Hgf - hepatocyte growth factor Gene

Also Known as SF; NK1; NK2; HGF/SF; SF/HGF; C230052L06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15234

Summary

This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the hepatocyte growth factor alpha and beta chains, which heterodimerize to form the mature active protein. Although this protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Homozygous knockout mice for this gene exhibit embryonic lethality due to impaired development of the placenta and liver. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

Hgf Products (5)

mRNA Protein Name
NM_001289458.1 NP_001276387.1 hepatocyte growth factor isoform 1 preproprotein
NM_001289459.1 NP_001276388.1 hepatocyte growth factor isoform 1 preproprotein
NM_001289460.2 NP_001276389.1 hepatocyte growth factor isoform 2 precursor
NM_001289461.1 NP_001276390.1 hepatocyte growth factor isoform 3 preproprotein
NM_010427.5 NP_034557.3 hepatocyte growth factor isoform 1 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17804794 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell morphogenesis IDA
IDA: Inferred from direct assay
12130561 MGI
acts upstream of or within epithelial cell proliferation IDA
IDA: Inferred from direct assay
12130561 MGI
acts upstream of or within hepatocyte growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
15314156 MGI
acts upstream of or within liver development IDA
IDA: Inferred from direct assay
16880525 MGI
acts upstream of or within myoblast proliferation IDA
IDA: Inferred from direct assay
11061428 MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
IDA: Inferred from direct assay
15314156 MGI
acts upstream of or within negative regulation of inflammatory response IDA
IDA: Inferred from direct assay
21072211 MGI
acts upstream of or within negative regulation of interleukin-6 production IDA
IDA: Inferred from direct assay
21072211 MGI
acts upstream of or within negative regulation of peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
21072211 MGI
acts upstream of or within positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
15314156 MGI
acts upstream of or within positive regulation of interleukin-10 production IDA
IDA: Inferred from direct assay
21072211 MGI
acts upstream of or within regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling IMP
IMP: Inferred from mutant phenotype
14517989 MGI
acts upstream of or within regulation of p38MAPK cascade IDA
IDA: Inferred from direct assay
23994610 MGI
acts upstream of or within regulation of tau-protein kinase activity IDA
IDA: Inferred from direct assay
21072211 MGI
acts upstream of or within skeletal muscle cell proliferation IDA
IDA: Inferred from direct assay
11061428 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hepatocyte growth factor

  • hepatopoietin-A

  • scatter factor

Recombinant Hgf Proteins

Cat. No. Product Name Accession Purity
HY-P70561 HGF Protein, Mouse (HEK293, His) Q08048-1 (Q33-L728) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P73928 HGF Protein, Mouse (HEK293) Q08048-1 (Q33-L728) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-A0020 Eldecalcitol 99.94% Yes

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-137455 Terevalefim Activator 99.37% Phase 3
HY-18696 AMG-337 99.40% Phase 2
Inhibitory Antibodies (7)
Cat. No. Product Name Effect
Purity Phase
HY-P99391 Telisotuzumab 99.91% Phase 3
HY-P99250 Onartuzumab Inhibitor 99.62% Phase 3
HY-P99196 Ficlatuzumab Inhibitor 96.54% Phase 3
HY-P99217 Rilotumumab Inhibitor 99.10% Phase 3
HY-P99192 Emibetuzumab Inhibitor 95.00% Phase 2
HY-P990949 Umikibart 98.70% Phase 2
HY-P991660 ARGX-111 Inhibitor 99.25% Phase 1

Pre-clinical Phase

Bioactive Molecules (38)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-16969 Dihexa Activator 98.92% Unkown
HY-106961 ONO 1301 Agonist 99.02% Unkown
HY-114363A SRI 31215 TFA Inhibitor 98.35% Unkown
HY-12017 PF-04217903 99.85% Unkown
HY-P1415A Norleual TFA 99.52% Unkown
HY-12017A PF-04217903 mesylate 99.82% Unkown
HY-176901 HGF-IN-1 Inhibitor 98.01% Unkown
HY-106961A (Z)-ONO 1301 Agonist 98.13% Unkown
HY-145263 VD2173 Inhibitor / Unkown
HY-154988 MARK4 inhibitor 4 99.23% Unkown
HY-RS13576 SOS1 Human Pre-designed siRNA Set A / Unkown
HY-N13286 Glycozolidal Inhibitor 99.92% Unkown
HY-12017B PF-04217903 phenolsulfonate / Unkown
HY-10338A Foretinib phosphate Inhibitor / Unkown
HY-114363 SRI 31215 Inhibitor / Unkown
HY-120159 GS-493 Inhibitor / Unkown
HY-165284 CM-118 Inhibitor / Unkown
HY-E70748 MET D1228H Recombinant Human Active Protein Kinase / Unkown
HY-E70749 MET D1228N Recombinant Human Active Protein Kinase / Unkown
HY-E70750 MET F1200I Recombinant Human Active Protein Kinase / Unkown
HY-E70751 MET G1163R Recombinant Human Active Protein Kinase / Unkown
HY-E70752 MET L1195V Recombinant Human Active Protein Kinase / Unkown
HY-E70753 MET M1250T Recombinant Human Active Protein Kinase / Unkown
HY-E70754 MET Y1230A Recombinant Human Active Protein Kinase / Unkown
HY-E70755 MET Y1230C Recombinant Human Active Protein Kinase / Unkown
HY-E70756 MET Y1230D Recombinant Human Active Protein Kinase / Unkown
HY-E70757 MET Y1230H Recombinant Human Active Protein Kinase / Unkown
HY-E70758 MET Y1235D Recombinant Human Active Protein Kinase / Unkown
HY-N17359 Mulberrofuran W / Unkown
HY-N17854 3β-O-α-L-Arabinopyranosylsiaresinolic acid 28-O-β-D-glucopyranosyl ester / Unkown
HY-P1415 Norleual / Unkown
HY-RS06152 HGF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06774 IL6 Human Pre-designed siRNA Set A / Unkown
HY-RS08346 Met Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-12017C PF-04217903 phosphate / Unkown
HY-174670 Human HGF mRNA / Unkown
HY-RS16504 Hgf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22936 Hgf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991589 SFN68 Inhibitor 99.87% Unkown
HY-P991565 CE-355621 Inhibitor / Unkown
HY-P992396 KTN0073 Inhibitor / Unkown
HY-P99391A Telisotuzumab (powder) / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hgf NCBI NCBI:3082