FBXL14 - F-box and leucine rich repeat protein 14 Gene

Homo sapiens

Also known as Fbl14

Gene ID: 144699 | Gene type: protein coding

About FBXL14

Cytogenetic location: 12p13.33 Genomic coordinates (GRCh38): 12:1,565,993-1,594,842 (from NCBI)

This gene has 2 transcripts (splice variants), 276 orthologues and 15 paralogues. Ubiquitous expression in testis (RPKM 7.1), colon (RPKM 6.6) and 25 other tissues.

Summary

Members of the F-box protein family, such as FBXL14, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

FBXL14 Products(4)

mRNA	Protein	Name
NM_001405291.1	NP_001392220.1	F-box/LRR-repeat protein 14 isoform 2
NM_001405292.1	NP_001392221.1	F-box/LRR-repeat protein 14 isoform 3
NM_001405293.1	NP_001392222.1	F-box/LRR-repeat protein 14 isoform 4
NM_152441.3	NP_689654.1	F-box/LRR-repeat protein 14 isoform 1

FBXL14 Protein Structure

F-box-like

LRR_6

LRR_2

LRR_6

0
100
200
300
418 a.a.

Protein Preferred Names

Protein Names

F-box/LRR-repeat protein 14

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04784	FBXL14 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FBXL14	VGNC	VGNC:54946
Macaca mulatta	FBXL14	VGNC	VGNC:81404
Felis catus	FBXL14	VGNC	VGNC:83880
Bos taurus	FBXL14	VGNC	VGNC:28890
Mus musculus	FBXL14	MGD	MGI:2141676
Rattus norvegicus	FBXL14	RGD	RGD:1305523

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