Pdpn - podoplanin Gene

Also Known as E11; T1a; Gp38; OTS-8; T1alpha; RANDAM-2; T1-alpha

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14726

Summary

Predicted to enable chaperone binding activity; chemokine binding activity; and signaling receptor binding activity. Involved in several processes, including lymph node development; lymphatic endothelial cell fate commitment; and positive regulation of platelet aggregation. Acts upstream of or within several processes, including lung alveolus development; lymphangiogenesis; and prostaglandin metabolic process. Located in several cellular components, including external side of plasma membrane; lamellipodium; and ruffle. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; hemolymphoid system; and reproductive system. Orthologous to human PDPN (podoplanin). [provided by Alliance of Genome Resources, Apr 2022]

Pdpn Products (2)

mRNA Protein Name
NM_001290822.1 NP_001277751.1 podoplanin isoform 2 precursor
NM_010329.3 NP_034459.2 podoplanin isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables amino acid transmembrane transporter activity IDA
IDA: Inferred from direct assay
12032185 MGI
NOT enables folic acid transmembrane transporter activity IDA
IDA: Inferred from direct assay
12032185 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17616532 MGI
NOT enables water channel activity IDA
IDA: Inferred from direct assay
9651190 MGI
NOT enables water transmembrane transporter activity IDA
IDA: Inferred from direct assay
9651190 MGI
Biological Process GO Annotation Evidence References Source
involved in actin-mediated cell contraction IDA
IDA: Inferred from direct assay
25341788 MGI
NOT involved in amino acid transport IDA
IDA: Inferred from direct assay
12032185 MGI
involved in cell migration IMP
IMP: Inferred from mutant phenotype
10574709 MGI
acts upstream of or within cell population proliferation IMP
IMP: Inferred from mutant phenotype
16869965 MGI
acts upstream of or within cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
16869965 MGI
NOT involved in folic acid transport IDA
IDA: Inferred from direct assay
12032185 MGI
acts upstream of or within lung alveolus development IMP
IMP: Inferred from mutant phenotype
16869965 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
12654292 MGI
involved in lymph node development IMP
IMP: Inferred from mutant phenotype
25347465 MGI
acts upstream of or within lymphangiogenesis IMP
IMP: Inferred from mutant phenotype
12853470 MGI
involved in lymphatic endothelial cell fate commitment IMP
IMP: Inferred from mutant phenotype
20110424 MGI
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
25347465 MGI
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
25347465 MGI
acts upstream of or within positive regulation of cell motility IMP
IMP: Inferred from mutant phenotype
16869965 MGI
involved in positive regulation of platelet aggregation IDA
IDA: Inferred from direct assay
17616532 MGI
involved in positive regulation of platelet aggregation IMP
IMP: Inferred from mutant phenotype
20110424 MGI
acts upstream of or within prostaglandin metabolic process IMP
IMP: Inferred from mutant phenotype
16869965 MGI
acts upstream of or within regulation of G1/S transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
16869965 MGI
involved in regulation of cell adhesion IMP
IMP: Inferred from mutant phenotype
25347465 MGI
involved in regulation of myofibroblast contraction IMP
IMP: Inferred from mutant phenotype
25347465 MGI
involved in regulation of substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
25347465 MGI
acts upstream of or within signal transduction IMP
IMP: Inferred from mutant phenotype
16869965 MGI
NOT acts upstream of or within water transport IDA
IDA: Inferred from direct assay
9651190 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
23180825 MGI
located in filopodium IDA
IDA: Inferred from direct assay
10574709 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
10574709 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
9632596 MGI
located in ruffle IDA
IDA: Inferred from direct assay
10574709 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

podoplanin

  • PA2.26 antigen

  • aggrus

  • glycoprotein 38

  • transmembrane glycoprotein E11

Recombinant Pdpn Proteins

Cat. No. Product Name Accession Purity
HY-P71219 Podoplanin Protein, Mouse (HEK293, Fc) Q62011 (G23-K133) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P73379 Podoplanin Protein, Mouse (sf9, His) Q62011 (M1-K133) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P73704 Podoplanin Protein, Mouse (HEK293, His-Fc) Q62011 (M1-L141) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS17024 Pdpn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-E70294 N-Acetylgalactosaminyltransferase 13 / Unkown
HY-RS10288 PDPN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23467 Pdpn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pdpn NCBI NCBI:10630