CMTM8 - CKLF like MARVEL transmembrane domain containing 8 Gene

Also Known as CKLFSF8; CKLFSF8-V2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 152189

About CMTM8

Cytogenetic location: 3p22.3 Genomic coordinates (GRCh38): 3:32,238,192-32,370,321 (from NCBI)

This gene has 2 transcripts (splice variants), 217 orthologues and 14 paralogues. Broad expression in liver (RPKM 5.0), lung (RPKM 5.0) and 23 other tissues.

Summary

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene acts as a tumor suppressor, and plays a role in regulating the migration of tumor cells. The encoded protein is thought to function as a a negative regulator of epidermal growth factor-induced signaling. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

CMTM8 Products (2)

mRNA	Protein	Name
NM_001320308.2	NP_001307237.1	CKLF-like MARVEL transmembrane domain-containing protein 8 isoform 2
NM_178868.5	NP_849199.2	CKLF-like MARVEL transmembrane domain-containing protein 8 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CMTM8 Protein Structure

MARVEL

0
100
173 a.a.

Protein Preferred Names	Protein Names
CKLF-like MARVEL transmembrane domain-containing protein 8	chemokine-like factor superfamily member 8

CMTM8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CMTM8	Q8IZV2	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	CMTM8	Q8IZV2	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	CMTM8	Q8IZV2	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	CMTM8	Q8IZV2	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	CMTM8	Q8IZV2	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Brugada Syndrome 2	BRGDA2 Brugada Syndrome, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02870	CMTM8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CMTM8	VGNC	VGNC:39384
Rattus norvegicus	CMTM8	RGD	RGD:735040
Macaca mulatta	CMTM8	VGNC	VGNC:71219
Mus musculus	CMTM8	MGD	MGI:2447167
Bos taurus	CMTM8	VGNC	VGNC:27488