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ZNF746 - zinc finger protein 746 Gene

Also Known as PARIS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 155061

About ZNF746

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:149,472,696-149,497,809 (from NCBI)

This gene has 6 transcripts (splice variants), 107 orthologues and 51 paralogues. Broad expression in testis (RPKM 10.6), bone marrow (RPKM 6.7) and 25 other tissues.

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and ubiquitin protein Ligase binding activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of neuron death; and positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ZNF746 Products (4)

mRNA	Protein	Name
NM_001163474.2	NP_001156946.1	zinc finger protein 746 isoform 1
NM_001363517.2	NP_001350446.1	zinc finger protein 746 isoform 3
NM_001394198.1	NP_001381127.1	zinc finger protein 746 isoform 4
NM_152557.5	NP_689770.3	zinc finger protein 746 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	21376232	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	21376232	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	21376232	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21376232	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	21376232	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	21376232	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	31856708	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21376232	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21376232	GOA
involved in protein heterooligomerization	IDA IDA: Inferred from direct assay	31856708	GOA
involved in protein homooligomerization	IDA IDA: Inferred from direct assay	31856708	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21376232	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF746 Protein Structure

DUF3669

KRAB

zf-C2H2

zf-H2C2_2

zf-C2H2

0
100
200
300
400
500
600
644 a.a.

Protein Preferred Names	Protein Names
zinc finger protein 746	parkin-interacting substrate

ZNF746 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ZNF746	Q6NUN9	PRKN	Homo sapiens	O60260	Pull Down	21376232
Intra	ZNF746	Q6NUN9	PRKN	Homo sapiens	O60260	Anti Tag CoIP	21376232
Intra	ZNF746	Q6NUN9	PRKN	Homo sapiens	O60260	Anti Bait CoIP	21376232

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16172	ZNF746 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ZNF746	VGNC	VGNC:37339
Felis catus	ZNF746	VGNC	VGNC:80767
Rattus norvegicus	ZNF746	RGD	RGD:1306209
Mus musculus	ZNF746	MGD	MGI:1916478