PDPN - podoplanin Gene
Also Known as T1A; GP36; GP40; Gp38; OTS8; T1A2; TI1A; D2-40; T1A-2; AGGRUS; HT1A-1; PA2.26
Species: Homo sapiens
About PDPN
This gene has 11 transcripts (splice variants), 83 orthologues and is associated with 1 phenotype. Biased expression in placenta (RPKM 41.5), urinary bladder (RPKM 20.1) and 13 other tissues.
Summary
This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in Other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
PDPN Products (5)
| mRNA | Protein | Name |
|---|---|---|
| NM_001006624.2 | NP_001006625.1 | podoplanin isoform c |
| NM_001006625.2 | NP_001006626.1 | podoplanin isoform d |
| NM_001385053.1 | NP_001371982.1 | podoplanin isoform d |
| NM_006474.5 | NP_006465.4 | podoplanin isoform a precursor |
| NM_198389.2 | NP_938203.2 | podoplanin isoform b |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables chemokine binding |
IPI
IPI: Inferred from physical interaction
|
14978162 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
17046996 | GOA |
| enables protein-folding chaperone binding |
IPI
IPI: Inferred from physical interaction
|
23541579 | GOA |
| enables signaling receptor binding |
IDA
IDA: Inferred from direct assay
|
18215137 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in Rho protein signal transduction |
IMP
IMP: Inferred from mutant phenotype
|
25486435 | GOA |
| involved in positive regulation of cell migration |
IMP
IMP: Inferred from mutant phenotype
|
21376833 | GOA |
| involved in positive regulation of epithelial to mesenchymal transition |
IMP
IMP: Inferred from mutant phenotype
|
17046996 | GOA |
| involved in positive regulation of extracellular matrix disassembly |
IDA
IDA: Inferred from direct assay
|
25486435 | GOA |
| involved in positive regulation of platelet aggregation |
IDA
IDA: Inferred from direct assay
|
17222411 | GOA |
| involved in positive regulation of platelet aggregation |
IMP
IMP: Inferred from mutant phenotype
|
17616532 | GOA |
| involved in regulation of lamellipodium morphogenesis |
IMP
IMP: Inferred from mutant phenotype
|
20962267 | GOA |
| involved in wound healing, spreading of cells |
IMP
IMP: Inferred from mutant phenotype
|
20962267 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in apical plasma membrane |
IDA
IDA: Inferred from direct assay
|
20962267 | GOA |
| located in basolateral plasma membrane |
IDA
IDA: Inferred from direct assay
|
14978162 | GOA |
| located in cell projection |
IDA
IDA: Inferred from direct assay
|
20962267 | GOA |
| located in cytoplasmic vesicle |
IDA
IDA: Inferred from direct assay
|
17046996 | GOA |
| located in cytosol |
IDA
IDA: Inferred from direct assay
|
24275092 | GOA |
| located in filopodium membrane |
IDA
IDA: Inferred from direct assay
|
17046996 | GOA |
| located in lamellipodium membrane |
IDA
IDA: Inferred from direct assay
|
20962267 | GOA |
| located in leading edge of lamellipodium |
IDA
IDA: Inferred from direct assay
|
17046996 | GOA |
| located in membrane |
IDA
IDA: Inferred from direct assay
|
24275092 | GOA |
| located in membrane raft |
IDA
IDA: Inferred from direct assay
|
21376833 | GOA |
| located in microvillus membrane |
IDA
IDA: Inferred from direct assay
|
17046996 | GOA |
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
17046996 | GOA |
| located in ruffle membrane |
IDA
IDA: Inferred from direct assay
|
17046996 | GOA |
| located in tetraspanin-enriched microdomain |
IDA
IDA: Inferred from direct assay
|
18541721 | GOA |
PDPN Protein Structure
Podoplanin: Podoplanin (77 - 238)
- 0
- 100
- 200
- 238 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
podoplanin |
|
PDPN Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
PDPN | Q86YL7 | TMEM14B | Homo sapiens | Q9NUH8 | 32296183 | |
|
Intra
|
PDPN | Q86YL7 | TMEM14B | Homo sapiens | Q9NUH8 | 32296183 | |
|
Intra
|
PDPN | Q86YL7 | TMEM14B | Homo sapiens | Q9NUH8 | 32296183 |
Recombinant PDPN Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P71218 | Podoplanin Protein, Human (HEK293, His) | Q86YL7-1 (A23-L131) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P73378 | Podoplanin Protein, Human (HEK293, His-Fc) | Q86YL7-1 (A23-K123) | ≥ 95%, as determined by reducing SDS-PAGE. |
PDPN Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P85910 | Podoplanin Antibody (YA5602) | IHC-P, WB, ICC/IF, ELISA | Human |
| HY-P85979 | Podoplanin Antibody (YA5671) | IHC-P, ELISA | Human |
| HY-P86249 | Podoplanin Antibody (YA5941) | WB, IHC-P, ICC/IF, IP, ELISA | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Angiosarcoma |
|
|
| Lymphangioma |
|
|
| Chromosome 1p36 Deletion Syndrome |
|
|
| Seminoma |
|
|
| Germinoma |
|
|
| Benign Mesothelioma |
|
|
| Supraglottis Cancer |
|
|
| Subglottis Squamous Cell Carcinoma |
|
|
| Malignant Cystic Nephroma |
|
|
| Supraglottis Neoplasm |
|
|
| Subglottis Benign Neoplasm |
|
|
| Hemangioma |
|
|
| Ovarian Papillary Cystadenoma |
|
|
| Hereditary Lymphedema I |
|
|
| Penile Cancer |
|
|
| Maxillary Sinusitis |
|
|
| Mesothelioma, Malignant |
|
|
| Congenital Lymphedema |
|
|
| Capillary Lymphangioma |
|
|
| Ovarian Papillary Neoplasm |
|
|
| Acquired Hemangioma |
|
|
| Kaposi Sarcoma |
|
|
| Lymphangioleiomyomatosis |
|
|
| Hemangioblastoma |
|
|
| Localized Pulmonary Fibrosis |
|
|
| Hobnail Hemangioma |
|
|
| Lymphangitis |
|
|
| Cystadenocarcinoma |
|
|
| Sarcomatoid Mesothelioma |
|
|
| Squamous Cell Carcinoma |
|
|
| Neurofibroma |
|
|
| Lung Pleomorphic Carcinoma |
|
|
| Lymphangiosarcoma |
|
|
| Gallbladder Papillary Carcinoma |
|
|
| Microinvasive Gastric Cancer |
|
|
| Sclerosing Hepatic Carcinoma |
|
|
| Combined Thymoma |
|
|
| Trichothiodystrophy 1, Photosensitive |
|
|
| Laryngeal Benign Neoplasm |
|
|
| Balanitis Xerotica Obliterans |
|
|
| Congenital Granular Cell Tumor |
|
|
| Verrucous Carcinoma |
|
|
| Gallbladder Cancer |
|
|
| Penile Benign Neoplasm |
|
|
| Signet Ring Cell Adenocarcinoma |
|
|
| Gorham'S Disease |
|
|
| Epiglottis Cancer |
|
|
| Cystic Lymphangioma |
|
|
| Adenocarcinoma In Situ |
|
|
| Xanthogranulomatous Cholecystitis |
|
|
| Gastric Diffuse Adenocarcinoma |
|
|
| Testicular Fibroma |
|
|
| Maxillonasal Dysplasia, Binder Type |
|
|
| Penile Disease |
|
|
| Hereditary Lymphedema |
|
|
| Male Reproductive Organ Benign Neoplasm |
|
|
| Nonencapsulated Sclerosing Carcinoma |
|
|
| Colonic Lymphangioma |
|
|
| Gallbladder Adenocarcinoma |
|
|
| In Situ Carcinoma |
|
|
| Crimean-Congo Hemorrhagic Fever |
|
|
| Lip Cancer |
|
|
| Pre-Malignant Neoplasm |
|
|
| Peritoneal Mesothelioma |
|
|
| Late Congenital Syphilis |
|
|
| Breast Carcinoma In Situ |
|
|
| Ductal Carcinoma In Situ |
|
|
| Colorectal Cancer |
|
|
| Gastric Cancer |
|
|
| Hypopharynx Cancer |
|
|
| Cardiovascular Organ Benign Neoplasm |
|
|
| Diffuse Gastric And Lobular Breast Cancer Syndrome |
|
|
| Ceruminous Adenocarcinoma |
|
|
| Gallbladder Disease |
|
|
| Esophageal Cancer |
|
|
| Benign Peritoneal Mesothelioma |
|
|
| Lymphohistiocytoid Mesothelioma |
|
|
| Breast Cancer |
|
|
| Thymus Sarcomatoid Carcinoma |
|
|
| Meningioma, Familial |
|
|
| Childhood Angiosarcoma |
|
|
| Renal Pelvis Transitional Cell Carcinoma |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
|
| Renal Cell Carcinoma, Papillary, 1 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Felis catus | PDPN | VGNC | VGNC:64095 |
| Macaca mulatta | PDPN | VGNC | VGNC:75884 |
| Canis familiaris | PDPN | VGNC | VGNC:52226 |
| Rattus norvegicus | PDPN | RGD | RGD:61819 |
| Bos taurus | PDPN | VGNC | VGNC:50142 |
| Mus musculus | PDPN | MGD | MGI:103098 |
| Others | PDPN | NCBI |