SLC43A2 - solute carrier family 43 member 2 Gene

Also Known as LAT4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 124935

About SLC43A2

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:1,569,254-1,630,088 (from NCBI)

This gene has 12 transcripts (splice variants), 1 gene allele, 283 orthologues and 1 paralogue. Broad expression in placenta (RPKM 24.5), kidney (RPKM 14.0) and 16 other tissues.

Summary

This gene encodes a member of the L-amino acid transporter-3 or SLC43 family of transporters. The encoded protein mediates sodium-, chloride-, and pH-independent transport of L-isomers of neutral Amino acids, including leucine, phenylalanine, valine and methionine. This protein may contribute to the transfer of Amino acids across the placental membrane to the fetus. [provided by RefSeq, Mar 2016]

SLC43A2 Products (5)

mRNA	Protein	Name
NM_001284498.2	NP_001271427.1	large neutral amino acids transporter small subunit 4 isoform 1
NM_001284499.1	NP_001271428.1	large neutral amino acids transporter small subunit 4 isoform 3
NM_001321364.2	NP_001308293.1	large neutral amino acids transporter small subunit 4 isoform 1
NM_001321365.2	NP_001308294.1	large neutral amino acids transporter small subunit 4 isoform 1
NM_152346.3	NP_689559.1	large neutral amino acids transporter small subunit 4 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables L-isoleucine transmembrane transporter activity	IDA IDA: Inferred from direct assay	15659399	GOA
enables L-leucine transmembrane transporter activity	IDA IDA: Inferred from direct assay	15659399	GOA
enables L-methionine transmembrane transporter activity	IDA IDA: Inferred from direct assay	15659399	GOA
enables L-phenylalanine transmembrane transporter activity	IDA IDA: Inferred from direct assay	30379325	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in L-leucine transport	IDA IDA: Inferred from direct assay	15659399	GOA
involved in isoleucine transport	IDA IDA: Inferred from direct assay	15659399	GOA
involved in methionine transport	IDA IDA: Inferred from direct assay	15659399	GOA
acts upstream of or within negative regulation of L-leucine import across plasma membrane	IDA IDA: Inferred from direct assay	26305885	GOA
acts upstream of or within negative regulation of amino acid transport	IDA IDA: Inferred from direct assay	26305885	GOA
involved in phenylalanine transport	IDA IDA: Inferred from direct assay	30379325	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC43A2 Protein Structure

MFS_1

0
100
200
300
400
500
569 a.a.

Protein Preferred Names	Protein Names
large neutral amino acids transporter small subunit 4	L-type amino acid transporter 4

SLC43A2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLC43A2	Q8N370	KRT35	Homo sapiens	Q92764	Y2H Array	32296183
Intra	SLC43A2	Q8N370	KRT35	Homo sapiens	Q92764	Y2H Prey Pooling	32296183
Intra	SLC43A2	Q8N370	KRT35	Homo sapiens	Q92764	Validated Y2H	32296183
Intra	SLC43A2	Q8N370	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	SLC43A2	Q8N370	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	SLC43A2	Q8N370	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	SLC43A2	Q8N370	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	SLC43A2	Q8N370	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	SLC43A2	Q8N370	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	SLC43A2	Q8N370	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	SLC43A2	Q8N370	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13249	SLC43A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19844	Slc43a2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26342	Slc43a2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLC43A2	RGD	RGD:1305819
Mus musculus	SLC43A2	MGD	MGI:2442746
Macaca mulatta	SLC43A2	VGNC	VGNC:77554
Bos taurus	SLC43A2	VGNC	VGNC:34875
Felis catus	SLC43A2	VGNC	VGNC:65370
Canis familiaris	SLC43A2	VGNC	VGNC:46416
Others	SLC43A2	NCBI