NUDCD2 - NudC domain containing 2 Gene

Also Known as NudCL2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 134492

About NUDCD2

This gene has 4 transcripts (splice variants), 199 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 16.1), prostate (RPKM 14.4) and 25 other tissues.

Summary

Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Located in cytosol; intercellular bridge; and mitotic spindle. [provided by Alliance of Genome Resources, Apr 2022]

NUDCD2 Products (2)

mRNA	Protein	Name
NM_001329991.2	NP_001316920.1	nudC domain-containing protein 2 isoform 2
NM_145266.6	NP_660309.1	nudC domain-containing protein 2 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20133715	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUDCD2 Protein Structure

CS

0
100
157 a.a.

Protein Preferred Names	Protein Names
nudC domain-containing protein 2	NudC-like protein 2

NUDCD2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NUDCD2	Q8WVJ2	DDX3Y	Homo sapiens	O15523	Anti Tag CoIP	33961781
Intra	NUDCD2	Q8WVJ2	DDX3Y	Homo sapiens	O15523	Anti Tag CoIP	28514442
Intra	NUDCD2	Q8WVJ2	HSP90AA1	Homo sapiens	P07900	Pull Down	20133715
Intra	NUDCD2	Q8WVJ2	HSP90AA1	Homo sapiens	P07900	Anti Tag CoIP	20133715
Intra	NUDCD2	Q8WVJ2	HSP90AA1	Homo sapiens	P07900	Anti Bait CoIP	20133715
Intra	NUDCD2	Q8WVJ2	PRMT5	Homo sapiens	O14744	Anti Tag CoIP	23455924
Intra	NUDCD2	Q8WVJ2	PRMT5	Homo sapiens	O14744	Y2H	23455924
Intra	NUDCD2	Q8WVJ2	FBXO24	Homo sapiens	O75426	Lumier	25036637
Intra	NUDCD2	Q8WVJ2	PAFAH1B1	Homo sapiens	P43034	Anti Bait CoIP	20133715
Intra	NUDCD2	Q8WVJ2	PAFAH1B1	Homo sapiens	P43034	Pull Down	20133715
Intra	NUDCD2	Q8WVJ2	PAFAH1B1	Homo sapiens	P43034	Anti Tag CoIP	20133715
Intra	NUDCD2	Q8WVJ2	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
Intra	NUDCD2	Q8WVJ2	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	NUDCD2	Q8WVJ2	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Bardet-Biedl Syndrome 12	BBS12 Bardet-Biedl Syndrome Bbs Bardet-Biedl Syndrome, Type 12

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09659	NUDCD2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NUDCD2	RGD	RGD:1307203
Canis familiaris	NUDCD2	VGNC	VGNC:44023
Felis catus	NUDCD2	VGNC	VGNC:102273
Bos taurus	NUDCD2	VGNC	VGNC:32323
Mus musculus	NUDCD2	MGD	MGI:1277103
Others	NUDCD2	NCBI