Fosb - FBJ osteosarcoma oncogene B Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14282

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within cellular response to calcium ion. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; gut; male reproductive gland or organ; skin; and urinary system. Orthologous to human FOSB (FosB proto-oncogene, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Apr 2022]

Fosb Products (2)

mRNA Protein Name
NM_001347586.1 NP_001334515.1 protein FosB isoform 2
NM_008036.2 NP_032062.1 protein FosB isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
12220541 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
12525489 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
12525489 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to calcium ion IDA
IDA: Inferred from direct assay
19303854 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12525489 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein FosB

  • osteosarcoma oncoprotein B FosB

  • protein fosB

  • transcription factor AP-1 subunit FosB

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-179594 HTS10307 Inhibitor / Unkown
HY-W471288 JPC0661 Inhibitor / Unkown
HY-170916 Angiogenesis inhibitor 7 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fosb NCBI NCBI:2354