Casp12 - caspase 12 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 156117

About Casp12

Primary_assembly 8: 2,642,434-2,674,037 forward strand.mRatBN7.2:CM026981.1

This gene has 3 transcripts (splice variants), 273 orthologues, 12 paralogues and is associated with 31 phenotypes. Biased expression in Adrenal (RPKM 149.4), Liver (RPKM 16.3) and 8 other tissues.

Summary

Enables cysteine-type peptidase activity; endopeptidase activity; and protease binding activity. Involved in several processes, including cellular response to manganese ion; positive regulation of striated muscle cell apoptotic process; and protein autoprocessing. Located in cytosol and nucleus. Used to study sciatic neuropathy. Biomarker of several diseases, including diabetes mellitus (multiple); heart disease (multiple); neurodegenerative disease (multiple); post-traumatic stress disorder; and ureteral obstruction. Orthologous to human CASP12 (Caspase 12 (gene/pseudogene)). [provided by Alliance of Genome Resources, Apr 2022]

Casp12 Products (1)

mRNA Protein Name
NM_130422.1 NP_569106.1 caspase-12

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables cysteine-type peptidase activity IDA
IDA: Inferred from direct assay
18316105 RGD
enables endopeptidase activity IDA
IDA: Inferred from direct assay
18332441 RGD
enables protease binding IDA
IDA: Inferred from direct assay
18332441 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
20818395 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
29568958 RGD
involved in cellular response to manganese ion IEP
IEP: Inferred from expression pattern
23934647 RGD
involved in intrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
10638761 RGD
involved in luteolysis IEP
IEP: Inferred from expression pattern
25332219 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
17083921 RGD
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
17083921 RGD
involved in positive regulation of striated muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
26801321 RGD
involved in protein autoprocessing IDA
IDA: Inferred from direct assay
18332441 RGD
involved in protein catabolic process IDA
IDA: Inferred from direct assay
18316105 RGD
involved in response to anoxia IEP
IEP: Inferred from expression pattern
17083921 RGD
involved in response to endoplasmic reticulum stress IEP
IEP: Inferred from expression pattern
16979584 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
17433554 RGD
involved in response to iron(III) ion IEP
IEP: Inferred from expression pattern
19594550 RGD
involved in response to kainic acid IEP
IEP: Inferred from expression pattern
17251432 RGD
involved in response to nicotine IEP
IEP: Inferred from expression pattern
18477628 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
16236330 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Casp12 Protein Structure

CARD_CASP1-like

CARD_CASP1-like: cd08325 (5 - 87)

CASc

CASc: smart00115 (166 - 417)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 420 a.a.
Protein Preferred Names Protein Names

caspase-12

  • CASP-12

Casp12 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Casp12 Q920D5 RIGI Homo sapiens O95786
IF
20818395
Cross
Casp12 Q920D5 RIGI Homo sapiens O95786
Pull Down
20818395
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P11596 NOTA-Asp2-αvβ6L / Unkown
HY-RS01945 CASP12 Human Pre-designed siRNA Set A / Unkown
HY-RS01946 Casp12 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01947 Casp12 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Casp12 NCBI NCBI:100506742