MRGPRX2 - MAS related GPR family member X2 Gene

Also Known as MGRG3; MRGX2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 117194

About MRGPRX2

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:19,054,455-19,060,717 (from NCBI)

This gene has 1 transcript (splice variant), 435 orthologues and 10 paralogues. Low expression observed in reference dataset.

Summary

Enables G protein-coupled receptor activity and neuropeptide binding activity. Involved in mast cell degranulation and positive regulation of cytokinesis. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

MRGPRX2 Products (2)

mRNA Protein Name
NM_001303615.2 NP_001290544.1 mas-related G-protein coupled receptor member X2
NM_054030.4 NP_473371.1 mas-related G-protein coupled receptor member X2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled receptor activity IDA
IDA: Inferred from direct assay
12915402 GOA
enables neuropeptide binding IPI
IPI: Inferred from physical interaction
12915402 GOA
Biological Process GO Annotation Evidence References Source
involved in mast cell activation IDA
IDA: Inferred from direct assay
25517090 GOA
involved in mast cell degranulation IDA
IDA: Inferred from direct assay
22069323 GOA
involved in positive regulation of cytokinesis IMP
IMP: Inferred from mutant phenotype
22888021 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MRGPRX2 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (47 - 279)

  • 0
  • 100
  • 200
  • 300
  • 330 a.a.
Protein Preferred Names Protein Names

mas-related G-protein coupled receptor member X2

  • G protein-coupled receptor MRGX2

Related Diseases

Diseases Alias
Chronic Spontaneous Urticaria

  • Chronic Idiopathic Urticaria
Ceftazidime Allergy

  • Fortaz Allergy

  • Tazicef Allergy
Mastocytosis, Cutaneous

  • Urticaria Pigmentosa

  • Cutaneous Mastocytosis

  • Diffuse Cutaneous Mastocytosis

  • Maculopapular Cutaneous Mastocytosis

  • Mastocytosis, Diffuse Cutaneous

  • MASTC

  • Mastocytosis, Maculopapular Cutaneous

  • Mastocytosis, Systemic, Somatic

  • Mastocytoma

  • Dcm

  • Diffuse Cutaneous Maculopapulous Mastocytosis

  • Up/Mpcm

  • Cm

  • Mastocytosis, Systemic

  • MASTSYS

  • Mast Cell Disease

  • Mast-Cell Disease

  • Mast Cell Leukemia

  • Mastocytosis, Indolent

  • Mastocytosis With Associated Hematologic Disorder

  • Mast Cell Neoplasm

  • Benign Mastocytoma
Rocuronium Allergy

  • Esmeron Allergy

  • Zemuron Allergy
Acute Anterolateral Myocardial Infarction

  • Acute Myocardial Infarction Of Anterolateral Wall
Mastocytosis

  • Mast Cell Disease

  • Mast Cell Hyperplasia

  • Urticaria Pigmentosa

  • Malignant Mastocytoma

  • Malignant Mast Cell Tumours

  • Malignant Mastocytosis
Chronic Inducible Urticaria
Urticaria

  • Nettle Rash

  • Hives

  • Wheal

  • Urticaria Nos
Chlorhexidine Allergy
Vibratory Urticaria

  • Vibratory Angioedema

  • Dermodistortive Urticaria

  • VBU

  • Ddu

  • Angioedema, Vibratory
Physical Urticaria

  • Symptomatic Dermographism
Beta-Lactam Allergy
Dermatographia

  • Dermatographic Urticaria

  • Dermographism

  • Symptomatic Dermographism

  • Urticaria Factitia

  • Factitious Urticaria

  • Dermatographism
Cholinergic Urticaria
Corticosteroid Allergy
Drug Allergy

  • Allergy Drug

  • Drug Allergies
Cephalosporin Allergy
Chronic Urticaria

  • Urticaria Chronic

  • Chronic Spontaneous Urticaria

  • Chronic Ordinary Urticaria
Penicillin Allergy

  • Allergy To Penicillin
Indolent Systemic Mastocytosis

  • Ism
Distal Muscular Dystrophy With Anterior Tibial Onset

  • Dmat
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (31)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-145191 MrgprX2 antagonist-1 99.80% Unkown
HY-P3419 PAMP-12 (unmodified) 99.40% Unkown
HY-146220 MrgprX2 antagonist-8 Antagonist 97.00% Unkown
HY-145192 MrgprX2 antagonist-2 99.24% Unkown
HY-145193 MrgprX2 antagonist-3 99.77% Unkown
HY-118069 (R)-ZINC-3573 Agonist 99.83% Unkown
HY-156907 ZINC49534341 Antagonist 99.40% Unkown
HY-N0735 Phellodendrine chloride 99.68% Unkown
HY-145195 MrgprX2 antagonist-5 99.46% Unkown
HY-139690 CCG258747 98.96% Unkown
HY-B1158 Imidazolidinyl urea 99.99% Unkown
HY-160540 MRGPRX2 modulator-1 Modulator 99.03% Unkown
HY-145194 MrgprX2 antagonist-4 99.53% Unkown
HY-178793 MrgprX2 antagonist-9 Antagonist 99.92% Unkown
HY-173003 EP-3945 Agonist 99.17% Unkown
HY-158990 GE1111 95.73% Unkown
HY-N0427 Phellodendrine 99.60% Unkown
HY-115682 (S)-ZINC-3573 99.89% Unkown
HY-185402 MrgprX2 antagonist-10 Antagonist 98.98% Unkown
HY-185405 MrgprX2 antagonist-11 Antagonist 99.32% Unkown
HY-164298 MRGPRX2 modulator-3 Modulator / Unkown
HY-176767 MrgprX2-IN-1 Antagonist / Unkown
HY-176768 MrgprX2-IN-2 Antagonist / Unkown
HY-181891 XAT-13 Inhibitor / Unkown
HY-184281 XAT-14 Inhibitor 98.50% Unkown
HY-185727 MrgprX2 antagonist-12 Antagonist / Unkown
HY-RS08651 MRGPRX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-122967 Isosalvianolic acid C Activator / Unkown
HY-145193A (R)-MrgprX2 antagonist-3 Antagonist / Unkown
HY-RS16850 Mrgprx2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23291 Mrgprx2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MRGPRX2 RGD RGD:738048
Others MRGPRX2 NCBI