JMY - junction mediating and regulatory protein, p53 cofactor Gene

Also Known as WHAMM2; WHDC1L3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 133746

About JMY

Cytogenetic location: 5q14.1 Genomic coordinates (GRCh38): 5:79,236,131-79,327,211 (from NCBI)

This gene has 2 transcripts (splice variants), 250 orthologues and 2 paralogues. Ubiquitous expression in endometrium (RPKM 8.1), thyroid (RPKM 7.3) and 25 other tissues.

Summary

Predicted to enable Arp2/3 complex binding activity and transcription coactivator activity. Predicted to be involved in several processes, including actin nucleation; intrinsic apoptotic signaling pathway by p53 class mediator; and regulation of transcription, DNA-templated. Located in cell leading edge. [provided by Alliance of Genome Resources, Apr 2022]

JMY Products (1)

mRNA	Protein	Name
NM_152405.5	NP_689618.4	junction-mediating and #NAME? protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables microtubule binding	IDA IDA: Inferred from direct assay	30420355	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10518217	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to starvation	IMP IMP: Inferred from mutant phenotype	30420355	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in autophagosome membrane	IDA IDA: Inferred from direct assay	30420355	GOA
located in cell leading edge	IDA IDA: Inferred from direct assay	19287377	GOA
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	30420355	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
junction-mediating and -regulatory protein	WAS protein homology region 2 domain containing 1-like 3

JMY Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	JMY	Q8N9B5	MDM2	Homo sapiens	Q00987	Anti Bait CoIP	17170761

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Wiskott-Aldrich Syndrome	WAS Eczema-Thrombocytopenia-Immunodeficiency Syndrome Immunodeficiency 2 Aldrich Syndrome Imd2 Wiskott-Aldrich Syndrome 1 Was1 Wiskott Syndrome Wiskott Aldrich Syndrome Eczema Thrombocytopenia Immunodeficiency Syndrome Imd 2
Phacolytic Glaucoma
Hemoglobin H Disease	HBH Hemoglobin H Disease, Nondeletional Hemoglobin H Disease, Deletional Alpha-Thalassemia Intermedia Haemoglobin H Disease Alpha-Thalassemia, Hemoglobin H Type Hemoglobin H Disease, Deletional And Nondeletional Alpha Thalassemia, Haemoglobin H Type Alpha Thalassemia, Hemoglobin H Type Haemoglobin H Disease, Deletional Hbh Disease Alpha-Thalassemia Hemoglobin H Type Hemoglobin H Disease Deletional Hemoglobin H Disease Non-Deletional Alpha-Thalassemia Alpha - /- - Or Mutational Forms Of Alpha-Thalassaemia Alpha Thalassaemia Intermedia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07042	JMY Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	JMY	VGNC	VGNC:42191
Bos taurus	JMY	VGNC	VGNC:30378
Felis catus	JMY	VGNC	VGNC:63009
Rattus norvegicus	JMY	RGD	RGD:1585601
Macaca mulatta	JMY	VGNC	VGNC:84397
Mus musculus	JMY	MGD	MGI:1913096
Others	JMY	NCBI