PTRH1 - peptidyl-tRNA hydrolase 1 homolog Gene

Also Known as PTH1; C9orf115

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 138428

About PTRH1

This gene has 9 transcripts (splice variants) and 182 orthologues. Broad expression in kidney (RPKM 2.9), testis (RPKM 2.7) and 25 other tissues.

Summary

Enables RNA binding activity. [provided by Alliance of Genome Resources, Apr 2022]

PTRH1 Products (5)

mRNA Protein Name
NM_001002913.3 NP_001002913.1 probable peptidyl-tRNA hydrolase isoform 1
NM_001345977.1 NP_001332906.1 probable peptidyl-tRNA hydrolase isoform 2
NM_001345978.1 NP_001332907.1 probable peptidyl-tRNA hydrolase isoform 3
NM_001345979.1 NP_001332908.1 probable peptidyl-tRNA hydrolase isoform 4
NM_001345980.1 NP_001332909.1 probable peptidyl-tRNA hydrolase isoform 5

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables aminoacyl-tRNA hydrolase activity IDA
IDA: Inferred from direct assay
30244831 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in rescue of stalled ribosome IDA
IDA: Inferred from direct assay
30244831 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTRH1 Protein Structure

Pept_tRNA_hydro

Pept_tRNA_hydro: Peptidyl-tRNA hydrolase (32 - 206)

  • 0
  • 100
  • 200
  • 214 a.a.
Protein Preferred Names Protein Names

probable peptidyl-tRNA hydrolase

  • PTH

PTRH1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PTRH1 Q86Y79 FAM9B Homo sapiens Q8IZU0
Y2H Array
25416956
Intra
PTRH1 Q86Y79 LCN2 Homo sapiens P80188
Y2H Prey Pooling
32296183
Intra
PTRH1 Q86Y79 LCN2 Homo sapiens P80188
Y2H Array
32296183
Intra
PTRH1 Q86Y79 ANKRD28 Homo sapiens O15084
Y2H Array
32296183
Intra
PTRH1 Q86Y79 ANKRD28 Homo sapiens O15084
Y2H Prey Pooling
32296183
Intra
PTRH1 Q86Y79 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
PTRH1 Q86Y79 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra
PTRH1 Q86Y79 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Vascular Skin Disease

  • Skin Diseases, Vascular

  • Skin Vascular Disease
Pancreatic Adenosquamous Carcinoma

  • Adenosquamous Carcinoma Of Pancreas

  • Adenosquamous Carcinoma Of The Pancreas
Non-Syndromic X-Linked Intellectual Disability

  • X-Linked Non-Syndromic Intellectual Disability

  • Non-Specific X-Linked Mental Retardation

  • X-Linked Non-Specific Intellectual Disability
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11453 PTRH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PTRH1 VGNC VGNC:64432
Mus musculus PTRH1 MGD MGI:1913779
Bos taurus PTRH1 VGNC VGNC:33561
Canis familiaris PTRH1 VGNC VGNC:45201
Macaca mulatta PTRH1 VGNC VGNC:76549
Rattus norvegicus PTRH1 RGD RGD:1310165
Others PTRH1 NCBI