Fgl2 - fibrinogen-like protein 2 Gene

Also Known as musfiblp

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14190

Summary

Predicted to enable signaling receptor binding activity. Acts upstream of or within several processes, including T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; negative regulation of antigen processing and presentation; and negative regulation of memory T cell differentiation. Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including extraembryonic component; female reproductive system; lung; nervous system; and vertebral cartilage condensation. Orthologous to human FGL2 (fibrinogen like 2). [provided by Alliance of Genome Resources, Apr 2022]

Fgl2 Products (1)

mRNA Protein Name
NM_008013.4 NP_032039.2 fibroleukin precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IMP
IMP: Inferred from mutant phenotype
29341118 MGI
acts upstream of or within immunoglobulin production involved in immunoglobulin-mediated immune response IMP
IMP: Inferred from mutant phenotype
29341118 MGI
acts upstream of or within negative regulation of defense response to virus IMP
IMP: Inferred from mutant phenotype
29341118 MGI
acts upstream of or within negative regulation of dendritic cell antigen processing and presentation IMP
IMP: Inferred from mutant phenotype
29341118 MGI
acts upstream of or within negative regulation of macrophage antigen processing and presentation IMP
IMP: Inferred from mutant phenotype
29341118 MGI
acts upstream of or within negative regulation of memory T cell differentiation IMP
IMP: Inferred from mutant phenotype
29341118 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fibroleukin

  • associated with MHV-3 induced prothrombinase activity

  • cytotoxic T-lymphocyte-specific protein

  • prothrombinase

Recombinant Fgl2 Proteins

Cat. No. Product Name Accession Purity
HY-P700988 FGL2 Protein, Mouse (Biotinylated, HEK293, His-Avi, Flag) P12804 (P197-P432) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700990 FGL2 Protein, Mouse (HEK293, His-Avi, Flag) P12804 (P197-P432) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04928 FGL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18756 Fgl2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25243 Fgl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fgl2 NCBI NCBI:10875