THEM4 - thioesterase superfamily member 4 Gene

Also Known as CTMP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 117145

About THEM4

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:151,870,866-151,909,511 (from NCBI)

This gene has 5 transcripts (splice variants), 191 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 4.4), testis (RPKM 3.1) and 25 other tissues.

Summary

Protein kinase B (PKB) is a major downstream target of Receptor Tyrosine Kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas. [provided by RefSeq, Jul 2008]

THEM4 Products (1)

mRNA	Protein	Name
NM_053055.5	NP_444283.2	acyl-coenzyme A thioesterase THEM4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables long-chain fatty acyl-CoA hydrolase activity	IDA IDA: Inferred from direct assay	22871024	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19541650	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in fatty acid metabolic process	IDA IDA: Inferred from direct assay	22871024	GOA
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	19168129	GOA
involved in regulation of mitochondrial membrane permeability involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	19168129	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	19604401	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	19604401	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THEM4 Protein Structure

4HBT

0
100
200
240 a.a.

Protein Preferred Names	Protein Names
acyl-coenzyme A thioesterase THEM4	C-terminal modulator protein

THEM4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	THEM4	Q5T1C6	AKT1	Homo sapiens	P31749	Anti Bait CoIP	19541650
Intra	THEM4	Q5T1C6	AKT1	Homo sapiens	P31749	Anti Tag CoIP	19541650
Intra	THEM4	Q5T1C6	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	THEM4	Q5T1C6	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	THEM4	Q5T1C6	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	THEM4	Q5T1C6	PECAM1	Homo sapiens	P16284	Validated Y2H	32814053
Intra	THEM4	Q5T1C6	PECAM1	Homo sapiens	P16284	Y2H Array	32814053
Intra	THEM4	Q5T1C6	PECAM1	Homo sapiens	P16284	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

THEM4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89994	CTMP Antibody (YA9338)	WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA	human

Related Diseases

Diseases	Alias
Erythrocytosis, Familial, 7	ECYT7 Erythrocytosis 7 Familial Erythrocytosis 7 Erythrocytosis, Alpha-Globin Type Polycythemia, Alpha-Globin Type Alpha-Globin Type Erythrocytosis Alpha-Globin Type Polycythemia
Wolf-Hirschhorn Syndrome	Pitt-Rogers-Danks Syndrome WHS Chromosome 4p16.3 Deletion Syndrome Wittwer Syndrome 4p- Syndrome Pitt Syndrome 4p Deletion Syndrome Distal Deletion 4p Distal Monosomy 4p Telomeric Deletion 4p Prds 4p Syndrome Chromosome 4p Syndrome Microcephaly, Iugr, Hypertelorism, Ptosis, Iris Coloboma, Hooked Nose, External Ear Dysplasia, Psychomotor Retardation Wolf Syndrome Chromosome 4p Deletion Syndrome Chromosome 4p Monosomy Del Syndrome Monosomy 4p Partial Monosomy 4p Chromosome 4 Short Arm Deletion

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14485	THEM4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	THEM4	VGNC	VGNC:78406
Felis catus	THEM4	VGNC	VGNC:66159
Rattus norvegicus	THEM4	RGD	RGD:1304723
Mus musculus	THEM4	MGD	MGI:1923028
Canis familiaris	THEM4	VGNC	VGNC:47341
Bos taurus	THEM4	VGNC	VGNC:35833
Others	THEM4	NCBI