PSMB11 - proteasome subunit beta 11 Gene

Also Known as BETA5T

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 122706

About PSMB11

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:23,042,212-23,044,060 (from NCBI)

This gene has 1 transcript (splice variant), 228 orthologues and 18 paralogues.

Summary

Proteasomes generate peptides that are presented by major histocompatibility complex (MHC) I molecules to Other cells of the immune system. Proteolysis is conducted by 20S proteasomes, complexes of 28 subunits arranged as a cylinder in 4 heteroheptameric rings: alpha-1 to -7, beta-1 to -7, beta-1 to -7, and alpha-1 to -7. The catalytic subunits are beta-1 (PSMB6; MIM 600307), beta-2 (PSMB7; MIM 604030), and beta-5 (PSMB5; MIM 600306). Three additional subunits, beta-1i (PSMB9; MIM 177045), beta-2i (PSMB10; MIM 176847), and beta-5i (PSMB8; MIM 177046), are induced by gamma-interferon (IFNG; MIM 147570) and are preferentially incorporated into proteasomes to make immunoproteasomes. PSMB11, or beta-5t, is a catalytic subunit expressed exclusively in cortical thymic epithelial cells (Murata et al., 2007 [PubMed 17540904]).[supplied by OMIM, Mar 2008]

PSMB11 Products (1)

mRNA	Protein	Name
NM_001099780.2	NP_001093250.1	proteasome subunit beta type-11

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables peptidase activity	IDA IDA: Inferred from direct assay	17540904	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within proteolysis	IDA IDA: Inferred from direct assay	17540904	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMB11 Protein Structure

Proteasome

0
100
200
300 a.a.

Protein Preferred Names	Protein Names
proteasome subunit beta type-11	proteasome (prosome, macropain) subunit, beta type, 11

PSMB11 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PSMB11	A5LHX3	ATG5	Homo sapiens	Q9H1Y0	Validated Y2H	32296183
Intra	PSMB11	A5LHX3	TLX3	Homo sapiens	O43711	Validated Y2H	32296183
Intra	PSMB11	A5LHX3	HGS	Homo sapiens	O14964	Validated Y2H	32296183
Intra	PSMB11	A5LHX3	PITX1	Homo sapiens	P78337	Validated Y2H	32296183
Intra	PSMB11	A5LHX3	PROP1	Homo sapiens	O75360	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

PSMB11 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89731	PSMB11 Antibody (YA9075)	WB, ICC/IF, IF-Tissue, IP, ELISA	human

Related Diseases

Diseases	Alias
Encapsulated Thymoma
Thymic Dysplasia
Disseminated Chorioretinitis
Thymoma	Primary Thymic Epithelial Neoplasm Primary Thymic Epithelial Tumor Thymus Neoplasms
Predominantly Cortical Thymoma	Lymphocyte-Predominant Thymoma Thymoma, Organoid Thymoma, Type B1
T-Cell Immunodeficiency With Thymic Aplasia	Nezelof Syndrome T-Lymphocyte Deficiency TIDTA Immune Defect Due To Absence Of Thymus Thymic Aplasia Nezelof'S Syndrome Thymic Dysplasia With Normal Immunoglobulins Thymic Aplasia Syndrome T-Lymphocyte Immunodeficiency
Thymic Carcinoma	Malignant Thymoma Thymoma, Malignant
Thymus Gland Disease	Disease Of Thymus Gland
Thymus Cancer	Thymic Neoplasm Thymic Tumor Thymus Neoplasm Thymus Neoplasms Malignant Neoplasm Of Thymus Neoplasm Of Thymus Thymic Neoplasms Thymoma, Familial Thymic Carcinoma Thymoma, Type C Cancer Of Thymus Malignant Tumour Of Thymus Primary Malignant Neoplasm Of Thymus Thymic Glandular Cancer Thymus Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11301	PSMB11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PSMB11	MGD	MGI:1921152
Felis catus	PSMB11	VGNC	VGNC:64413
Rattus norvegicus	PSMB11	RGD	RGD:1308773
Canis familiaris	PSMB11	VGNC	VGNC:45094
Bos taurus	PSMB11	VGNC	VGNC:33445
Others	PSMB11	NCBI