Bmp6 - bone morphogenetic protein 6 Gene

Also Known as Vgr1; D13Wsu115e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12161

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Mice lacking this gene exhibit delayed ossification of the sternum, iron overload, and reduced fertility in females. [provided by RefSeq, Jul 2016]

Bmp6 Products (1)

mRNA Protein Name
NM_007556.4 NP_031582.1 bone morphogenetic protein 6 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12897139 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within BMP signaling pathway IDA
IDA: Inferred from direct assay
14623234 MGI
involved in cellular response to iron ion IMP
IMP: Inferred from mutant phenotype
19252488 MGI
acts upstream of or within endochondral ossification IMP
IMP: Inferred from mutant phenotype
9664685 MGI
involved in eye development IGI
IGI: Inferred from genetic interaction
16154126 MGI
involved in inflammatory response IEP
IEP: Inferred from expression pattern
12151307 MGI
acts upstream of or within intracellular iron ion homeostasis IMP
IMP: Inferred from mutant phenotype
21703414 MGI
involved in intracellular iron ion homeostasis IMP
IMP: Inferred from mutant phenotype
19252488 MGI
involved in kidney development IGI
IGI: Inferred from genetic interaction
16154126 MGI
acts upstream of or within male genitalia development IGI
IGI: Inferred from genetic interaction
9664685 MGI
involved in multicellular organismal-level iron ion homeostasis IMP
IMP: Inferred from mutant phenotype
19252488 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
19252488 MGI
acts upstream of or within neuron differentiation IMP
IMP: Inferred from mutant phenotype
14623245 MGI
acts upstream of or within osteoblast differentiation IGI
IGI: Inferred from genetic interaction
16109715 MGI
involved in positive regulation of SMAD protein signal transduction IMP
IMP: Inferred from mutant phenotype
19252488 MGI
involved in positive regulation of endothelial cell differentiation IDA
IDA: Inferred from direct assay
20406889 MGI
involved in positive regulation of endothelial cell proliferation IDA
IDA: Inferred from direct assay
20406889 MGI
involved in positive regulation of lipopolysaccharide-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
19252488 MGI
acts upstream of or within positive regulation of neuron differentiation IDA
IDA: Inferred from direct assay
9786991 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
19252488 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bone morphogenetic protein 6

  • VG-1-related protein

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991637 Exerenibart Inhibitor 98.00% Phase 2

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-16712 LDN-214117 Inhibitor 99.54% Unkown
HY-173149 CDD-2789 Inhibitor / Unkown
HY-118970 LG190155 / Unkown
HY-RS01541 BMP6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17946 Bmp6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24417 Bmp6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991881 KY1070 / Unkown
HY-P990974 Bezeotermin alfa / Unkown
HY-P991880 Anti-BMP6 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bmp6 NCBI NCBI:654