HMGB4 - high mobility group box 4 Gene

Also Known as dJ1007G16.5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 127540

About HMGB4

Cytogenetic location: 1p35.1 Genomic coordinates (GRCh38): 1:33,860,475-33,864,791 (from NCBI)

This gene has 5 transcripts (splice variants), 255 orthologues and 20 paralogues. Restricted expression toward testis (RPKM 70.9).

Summary

Predicted to enable DNA binding activity, bending. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

HMGB4 Products (3)

mRNA Protein Name
NM_001352984.2 NP_001339913.1 high mobility group protein B4 isoform 2
NM_001379301.1 NP_001366230.1 high mobility group protein B4 isoform 1
NM_145205.6 NP_660206.2 high mobility group protein B4 isoform 1

HMGB4 Protein Structure

HMG_box_2

HMG_box_2: HMG-box domain (8 - 78)

HMG_box

HMG_box: HMG (high mobility group) box (93 - 161)

  • 0
  • 100
  • 186 a.a.
Protein Preferred Names Protein Names

high mobility group protein B4

  • HMG2 like

HMGB4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HMGB4 Q8WW32 KRTAP12-4 Homo sapiens P60329
Y2H Prey Pooling
25416956
Intra
HMGB4 Q8WW32 CEP70 Homo sapiens Q8NHQ1
Validated Y2H
25416956
Intra
HMGB4 Q8WW32 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
Intra
HMGB4 Q8WW32 CEP70 Homo sapiens Q8NHQ1
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06235 HMGB4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HMGB4 RGD RGD:1596426
Bos taurus HMGB4 VGNC VGNC:29876
Canis familiaris HMGB4 VGNC VGNC:41711
Felis catus HMGB4 VGNC VGNC:82378
Macaca mulatta HMGB4 VGNC VGNC:73437
Mus musculus HMGB4 MGD MGI:1916567
Others HMGB4 NCBI