Casp6 - caspase 6 Gene

Also Known as Mch2; CASP-6

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12368

About Casp6

Chromosome 3: 129,695,074-129,707,752 forward strand.GRCm39:CM000996.3

This gene has 4 transcripts (splice variants), 268 orthologues, 11 paralogues and is associated with 7 phenotypes. Ubiquitous expression in duodenum adult (RPKM 36.2), small intestine adult (RPKM 29.7) and 27 other tissues.

Summary

This gene encodes a member of the cysteine proteases that plays important roles in regulating Apoptosis and neurodegeneration. The encoded protein is involved in the transmission of pain and axonal degeneration. Genetic deletion of this gene in mice results in the delay of axon pruning and protects from axon degeneration. [provided by RefSeq, Apr 2015]

Casp6 Products (1)

mRNA	Protein	Name
NM_009811.4	NP_033941.3	caspase-6 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	25231987	MGI
enables endopeptidase activity	IDA IDA: Inferred from direct assay	22555455	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16439475	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Casp6 Protein Structure

CASc

0
100
200
276 a.a.

Protein Preferred Names	Protein Names
caspase-6	apoptotic protease Mch-2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125194	NWL-117	Inhibitor	/	Unkown
HY-RS01959	CASP6 Human Pre-designed siRNA Set A		/	Unkown
HY-RS01960	Casp6 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS01961	CASP6 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Casp6	NCBI	NCBI:839