2. Gene
  3. CTSH - cathepsin H Gene

CTSH - cathepsin H Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ACC4; ACC5; CPSB; ACC-4; ACC-5

Gene ID: 1512 | Gene type: protein coding

About CTSH

Cytogenetic location: 15q25.1 Genomic coordinates (GRCh38): 15:78,921,058-78,945,046 (from NCBI)

This gene has 69 transcripts (splice variants), 225 orthologues, 12 paralogues and is associated with 1 phenotype. Broad expression in lung (RPKM 144.1), kidney (RPKM 97.7) and 24 other tissues.

Summary

The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and LIGHT chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an Aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

CTSH Products(3)

mRNA Protein Name
NM_001319137.2 NP_001306066.1 pro-cathepsin H isoform c
NM_001411095.1 NP_001398024.1 pro-cathepsin H isoform d
NM_004390.5 NP_004381.2 pro-cathepsin H isoform a preproprotein

CTSH Protein Structure

Inhibitor_I29

Inhibitor_I29: Cathepsin propeptide inhibitor domain (I29) (35 - 89)

Peptidase_C1

Peptidase_C1: Papain family cysteine protease (117 - 332)

  • 0
  • 100
  • 200
  • 300
  • 335 a.a.
Protein Preferred Names Protein Names

pro-cathepsin H

N-benzoylarginine-beta-naphthylamide hydrolase

Recombinant CTSH Proteins

Cat. No. Product Name Accession Purity
HY-P79273 Cathepsin H Protein, Human (CHO, His) CAA34734 (A23-V335) ≥95%

Related Diseases

Diseases Alias
Narcolepsy 1

NRCLP1

Narcoleptic Syndrome 1

Gelineau Disease

Narcolepsy-Cataplexy

Narcolepsy-Cataplexy Syndrome

Narcolepsy, Type 1

Narcolepsy Type 1

Cataplexy

Gélineau'S Syndrome

Narcolepsy With Cataplexy And/Or Hypocretin Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-E70227 Cathepsin G, human neutrophils / Unkown
HY-RS03336 CTSH Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CTSH RGD RGD:2447
Bos taurus CTSH VGNC VGNC:27816
Canis familiaris CTSH VGNC VGNC:39713
Macaca mulatta CTSH VGNC VGNC:71558
Felis catus CTSH VGNC VGNC:61268
Mus musculus CTSH MGD MGI:107285
Others CTSH NCBI