NUP35 - nucleoporin 35 Gene

Also Known as MP44; NP44; MP-44; NUP53

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 129401

About NUP35

Cytogenetic location: 2q32.1 Genomic coordinates (GRCh38): 2:183,117,514-183,161,680 (from NCBI)

This gene has 10 transcripts (splice variants) and 215 orthologues. Ubiquitous expression in testis (RPKM 6.9), adrenal (RPKM 3.5) and 25 other tissues.

Summary

This gene encodes a member of the nucleoporin family. The encoded protein contains two membrane binding regions, is localized to the nuclear rim, and is part of the nuclear pore complex. All molecules entering or leaving the nucleus either diffuse through or are actively transported by the nuclear pore complex. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 7 and 10. [provided by RefSeq, Dec 2013]

NUP35 Products (3)

mRNA Protein Name
NM_001287584.2 NP_001274513.1 nucleoporin NUP35 isoform b
NM_001287585.2 NP_001274514.1 nucleoporin NUP35 isoform c
NM_138285.5 NP_612142.2 nucleoporin NUP35 isoform a

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Cellular Component GO Annotation Evidence References Source
located in nuclear envelope IDA
IDA: Inferred from direct assay
24315095 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUP35 Protein Structure

Nup35_RRM

Nup35_RRM: Nup53/35/40-type RNA recognition motif (169 - 250)

  • 0
  • 100
  • 200
  • 300
  • 326 a.a.
Protein Preferred Names Protein Names

nucleoporin NUP35

  • mitotic phosphoprotein 44

NUP35 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NUP35 Q8NFH5 KCTD9 Homo sapiens Q7L273
Validated Y2H
25416956
Intra
NUP35 Q8NFH5 KCTD9 Homo sapiens Q7L273
Anti Tag CoIP
28514442
Intra
NUP35 Q8NFH5 KCTD9 Homo sapiens Q7L273
Y2H Array
25416956
Intra
NUP35 Q8NFH5 KCTD9 Homo sapiens Q7L273
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Seminal Vesicle Tumor

  • Tumor Of Seminal Vesicle

  • Seminal Vesicle Neoplasm

  • Seminal Vesicle Tumour

  • Tumour Of Seminal Vesicle
Achalasia-Addisonianism-Alacrima Syndrome

  • Allgrove Syndrome

  • Triple-A Syndrome

  • Achalasia-Addisonianism-Alacrimia Syndrome

  • Alacrima-Achalasia-Adrenal Insufficiency Neurologic Disorder

  • Triple A Syndrome

  • Aaa Syndrome

  • AAAS

  • Glucocorticoid Deficiency With Achalasia

  • Glucocorticoid Deficiency And Achalasia

  • Addisonian-Achalasia Syndrome

  • Hypoadrenalism With Achalasia

  • Alacrima-Achalasia-Addisonianism

  • Aaa

  • Acth-Resistant Adrenal Insufficiency, Achalasia And Alacrima

  • Achalasia Addisonianism Alacrimia Syndrome

  • Achalasia Alacrima Syndrome

  • Addisonian Achalasia Syndrome

  • Achalasia-Addisonian Syndrome

  • Achalasia-Alacrima Syndrome

  • 2a Syndrome

  • 3a Syndrome

  • 4a Syndrome

  • Adrenal Insufficiency-Achalasia-Alacrima Syndrome

  • Double A Syndrome

  • Quaternary A Syndrome

  • Acth-Resistant Adrenal Insufficiency With Achalasia And Alacrima

  • Allgrove'S Syndrome

  • Adrenal Gland Hypofunction

  • Adrenal Cortical Hypofunction
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09693 NUP35 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NUP35 MGD MGI:1916732
Bos taurus NUP35 VGNC VGNC:32359
Macaca mulatta NUP35 VGNC VGNC:75486
Canis familiaris NUP35 VGNC VGNC:44053
Felis catus NUP35 VGNC VGNC:63924
Rattus norvegicus NUP35 RGD RGD:1303069
Others NUP35 NCBI