Dll3 - delta like canonical Notch ligand 3 Gene

Also Known as pu; pudgy

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13389

Summary

Predicted to enable Notch binding activity. Involved in skeletal system development. Acts upstream of or within anterior/posterior pattern specification; negative regulation of neurogenesis; and paraxial mesoderm development. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including blastocyst; central nervous system; future brain; paraxial mesenchyme; and sensory organ. Used to study spondylocostal dysostosis. Human ortholog(s) of this gene implicated in dysostosis and spondylocostal dysostosis. Orthologous to human DLL3 (delta like canonical Notch ligand 3). [provided by Alliance of Genome Resources, Apr 2022]

Dll3 Products (1)

mRNA Protein Name
NM_007866.2 NP_031892.2 delta-like protein 3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16000382 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within compartment pattern specification IMP
IMP: Inferred from mutant phenotype
12001066 MGI
acts upstream of or within negative regulation of neurogenesis IDA
IDA: Inferred from direct assay
9272948 MGI
acts upstream of or within paraxial mesoderm development IMP
IMP: Inferred from mutant phenotype
15170697 MGI
involved in skeletal system development IMP
IMP: Inferred from mutant phenotype
11923214 MGI
acts upstream of or within somitogenesis IDA
IDA: Inferred from direct assay
9272948 MGI
acts upstream of or within somitogenesis IMP
IMP: Inferred from mutant phenotype
15170697 MGI
acts upstream of or within tissue development IDA
IDA: Inferred from direct assay
9272948 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
34635817 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

delta-like protein 3

  • M-Delta-3

  • delta-like 3

  • delta3

  • drosophila Delta homolog 3

Recombinant Dll3 Proteins

Cat. No. Product Name Accession Purity
HY-P77916 Delta-like protein 3/DLL3 Protein, Mouse (HEK293, His) O88516-1 (A25-R488) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99575 Tarlatamab Inhibitor 99.77% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-132257 Rovalpituzumab tesirine Inhibitor 97.47% Phase 3
Inhibitory Antibodies (6)
Cat. No. Product Name Effect
Purity Phase
HY-P99043 Rovalpituzumab Inhibitor 99.84% Phase 3
HY-P990932 Obrixtamig Inhibitor 99.9% Phase 3
HY-P991731 Alveltamig 99.00% Phase 3
HY-P990920 Gocatamig Inhibitor ≥99.0% Phase 2
HY-P991016 Peluntamig 99.9% Phase 2
HY-P990981 Clesitamig 99.78% Phase 1

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W1126504 ETN029 Ligand 99.91% Unkown
HY-164729 FZ-AD005 97.27% Unkown
HY-159072 Mal-Val-Ala-PAB-N(SO2Me)-Exatecan 98.84% Unkown
HY-RS03809 DLL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16720 Dll3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23156 Dll3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990104 Anti-DLL3 Antibody (anti-DLL3 arm derived from AMG-757) Inhibitor 99.39% Unkown
HY-P990896 FZ-A038 99.15% Unkown
HY-P992148 Zocilurtatug Inhibitor 99.50% Unkown
HY-P991173 AMG-119 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dll3 NCBI NCBI:10683