CTRL - chymotrypsin like Gene

Also Known as CTRL1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1506

About CTRL

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:67,929,574-67,931,862 (from NCBI)

This gene has 8 transcripts (splice variants), 202 orthologues and 1 paralogue. Restricted expression toward pancreas (RPKM 884.9).

Summary

This gene encodes a serine-type endopeptidase with chymotrypsin- and elastase-2-like activities. The gene encoding this zymogen is expressed specifically in the pancreas and likely functions as a digestive enzyme. [provided by RefSeq, Sep 2016]

CTRL Products (1)

mRNA Protein Name
NM_001907.3 NP_001898.1 chymotrypsin-like protease CTRL-1 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables serine-type peptidase activity IDA
IDA: Inferred from direct assay
9065485 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
9065485 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CTRL Protein Structure

Trypsin

Trypsin: Trypsin (34 - 257)

  • 0
  • 100
  • 200
  • 264 a.a.
Protein Preferred Names Protein Names

chymotrypsin-like protease CTRL-1

CTRL Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CTRL P40313 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
CTRL P40313 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
Intra
CTRL P40313 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
CTRL P40313 CLDN5 Homo sapiens O00501
Y2H Array
32296183
Intra
CTRL P40313 CLDN5 Homo sapiens O00501
Y2H Prey Pooling
32296183
Intra
CTRL P40313 FATE1 Homo sapiens Q969F0
Y2H Prey Pooling
32296183
Intra
CTRL P40313 FATE1 Homo sapiens Q969F0
Validated Y2H
32296183
Intra
CTRL P40313 FATE1 Homo sapiens Q969F0
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CTRL Proteins

Cat. No. Product Name Accession Purity
HY-P70033 CTRL-1 Protein, Human (HEK293, His) P40313 (C19-N264) ≥ 95%, as determined by reducing SDS-PAGE.

CTRL Antibodies

Cat. No. Product Name Application Reactivity
HY-P82922 CTRL Antibody (YA2667) WB Human, Mouse, Rat

Related Diseases

Diseases Alias
Netherton Syndrome

  • NETH

  • Ns

  • Netherton Disease

  • Comel-Netherton Syndrome

  • Erythroderma, Ichthyosiform, With Hypotrichosis And Hyper-Ige

  • Bamboo Hair Syndrome

  • Ichthyosis Linearis Circumflexa

  • Ichthyosiform Erythroderma With Hypotrichosis And Hyper-Ige

  • Ilc

  • Nts

  • N Syndrome
Necrotizing Ulcerative Gingivitis

  • Acute Necrotizing Ulcerative Gingivitis

  • Anug

  • Vincent Angina

  • Vincent'S Disease

  • Acute Necrotising Ulcerative Gingivitis

  • Acute Necrotising Ulcerative Gingivostomatitis

  • Acute Necrotizing Ulcerative Gingivostomatitis

  • Acute Ulceromembranous Gingivitis

  • Angina - Vincents

  • Early Acute Necrotising Gingivitis

  • Trench Mouth

  • Vincent'S Angina

  • Vincent'S Angina - Pharyngitis

  • Vincent'S Infection, Any Site

  • Acute Membranous Gingivitis

  • Fusospirillary Gingivitis

  • Fusospirillosis

  • Phagedenic Gingivitis

  • Vincent'S Gingivitis

  • Vincent'S Infection

  • Vincent'S Stomatitis

  • Gingivitis, Necrotizing Ulcerative
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Cataract

  • Cataracts

  • Cat - [Cataract]

  • Cataract Form

  • Lens Opacity

  • Lens Opacities
Mantle Cell Lymphoma

  • Lymphoma, Mantle Cell

  • Lcm

  • Mcl

  • Mantle Zone Lymphoma

  • Lymphoma Mantle-Cell

  • Lymphoma, Mantle-Cell

  • Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse

  • Malignant Lymphoma - Lymphocytic, Intermediate Differentiation

  • Diffuse Small Cleaved-Cell Lymphoma

  • Diffuse Small Cleaved Cell Malignant Lymphoma

  • Small Cleaved Cell Non-Hodgkin Lymphoma

  • Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma

  • Malignant Lymphomatous Polyposis

  • Malignant Small Cell, Noncleaved, Diffuse Lymphoma

  • Malignant Undifferentiated Cell, Non-Burkitt Lymphoma

  • Cleaved Cell Lymphoma

  • Small Cell Mantle Cell Lymphoma

  • Small Cleaved Cell Malignant Lymphoma
Alzheimer Disease, Familial, 1

  • Alzheimer Disease

  • Alzheimer'S Disease

  • Presenile And Senile Dementia

  • AD1

  • Alzheimer Disease, Susceptibility To

  • Alzheimer Disease, Late-Onset, Susceptibility To

  • Alzheimer Disease 1, Familial

  • AD

  • Familial Alzheimer Disease

  • Alzheimer Disease, Late-Onset

  • Alzheimers Dementia

  • Alzheimer Dementia

  • Alzheimer Sclerosis

  • Alzheimer Syndrome

  • Alzheimer-Type Dementia

  • Dat

  • Primary Senile Degenerative Dementia

  • Sdat

  • Alzheimer Disease 1

  • Autosomal Dominant Alzheimer Disease

  • Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

  • Late Onset Alzheimer Disease

  • Alzheimers Disease

  • Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

  • Late-Onset Alzheimers Disease

  • Alzheimer'S Disease Pathway Kegg

  • Dementia Due To Alzheimer'S Disease

  • Alzheimer Disease Type 1

  • Alzheimers
Nervous System Disease

  • Abnormality Of The Nervous System

  • Nervous System Diseases

  • Nervous System Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-150087 Ctrl-CF4-S2 / Unkown
HY-D3217 Ctrl-CSF1 / Unkown
HY-D3219 Ctrl-CPF1 / Unkown
HY-D3233 Ctrl-BDPS1 / Unkown
HY-D3281 Ctrl-CSR1 / Unkown
HY-D3283 Ctrl-CCF1 / Unkown
HY-RS03320 CTRL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19316 Ctrl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25807 Ctrl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CTRL VGNC VGNC:39707
Macaca mulatta CTRL VGNC VGNC:71551
Mus musculus CTRL MGD MGI:88558
Felis catus CTRL VGNC VGNC:61264
Rattus norvegicus CTRL RGD RGD:621501
Others CTRL NCBI