Zocilurtatug pelitecan
Based on 1 Customer Validation
Zocilurtatug pelitecan (ZL-1310) is a blood-brain barrier-penetrating antibody-drug conjugate targeting DLL3. It consists of the antibody component Zocilurtatug (HY-P992148) and the toxin-linker molecule DL-01 (HY-155870). Zocilurtatug pelitecan induces cell cycle arrest and apoptosis in tumor cells, and inhibits the growth of established human tumors in xenograft models. It can be used in research on extensive-stage small cell lung cancer (SCLC) and neuroendocrine tumors.
For research use only. We do not sell to patients.
- Purity : 97.89%
- CAS No.: 3058592-88-1
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Storage:Shipping with dry ice
-80°C, protect from light
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All Topoisomerase Isoforms
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Biological Activity
Description
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- Flow cytometric DNA-content cell-cycle staining
- Annexin V plus membrane-impermeant dye apoptosis staining
- BrdU Incorporation Assay
- Patient-Derived Xenograft (PDX)
- Apoptosis Solutions
- Protocol for Cell Cycle
- Splenic/Portal-Vein Liver Metastasis Xenograft
- Subcutaneous Cell-Line-Derived Xenograft
- Orthotopic Cell-Line Xenograft
- Intraperitoneal/Peritoneal Dissemination Xenograft
Chemical Information
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CAS No. 3058592-88-1
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Appearance Liquid
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Color Colorless to light yellow
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SMILES
[Zocilurtatug pelitecan]
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Synonyms
ZL-1310
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Shipping
Shipping with dry ice.
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Storage
-80°C, protect from light
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Zocilurtatug pelitecan Related Classifications
HY-188059 Related Classifications
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Keywords
- Zocilurtatug pelitecan
- 3058592-88-1
- ZL-1310
- ZL1310
- ZL 1310
- Antibody-Drug Conjugates (ADCs)
- Notch
- Apoptosis
- Topoisomerase
- Antibody-Drug Conjugates
- ADC
- topoisomerase I inhibitor
- blood-brain barrier
- xenograft models
- DLL3
- DLL3-positive solid tumors
- tumor cells
- small cell lung cancer
- apoptosis
- cell cycle arrest
- Inhibitor
- inhibitor
- inhibit