Usp15 - ubiquitin specific peptidase 15 Gene

Also Known as Gcap18; 4921514G19Rik; E430033I05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14479

Summary

The protein encoded by this gene is a member of the large ubiquitin specific protease (Usp) family of proteins. These proteins are known to cleave ubiquitin, and contain a conserved cysteine residue (Cys box) and two conserved histidine residues (His box) that are thought to form part of the active site of the protease. This protein has been shown to cleave both the ubiquitin-proline and the ubiquitin-methionine bonds in vitro. This protein is thought to regulate many cellular processes through its deubiquitination activity, including the transforming growth factor beta (TGF-beta) pathway. Cardiac-specific overexpression of the human ortholog of this gene in mice causes enlargement of the heart that is more pronounced in the atrium than in the ventricle. This gene has two pseudogenes on chromosome 14. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms.[provided by RefSeq, Aug 2014]

Usp15 Products (2)

mRNA Protein Name
NM_001301628.1 NP_001288557.1 ubiquitin carboxyl-terminal hydrolase 15 isoform 2
NM_027604.4 NP_081880.2 ubiquitin carboxyl-terminal hydrolase 15 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
12532266 MGI
enables deubiquitinase activity IMP
IMP: Inferred from mutant phenotype
32101751 MGI
Biological Process GO Annotation Evidence References Source
involved in protein deubiquitination IMP
IMP: Inferred from mutant phenotype
32101751 MGI
acts upstream of or within regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator IMP
IMP: Inferred from mutant phenotype
32101751 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 15

  • deubiquitinating enzyme 15

  • granule cell antiserum positive 18

  • ubiquitin thioesterase 15

  • ubiquitin thiolesterase 15

  • ubiquitin-specific-processing protease 15

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-180171 USP11-IN-1 Inhibitor / Unkown
HY-184273 TH-407a Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Usp15 NCBI NCBI:9958