2. Gene
  3. Casp12 - caspase 12 Gene

Casp12 - caspase 12 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 156117 | Gene type: protein coding

About Casp12

Primary_assembly 8: 2,642,434-2,674,037 forward strand.mRatBN7.2:CM026981.1

This gene has 3 transcripts (splice variants), 273 orthologues, 12 paralogues and is associated with 31 phenotypes. Biased expression in Adrenal (RPKM 149.4), Liver (RPKM 16.3) and 8 other tissues.

Summary

Enables cysteine-type peptidase activity; endopeptidase activity; and protease binding activity. Involved in several processes, including cellular response to manganese ion; positive regulation of striated muscle cell apoptotic process; and protein autoprocessing. Located in cytosol and nucleus. Used to study sciatic neuropathy. Biomarker of several diseases, including diabetes mellitus (multiple); heart disease (multiple); neurodegenerative disease (multiple); post-traumatic stress disorder; and ureteral obstruction. Orthologous to human CASP12 (Caspase 12 (gene/pseudogene)). [provided by Alliance of Genome Resources, Apr 2022]

Casp12 Products(1)

mRNA Protein Name
NM_130422.1 NP_569106.1 caspase-12

Casp12 Protein Structure

CARD_CASP1-like

CARD_CASP1-like: cd08325 (5 - 87)

CASc

CASc: smart00115 (166 - 417)

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  • 420 a.a.
Protein Preferred Names Protein Names

caspase-12

CASP-12

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01945 CASP12 Human Pre-designed siRNA Set A / Unkown
HY-RS01946 Casp12 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01947 Casp12 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Casp12 NCBI NCBI:100506742