NOXO1 - NADPH oxidase organizer 1 Gene

Also Known as SNX28; P41NOX; P41NOXA; P41NOXB; P41NOXC; SH3PXD5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 124056

About NOXO1

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,978,917-1,981,469 (from NCBI)

This gene has 7 transcripts (splice variants), 283 orthologues and 3 paralogues. Broad expression in colon (RPKM 2.7), appendix (RPKM 0.9) and 14 other tissues.

Summary

This gene encodes an NADPH Oxidase (NOX) organizer, which positively regulates NOX1 and NOX3. The protein contains a PX domain and two SH3 domains. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]

NOXO1 Products (4)

mRNA Protein Name
NM_001267721.2 NP_001254650.1 NADPH oxidase organizer 1 isoform d
NM_144603.4 NP_653204.1 NADPH oxidase organizer 1 isoform a
NM_172167.3 NP_751907.1 NADPH oxidase organizer 1 isoform b
NM_172168.3 NP_751908.1 NADPH oxidase organizer 1 isoform c

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
16636067 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16460309 GOA
Biological Process GO Annotation Evidence References Source
involved in extracellular matrix disassembly IMP
IMP: Inferred from mutant phenotype
19755710 GOA
Cellular Component GO Annotation Evidence References Source
part of NADPH oxidase complex IDA
IDA: Inferred from direct assay
16636067 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOXO1 Protein Structure

PX

PX: PX domain (21 - 125)

SH3_1

SH3_1: SH3 domain (247 - 288)

  • 0
  • 100
  • 200
  • 300
  • 376 a.a.
Protein Preferred Names Protein Names

NADPH oxidase organizer 1

  • NADPH oxidase regulatory protein

NOXO1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NOXO1 Q8NFA2 NOXA1 Homo sapiens Q86UR1
Pull Down
17126813
Intra
NOXO1 Q8NFA2 NOXA1 Homo sapiens Q86UR1
Anti Bait CoIP
35031518
Intra
NOXO1 Q8NFA2 CYBA Homo sapiens P13498
Pull Down
16460309
Intra
NOXO1 Q8NFA2 CYBA Homo sapiens P13498
Anti Bait CoIP
35031518
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lung Mucoepidermoid Carcinoma

  • Mucoepidermoid Carcinoma Of Lung
Phagocyte Bactericidal Dysfunction

  • Phagocytic Dysfunction
Granulomatous Disease, Chronic, Autosomal Recessive, 1

  • Chronic Granulomatous Disease Due To Deficiency Of Ncf-1

  • CGD1

  • Ncf1 Deficiency

  • Soluble Oxidase Component Ii Deficiency

  • Soc2 Deficiency

  • P47-Phox Deficiency

  • Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type I

  • Deficiency Of Neutrophil Cytosol Factor 1

  • Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 1

  • Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type I

  • Cgd, Autosomal Recessive Cytochrome B-Positive, Type I

  • Granulomatous Disease, Chronic, Due To Ncf1 Deficiency

  • Neutrophil Cytosol Factor 1 Deficiency

  • Chronic Granulomatous Disease 1, Autosomal Recessive

  • Autosomal Recessive Chronic Granulomatous Disease 1

  • Cdg1

  • Deficiency Of Ncf1

  • Deficiency Of P47-Phox

  • Deficiency Of Soc2

  • Deficiency Of Soluble Oxidase Component Ii

  • Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type I

  • Chronic Granulomatous Disease Due To Ncf1 Deficiency
Chronic Granulomatous Disease

  • Cgd

  • Granulomatous Disease, Chronic

  • Autosomal Recessive Chronic Granulomatous Disease

  • X-Linked Chronic Granulomatous Disease

  • Bridges-Good Syndrome

  • Congenital Dysphagocytosis

  • Quie Syndrome

  • Chronic Septic Granulomatosis

  • Chronic Granulomatous Disorder

  • Granulomatous Disease Chronic

  • Granulomatous Disease, Chronic, X-Linked
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09466 NOXO1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NOXO1 RGD RGD:1307802
Bos taurus NOXO1 VGNC VGNC:32187
Canis familiaris NOXO1 VGNC VGNC:43907
Macaca mulatta NOXO1 VGNC VGNC:75215
Felis catus NOXO1 VGNC VGNC:82349
Mus musculus NOXO1 MGD MGI:1919143
Others NOXO1 NCBI