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Art. -Nr.: HY-188059

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Zocilurtatug pelitecan

Name: Zocilurtatug pelitecan
Brand: MedChemExpress
SKU: HY-188059
Price: 960.00 USD
Availability: PreOrder

(Synonyms: ZL-1310)

Zocilurtatug pelitecan (ZL-1310) is a blood-brain barrier-penetrating antibody-drug conjugate targeting DLL3. It consists of the antibody component Zocilurtatug (HY-P992148) and the toxin-linker molecule DL-01 (HY-155870). Zocilurtatug pelitecan induces cell cycle arrest and apoptosis in tumor cells, and inhibits the growth of established human tumors in xenograft models. It can be used in research on extensive-stage small cell lung cancer (SCLC) and neuroendocrine tumors.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 3058592-88-1

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Zocilurtatug pelitecan Chemical Structure

CAS. Nr.: 3058592-88-1

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

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In Vitro

Zocilurtatug pelitecan (ZL-1310) binds specifically to DLL3 across species but not other Delta family members, and induces internalization, cell cycle arrest, and apoptosis in DLL3-expressing tumor cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ZL-1310 (administered intravenously) exhibits dose-dependent inhibition of tumor growth in CDX and PDX mouse models of DLL3-positive small cell lung cancer, with significant intratumoral accumulation of the cytotoxic payload; additionally, it shows stable pharmacokinetic profiles and acceptable tolerability in GLP toxicology studies conducted in rats and non-human primates^[1]^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 3058592-88-1
SMILES

[Zocilurtatug pelitecan]
Synonyms

ZL-1310
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Lin, L. N., et al. (2024). 241P Development and characterization of a novel DLL3-targeting antibody drug conjugate (ADC) for the treatment of solid tumors. ESMo Open, 9.

[2]. Dowlati, A., et al. (2026). A randomized, open-label, phase 3 study of ZL-1310, a DLL3 antibody-drug conjugate (ADC), compared to investigator’s choice therapy in participants with relapsed small cell lung cancer (DLLEVATE).

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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Zocilurtatug pelitecan

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