Dao - D-amino acid oxidase Gene

Also Known as DAAO; Dao1; DAMOX; Dao-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13142

Summary

Enables D-amino-acid oxidase activity and FAD binding activity. Involved in D-alanine catabolic process. Acts upstream of or within leucine metabolic process. Predicted to be located in cytosol and peroxisomal membrane. Predicted to be active in cytoplasm. Predicted to colocalize with mitochondrial outer membrane. Is expressed in metanephros; renal cortex; ureter; and urinary system. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human DAO (D-amino acid oxidase). [provided by Alliance of Genome Resources, Apr 2022]

Dao Products (3)

mRNA Protein Name
NM_001286396.1 NP_001273325.1 D-amino-acid oxidase isoform 1
NM_001286397.1 NP_001273326.1 D-amino-acid oxidase isoform 2
NM_010018.3 NP_034148.2 D-amino-acid oxidase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables D-amino-acid dehydrogenase activity IMP
IMP: Inferred from mutant phenotype
1686595 MGI
enables D-amino-acid oxidase activity IDA
IDA: Inferred from direct assay
20567862 MGI
enables FAD binding IDA
IDA: Inferred from direct assay
20603179 MGI
Biological Process GO Annotation Evidence References Source
involved in D-alanine catabolic process IDA
IDA: Inferred from direct assay
20603179 MGI
acts upstream of or within L-leucine metabolic process IMP
IMP: Inferred from mutant phenotype
15026304 MGI
involved in digestion IMP
IMP: Inferred from mutant phenotype
6147398 MGI
involved in dopamine biosynthetic process IMP
IMP: Inferred from mutant phenotype
17042912 MGI
involved in killing by host of symbiont cells IDA
IDA: Inferred from direct assay
27670111 MGI
involved in neutrophil-mediated killing of gram-negative bacterium IDA
IDA: Inferred from direct assay
25425233 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
27670111 MGI
located in peroxisomal matrix IDA
IDA: Inferred from direct assay
1686595 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

D-amino-acid oxidase

  • D-amino acid oxidase 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-P2758 Diamine oxidase / Phase 4
HY-B1041 Aminoguanidine hydrochloride ≥98.0% Phase 1

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-117292 DAO-IN-2 Inhibitor 99.95% Unkown
HY-W037417 DAO-IN-1 Inhibitor 97.46% Unkown
HY-15913 DAOS 99.88% Unkown
HY-W027382 SEP-227900 99.44% Unkown
HY-RS03523 DAO Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-173255 DAO-dBET1 Degrader / Unkown
HY-RS00771 AOC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17364 Aoc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18733 Dao Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23818 Aoc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25220 Dao Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W026426 4,5,6,7-Tetrahydro-1,2-benzoxazole-3-carboxylic acid Inhibitor 98.06% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dao NCBI NCBI:1610