SRARP - steroid receptor associated and regulated protein Gene

Also Known as ERRF; C1orf64

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 149563

About SRARP

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:16,004,236-16,008,807 (from NCBI)

This gene has 1 transcript (splice variant) and 78 orthologues. Biased expression in endometrium (RPKM 2.9), salivary gland (RPKM 2.4) and 4 other tissues.

Summary

Enables Estrogen receptor binding activity. Involved in positive regulation of intracellular Estrogen receptor signaling pathway. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

SRARP Products (1)

mRNA Protein Name
NM_178840.4 NP_849162.1 steroid receptor-associated and regulated protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables nuclear estrogen receptor binding IPI
IPI: Inferred from physical interaction
27125460 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of intracellular estrogen receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
27125460 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
22341523 GOA
located in nucleus IDA
IDA: Inferred from direct assay
22341523 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRARP Protein Structure

DUF4654

DUF4654: Domain of unknown function (DUF4654) (32 - 169)

  • 0
  • 100
  • 169 a.a.
Protein Preferred Names Protein Names

steroid receptor-associated and regulated protein

  • ER-related factor

SRARP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SRARP Q8NEQ6 SLC4A2 Homo sapiens P04920
Anti Tag CoIP
33961781
Intra
SRARP Q8NEQ6 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
SRARP Q8NEQ6 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
SRARP Q8NEQ6 WFS1 Homo sapiens O76024
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lymphocele

  • Lymph Cyst

  • Lymphocele Adverse Event
Peyronie'S Disease

  • Induratio Penis Plastica

  • Peyronie Disease

  • Peyronies Disease

  • Peyronie'S Fibromatosis

  • Penile Induration

  • Balanitis Xerotica Obliterans
Urethral Stricture

  • Ankylurethria

  • Urethral Stenosis

  • Urethral Contracture

  • Urethral Obstruction

  • Meatal Stenosis Nos

  • Constriction Of Urethra

  • Contraction Of Urethra

  • Stricture Of Urinary Meatus

  • Urethral Obliteration

  • Urethral Narrowing

  • Pinpoint Meatus

  • Pinhole Meatus Nos

  • Urethral Occlusion
Laryngomalacia

  • Congenital Laryngomalacia

  • Congenital Laryngeal Stridor

  • Laryngomalacia Congenital

  • Floppy Epiglottis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13747 SRARP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SRARP VGNC VGNC:107639
Rattus norvegicus SRARP RGD RGD:1566083
Canis familiaris SRARP VGNC VGNC:46789
Mus musculus SRARP MGD MGI:2685540
Macaca mulatta SRARP VGNC VGNC:78008
Bos taurus SRARP VGNC VGNC:35267
Others SRARP NCBI