PYDC2 - pyrin domain containing 2 Gene

Also Known as POP2; cPOP2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 152138

Summary

Involved in negative regulation of inflammatory response; negative regulation of interleukin-1 beta production; and negative regulation of signal transduction. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Jun 2026]

PYDC2 Products (1)

mRNA Protein Name
NM_001083308.1 NP_001076777.1 pyrin domain-containing protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17178784 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
17339483 GOA
involved in negative regulation of NLRP3 inflammasome complex assembly IMP
IMP: Inferred from mutant phenotype
17339483 GOA
involved in negative regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
17178784 GOA
involved in negative regulation of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
17178784 GOA
involved in negative regulation of non-canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
17339483 GOA
involved in negative regulation of tumor necrosis factor-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
17339483 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17178784 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17178784 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PYDC2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PYDC2 Q56P42 NLRP2 Homo sapiens Q9NX02
Anti Tag CoIP
17178784
Intra
PYDC2 Q56P42 NLRP2 Homo sapiens Q9NX02
Pull Down
17178784
Intra
PYDC2 Q56P42 PYCARD Homo sapiens Q9ULZ3
Confocal
17178784
Intra
PYDC2 Q56P42 PYCARD Homo sapiens Q9ULZ3
Y2H
17178784
Cross: Cross-species interaction Intra: Intraspecies interaction