UBE2U - ubiquitin conjugating enzyme E2 U Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 148581

About UBE2U

This gene has 6 transcripts (splice variants), 109 orthologues and 24 paralogues. Restricted expression toward testis (RPKM 8.1).

Summary

Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in DNA repair; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Predicted to be part of HULC complex. [provided by Alliance of Genome Resources, Apr 2022]

UBE2U Products (5)

mRNA Protein Name
NM_001366232.2 NP_001353161.1 ubiquitin-conjugating enzyme E2 U isoform 1
NM_001366233.2 NP_001353162.1 ubiquitin-conjugating enzyme E2 U isoform 2
NM_001366234.2 NP_001353163.1 ubiquitin-conjugating enzyme E2 U isoform 3
NM_001366235.1 NP_001353164.1 ubiquitin-conjugating enzyme E2 U isoform 5
NM_152489.3 NP_689702.1 ubiquitin-conjugating enzyme E2 U isoform 4

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19549727 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2U Protein Structure

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (9 - 145)

  • 0
  • 100
  • 200
  • 256 a.a.
Protein Preferred Names Protein Names

ubiquitin-conjugating enzyme E2 U

  • E2 ubiquitin-conjugating enzyme U

UBE2U Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
UBE2U Q5VVX9 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Intra
UBE2U Q5VVX9 TRIM32 Homo sapiens Q13049
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Brachydactyly, Type E2

  • Brachydactyly Type E2

  • BDE2

  • Brachydactyly E2
Hypertropia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15363 UBE2U Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus UBE2U MGD MGI:3588216
Bos taurus UBE2U VGNC VGNC:53642
Macaca mulatta UBE2U VGNC VGNC:79726
Rattus norvegicus UBE2U RGD RGD:1565480
Felis catus UBE2U VGNC VGNC:66766
Canis familiaris UBE2U VGNC VGNC:53639
Others UBE2U NCBI