AFMID - arylformamidase Gene

Also Known as KF; FKF; KFA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 125061

About AFMID

This gene has 15 transcripts (splice variants), 189 orthologues and 5 paralogues. Broad expression in kidney (RPKM 25.1), liver (RPKM 16.9) and 25 other tissues.

Summary

Predicted to enable hydrolase activity. Predicted to be involved in tryptophan catabolic process to kynurenine. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

AFMID Products (11)

mRNA Protein Name
NM_001010982.5 NP_001010982.2 kynurenine formamidase isoform 2
NM_001145526.3 NP_001138998.1 kynurenine formamidase isoform 1
NM_001391999.1 NP_001378928.1 kynurenine formamidase isoform 3
NM_001392000.1 NP_001378929.1 kynurenine formamidase isoform 4
NM_001392001.1 NP_001378930.1 kynurenine formamidase isoform 5
NM_001392002.1 NP_001378931.1 kynurenine formamidase isoform 6
NM_001392003.1 NP_001378932.1 kynurenine formamidase isoform 7
NM_001392004.1 NP_001378933.1 kynurenine formamidase isoform 8
NM_001392005.1 NP_001378934.1 kynurenine formamidase isoform 9
NM_001392006.1 NP_001378935.1 kynurenine formamidase isoform 10
NM_001392007.1 NP_001378936.1 kynurenine formamidase isoform 11

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AFMID Protein Structure

Abhydrolase_3

Abhydrolase_3: alpha/beta hydrolase fold (92 - 279)

  • 0
  • 100
  • 200
  • 303 a.a.
Protein Preferred Names Protein Names

kynurenine formamidase

  • KFase

AFMID Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
AFMID Q63HM1 MEI4 Homo sapiens A8MW99
Y2H Prey Pooling
32296183
Intra
AFMID Q63HM1 MEI4 Homo sapiens A8MW99
Y2H Array
32296183
Intra
AFMID Q63HM1 MED18 Homo sapiens Q9BUE0
Y2H Prey Pooling
32296183
Intra
AFMID Q63HM1 MED18 Homo sapiens Q9BUE0
Validated Y2H
32296183
Intra
AFMID Q63HM1 MED18 Homo sapiens Q9BUE0
Y2H Array
32296183
Intra
AFMID Q63HM1 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
Intra
AFMID Q63HM1 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra
AFMID Q63HM1 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypertryptophanemia

  • HYPTRP

  • Hypertryptophanemia, Familial

  • Familial Hypertryptophanemia
Glaucomatocyclitic Crisis

  • Posner-Schlossman Syndrome

  • Terrien-Viel Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00434 AFMID Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20852 Afmid Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27367 Afmid Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus AFMID RGD RGD:1591143
Mus musculus AFMID MGD MGI:2448704
Bos taurus AFMID VGNC VGNC:25716
Felis catus AFMID VGNC VGNC:97342
Macaca mulatta AFMID VGNC VGNC:81345
Others AFMID NCBI