2. Gene
  3. Ccr5 - chemokine (C-C motif) receptor 5 Gene

Ccr5 - chemokine (C-C motif) receptor 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as AM4-7; CD195; Cmkbr5

Gene ID: 12774 | Gene type: protein coding

About Ccr5

Chromosome 9: 123,921,580-123,947,736 forward strand.GRCm39:CM001002.3

This gene has 6 transcripts (splice variants), 151 orthologues, 25 paralogues and is associated with 50 phenotypes. Ubiquitous expression in subcutaneous fat pad adult (RPKM 2.2), mammary gland adult (RPKM 2.1) and 27 other tissues.

Summary

Enables C-C chemokine binding activity and C-C Chemokine Receptor activity. Involved in negative regulation of macrophage apoptotic process. Acts upstream of or within defense response. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; liver and biliary system; and reproductive system. Used to study Coronavirus infectious disease. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; West Nile fever; autoimmune disease (multiple); berylliosis; and sarcoidosis (multiple). Orthologous to human CCR5 (C-C motif Chemokine Receptor 5). [provided by Alliance of Genome Resources, Apr 2022]

Ccr5 Products(1)

mRNA Protein Name
NM_009917.5 NP_034047.2 C-C chemokine receptor type 5

Ccr5 Protein Structure

7tmA_CCR5_CCR2

7tmA_CCR5_CCR2: cd15184 (32 - 59)

7tmA_CCR5_CCR2

7tmA_CCR5_CCR2: cd15184 (32 - 309)

7tmA_CCR5_CCR2

7tmA_CCR5_CCR2: cd15184 (66 - 91)

7tmA_CCR5_CCR2

7tmA_CCR5_CCR2: cd15184 (102 - 132)

7tmA_CCR5_CCR2

7tmA_CCR5_CCR2: cd15184 (144 - 166)

7tmA_CCR5_CCR2

7tmA_CCR5_CCR2: cd15184 (192 - 221)

7tmA_CCR5_CCR2

7tmA_CCR5_CCR2: cd15184 (229 - 259)

7tmA_CCR5_CCR2

7tmA_CCR5_CCR2: cd15184 (277 - 302)

  • 0
  • 100
  • 200
  • 300
  • 354 a.a.
Protein Preferred Names Protein Names

C-C chemokine receptor type 5

C-C CKR-5

CC-CKR-5

CCR-5

MIP-1 alpha receptor

chemokine (C-C) receptor 5

Recombinant Ccr5 Proteins

Cat. No. Product Name Accession Purity
HY-P700540 CCR5 Protein, Mouse (P. pastoris, His) P51682 (Q263-L354) ≥95%

Related Agents

Approval
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13004 Maraviroc Antagonist 99.71% Yes
HY-117621 PF-04634817 Antagonist 98.87% Unkown
HY-117621A PF-04634817 succinate Antagonist ≥99.0% Unkown
Clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-14882 Cenicriviroc Antagonist 99.01% Phase 3
HY-14882A Cenicriviroc Mesylate Antagonist 99.04% Phase 3
HY-17377 Vicriviroc maleate Antagonist 99.91% Phase 3
HY-17450A Aplaviroc hydrochloride Antagonist 99.76% Phase 3
HY-17450 Aplaviroc Antagonist / Phase 3
HY-109593 BMS-813160 Antagonist 99.93% Phase 2
HY-P1034 DAPTA Inhibitor 99.85% Phase 2
Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13406 TAK-779 Antagonist 99.73% Unkown
HY-19974 TAK-220 Antagonist 99.95% Unkown
HY-101713 Ilacirnon Inhibitor 99.87% Unkown
HY-119101 AZD-5672 Antagonist ≥95.0% Yes
HY-111069 Nifeviroc Inhibitor 98.17% Unkown
HY-152131 CCR5 antagonist 2 Antagonist / Unkown
HY-111321 Fuscin Inhibitor / Unkown
HY-152132 CCR5 antagonist 3 Inhibitor / Unkown
HY-100261 CCR5 antagonist 1 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ccr5 NCBI NCBI:1234