2. Gene
  3. MRGPRX2 - MAS related GPR family member X2 Gene

MRGPRX2 - MAS related GPR family member X2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MGRG3; MRGX2

Gene ID: 117194 | Gene type: protein coding

About MRGPRX2

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:19,054,455-19,060,717 (from NCBI)

This gene has 1 transcript (splice variant), 435 orthologues and 10 paralogues. Low expression observed in reference dataset.

Summary

Enables G protein-coupled receptor activity and neuropeptide binding activity. Involved in mast cell degranulation and positive regulation of cytokinesis. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

MRGPRX2 Products(2)

mRNA Protein Name
NM_001303615.2 NP_001290544.1 mas-related G-protein coupled receptor member X2
NM_054030.4 NP_473371.1 mas-related G-protein coupled receptor member X2

MRGPRX2 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (47 - 279)

  • 0
  • 100
  • 200
  • 300
  • 330 a.a.
Protein Preferred Names Protein Names

mas-related G-protein coupled receptor member X2

G protein-coupled receptor MRGX2

Related Diseases

Diseases Alias
Chronic Spontaneous Urticaria

Chronic Idiopathic Urticaria
Ceftazidime Allergy

Fortaz Allergy

Tazicef Allergy
Mastocytosis, Cutaneous

Urticaria Pigmentosa

Cutaneous Mastocytosis

Diffuse Cutaneous Mastocytosis

Maculopapular Cutaneous Mastocytosis

Mastocytosis, Diffuse Cutaneous

MASTC

Mastocytosis, Maculopapular Cutaneous

Mastocytosis, Systemic, Somatic

Mastocytoma

Dcm

Diffuse Cutaneous Maculopapulous Mastocytosis

Up/Mpcm

Cm

Mastocytosis, Systemic

MASTSYS

Mast Cell Disease

Mast-Cell Disease

Mast Cell Leukemia

Mastocytosis, Indolent

Mastocytosis With Associated Hematologic Disorder

Mast Cell Neoplasm

Benign Mastocytoma
Rocuronium Allergy

Esmeron Allergy

Zemuron Allergy
Acute Anterolateral Myocardial Infarction

Acute Myocardial Infarction Of Anterolateral Wall
Mastocytosis

Mast Cell Disease

Mast Cell Hyperplasia

Urticaria Pigmentosa

Malignant Mastocytoma

Malignant Mast Cell Tumours

Malignant Mastocytosis
Chronic Inducible Urticaria
Urticaria

Nettle Rash

Hives

Wheal

Urticaria Nos
Chlorhexidine Allergy
Vibratory Urticaria

Vibratory Angioedema

Dermodistortive Urticaria

VBU

Ddu

Angioedema, Vibratory
Physical Urticaria

Symptomatic Dermographism
Beta-Lactam Allergy
Dermatographia

Dermatographic Urticaria

Dermographism

Symptomatic Dermographism

Urticaria Factitia

Factitious Urticaria

Dermatographism
Cholinergic Urticaria
Corticosteroid Allergy
Drug Allergy

Allergy Drug

Drug Allergies
Cephalosporin Allergy
Chronic Urticaria

Urticaria Chronic

Chronic Spontaneous Urticaria

Chronic Ordinary Urticaria
Penicillin Allergy

Allergy To Penicillin
Indolent Systemic Mastocytosis

Ism
Distal Muscular Dystrophy With Anterior Tibial Onset

Dmat
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (16)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-145191 MrgprX2 antagonist-1 99.93% Unkown
HY-146220 MrgprX2 antagonist-8 Antagonist 97.03% Unkown
HY-118069 (R)-ZINC-3573 Agonist 99.81% Unkown
HY-P3419 PAMP-12 (unmodified) 99.30% Unkown
HY-115682 (S)-ZINC-3573 99.89% Unkown
HY-145192 MrgprX2 antagonist-2 99.20% Unkown
HY-156907 ZINC49534341 Antagonist 99.13% Unkown
HY-145194 MrgprX2 antagonist-4 99.85% Unkown
HY-145892 MrgprX2 antagonist-6 Antagonist / Unkown
HY-145893 MrgprX2 antagonist-7 Antagonist / Unkown
HY-145193 MrgprX2 antagonist-3 99.73% Unkown
HY-145195 MrgprX2 antagonist-5 / Unkown
HY-P3419A PAMP-12 (unmodified) (TFA) Agonist / Unkown
HY-RS08651 MRGPRX2 Human Pre-designed siRNA Set A / Unkown
HY-145193A (R)-MrgprX2 antagonist-3 Antagonist / Unkown
HY-160540 MRGPRX2 modulator-1 Modulator / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MRGPRX2 RGD RGD:738048
Others MRGPRX2 NCBI