SRARP - steroid receptor associated and regulated protein Gene

Also Known as ERRF; C1orf64

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 149563

About SRARP

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:16,004,236-16,008,807 (from NCBI)

This gene has 1 transcript (splice variant) and 78 orthologues. Biased expression in endometrium (RPKM 2.9), salivary gland (RPKM 2.4) and 4 other tissues.

Summary

Enables Estrogen receptor binding activity. Involved in positive regulation of intracellular Estrogen receptor signaling pathway. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

SRARP Products (1)

mRNA	Protein	Name
NM_178840.4	NP_849162.1	steroid receptor-associated and regulated protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables nuclear estrogen receptor binding	IPI IPI: Inferred from physical interaction	27125460	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of intracellular estrogen receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	27125460	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	22341523	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22341523	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRARP Protein Structure

DUF4654

0
100
169 a.a.

Protein Preferred Names	Protein Names
steroid receptor-associated and regulated protein	ER-related factor

SRARP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SRARP	Q8NEQ6	SLC4A2	Homo sapiens	P04920	Anti Tag CoIP	33961781
Intra	SRARP	Q8NEQ6	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	SRARP	Q8NEQ6	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	SRARP	Q8NEQ6	WFS1	Homo sapiens	O76024	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Lymphocele	Lymph Cyst Lymphocele Adverse Event
Peyronie'S Disease	Induratio Penis Plastica Peyronie Disease Peyronies Disease Peyronie'S Fibromatosis Penile Induration Balanitis Xerotica Obliterans
Urethral Stricture	Ankylurethria Urethral Stenosis Urethral Contracture Urethral Obstruction Meatal Stenosis Nos Constriction Of Urethra Contraction Of Urethra Stricture Of Urinary Meatus Urethral Obliteration Urethral Narrowing Pinpoint Meatus Pinhole Meatus Nos Urethral Occlusion
Laryngomalacia	Congenital Laryngomalacia Congenital Laryngeal Stridor Laryngomalacia Congenital Floppy Epiglottis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13747	SRARP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SRARP	VGNC	VGNC:107639
Rattus norvegicus	SRARP	RGD	RGD:1566083
Canis familiaris	SRARP	VGNC	VGNC:46789
Mus musculus	SRARP	MGD	MGI:2685540
Macaca mulatta	SRARP	VGNC	VGNC:78008
Bos taurus	SRARP	VGNC	VGNC:35267
Others	SRARP	NCBI