%	Unkown
HY-P4191A	Met-RANTES (human) acetate	Antagonist	99.39%	Unkown
HY-111069	Nifeviroc	Inhibitor	99.39%	Unkown
HY-119101	AZD-5672	Antagonist	95.74%	Unkown
HY-P4191	Met-RANTES (human)	Antagonist	/	Unkown
HY-100261	CCR5 antagonist 1	Antagonist	/	Unkown
HY-107401	Ancriviroc	Antagonist	/	Unkown
HY-152131	CCR5 antagonist 2	Antagonist	/	Unkown
HY-123902	Ophiobolin C	Inhibitor	/	Unkown
HY-179607	LUF8100	Antagonist	98.64%	Unkown
HY-111321	Fuscin	Inhibitor	/	Unkown
HY-108432	BMS-741672	Antagonist	/	Unkown
HY-152132	CCR5 antagonist 3	Inhibitor	/	Unkown
HY-103406	PNU-177864	Inhibitor	/	Unkown
HY-162512	CB-0821	Inhibitor	/	Unkown
HY-119658	PF-4178903	Antagonist	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991653	HGS004	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ccr5	NCBI	NCBI:1234