Aqp3 - aquaporin 3 Gene

Also Known as AQP-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11828

Summary

Predicted to enable channel activity; identical protein binding activity; and urea transmembrane transporter activity. Involved in glycerol transport and water transport. Acts upstream of or within cellular response to oxygen-glucose deprivation; renal water absorption; and urea transport. Located in basolateral plasma membrane and cell-cell junction. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; lateral plate mesoderm; and thymus. Used to study nephrogenic diabetes insipidus. Orthologous to human AQP3 (Aquaporin 3 (Gill blood group)). [provided by Alliance of Genome Resources, Apr 2022]

Aqp3 Products (1)

mRNA Protein Name
NM_016689.2 NP_057898.2 aquaporin-3

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
11382807 MGI
involved in glycerol transmembrane transport IDA
IDA: Inferred from direct assay
17429015 MGI
acts upstream of or within renal water absorption IGI
IGI: Inferred from genetic interaction
11035042 MGI
acts upstream of or within renal water absorption IMP
IMP: Inferred from mutant phenotype
10795927 MGI
acts upstream of or within response to ischemia IDA
IDA: Inferred from direct assay
24462679 MGI
acts upstream of or within urea transport IMP
IMP: Inferred from mutant phenotype
16525162 MGI
involved in water transport IDA
IDA: Inferred from direct assay
17429015 MGI
acts upstream of or within water transport IMP
IMP: Inferred from mutant phenotype
11382807 MGI
Cellular Component GO Annotation Evidence References Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
10322639 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
12042359 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
12042359 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aquaporin-3

  • AQP-3

  • aquaglyceroporin-3

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0557 Bisacodyl Inhibitor 99.71% Yes

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-126073 DFP00173 99.46% Unkown
HY-126074 Z433927330 98.20% Unkown
HY-RS00875 AQP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-157979 AQP3-IN-1 Inhibitor / Unkown
HY-RS17446 Aqp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23902 Aqp3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aqp3 NCBI NCBI:360