C1qa - complement component 1, q subcomponent, alpha polypeptide Gene

Also Known as C1q; Adic

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12259

Summary

Involved in several processes, including complement-mediated synapse pruning; microglial cell activation; and nervous system development. Acts upstream of or within complement activation, classical pathway. Located in postsynapse. Is expressed in brain; foot; genitourinary system; and pancreas. Used to study epilepsy and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in glomerulonephritis. Orthologous to human C1QA (complement C1q A chain). [provided by Alliance of Genome Resources, Apr 2022]

C1qa Products (1)

mRNA Protein Name
NM_007572.2 NP_031598.2 complement C1q subcomponent subunit A precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22682250 MGI
Biological Process GO Annotation Evidence References Source
involved in astrocyte activation IGI
IGI: Inferred from genetic interaction
15269255 MGI
acts upstream of or within complement activation, classical pathway IMP
IMP: Inferred from mutant phenotype
11901193 MGI
involved in complement-mediated synapse pruning IMP
IMP: Inferred from mutant phenotype
18083105 MGI
involved in microglial cell activation IGI
IGI: Inferred from genetic interaction
15269255 MGI
involved in neuron remodeling IMP
IMP: Inferred from mutant phenotype
18083105 MGI
involved in synapse organization IGI
IGI: Inferred from genetic interaction
27033548 MGI
involved in synapse pruning IGI
IGI: Inferred from genetic interaction
27033548 MGI
involved in vertebrate eye-specific patterning IMP
IMP: Inferred from mutant phenotype
18083105 MGI
Cellular Component GO Annotation Evidence References Source
is active in extrinsic component of postsynaptic membrane IDA
IDA: Inferred from direct assay
23946404 MGI
is active in extrinsic component of presynaptic membrane IDA
IDA: Inferred from direct assay
23946404 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
23946404 MGI
located in postsynapse IGI
IGI: Inferred from genetic interaction
27033548 MGI
located in synapse IDA
IDA: Inferred from direct assay
18083105 MGI
located in synapse IGI
IGI: Inferred from genetic interaction
18083105 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

complement C1q subcomponent subunit A

  • adiponectin c

Recombinant C1qa Proteins

Cat. No. Product Name Accession Purity
HY-P71718 C1QA Protein, Mouse (P.pastoris, His) P98086 (E23-A245) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P72108 C1QA Protein, Mouse (His-SUMO) P98086 (E23-A245) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01718 C1QA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18747 C1qa Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25234 C1qa Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens C1qa NCBI NCBI:712