Car2 - carbonic anhydrase 2 Gene

Also Known as Ca2; CAII; Car-2; Ltw-5; Lvtw-5

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12349

About Car2

Chromosome 3: 14,951,333-14,965,830 forward strand.GRCm39:CM000996.3

This gene has 3 transcripts (splice variants), 285 orthologues, 15 paralogues and is associated with 19 phenotypes. Biased expression in liver E14 (RPKM 556.3), liver E14.5 (RPKM 538.2) and 14 other tissues.

Summary

Enables carbonate dehydratase activity. Involved in positive regulation of dipeptide transmembrane transport and regulation of intracellular pH. Acts upstream of or within several processes, including carbon dioxide transport; positive regulation of GABAergic synaptic transmission; and positive regulation of cellular pH reduction. Located in cytosol and myelin sheath. Is expressed in several structures, including alimentary system; brain; heart; metanephros; and sensory organ. Used to study autosomal recessive osteopetrosis 3. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 3 and osteopetrosis. Orthologous to human CA2 (Carbonic Anhydrase 2). [provided by Alliance of Genome Resources, Apr 2022]

Car2 Products (2)

mRNA Protein Name
NM_009801.5 NP_033931.4 carbonic anhydrase 2
NM_001357334.1 NP_001344263.1 carbonic anhydrase 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables carbonate dehydratase activity IDA
IDA: Inferred from direct assay
14660577 MGI
enables carbonate dehydratase activity IMP
IMP: Inferred from mutant phenotype
23881097 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15218065 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within carbon dioxide transport IMP
IMP: Inferred from mutant phenotype
16217040 MGI
acts upstream of or within morphogenesis of an epithelium IMP
IMP: Inferred from mutant phenotype
16217040 MGI
acts upstream of or within neuron cellular homeostasis IMP
IMP: Inferred from mutant phenotype
23881097 MGI
acts upstream of or within positive regulation of cellular pH reduction IMP
IMP: Inferred from mutant phenotype
23881097 MGI
involved in positive regulation of dipeptide transmembrane transport IMP
IMP: Inferred from mutant phenotype
20150244 MGI
acts upstream of or within positive regulation of synaptic transmission, GABAergic IGI
IGI: Inferred from genetic interaction
23881097 MGI
acts upstream of or within regulation of chloride transport IMP
IMP: Inferred from mutant phenotype
23881097 MGI
involved in regulation of intracellular pH IMP
IMP: Inferred from mutant phenotype
20150244 MGI
acts upstream of or within secretion IMP
IMP: Inferred from mutant phenotype
16217040 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
15385584 MGI
located in myelin sheath IDA
IDA: Inferred from direct assay
14600151 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Car2 Protein Structure

alpha_CA

alpha_CA: cl00012 (0 - 258)

  • 0
  • 100
  • 200
  • 260 a.a.
Protein Preferred Names Protein Names

carbonic anhydrase 2

  • carbonate dehydratase II

  • carbonic anhydrase II

Recombinant Car2 Proteins

Cat. No. Product Name Accession Purity
HY-P72861 Carbonic Anhydrase 2 Protein, Mouse (HEK293, His) AAH55291 (S2-K260) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-183912 PY-4Car2 Inhibitor / Unkown
HY-D2620 CAR-2 Inducer / Unkown
HY-RS01768 CA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01909 Car2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01910 Car2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01934 CARS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22414 Cars2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28937 Cars2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown