Ide - insulin degrading enzyme Gene

Also Known as 1300012G03Rik; 4833415K22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15925

Summary

Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and peptide binding activity. Involved in Insulin catabolic process. Acts upstream of or within amyloid-beta clearance and response to oxidative stress. Located in extracellular exosome. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to human IDE (Insulin degrading enzyme). [provided by Alliance of Genome Resources, Apr 2022]

Ide Products (1)

mRNA Protein Name
NM_031156.4 NP_112419.4 insulin-degrading enzyme

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables endopeptidase activity IDA
IDA: Inferred from direct assay
27703010 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within amyloid-beta clearance IDA
IDA: Inferred from direct assay
26637123 MGI
involved in amyloid-beta clearance IMP
IMP: Inferred from mutant phenotype
20876579 MGI
involved in insulin catabolic process IDA
IDA: Inferred from direct assay
27703010 MGI
involved in insulin catabolic process IMP
IMP: Inferred from mutant phenotype
24847884 MGI
involved in insulin receptor recycling IDA
IDA: Inferred from direct assay
27703010 MGI
involved in protein catabolic process IMP
IMP: Inferred from mutant phenotype
20876579 MGI
acts upstream of or within response to oxidative stress IDA
IDA: Inferred from direct assay
26637123 MGI
Cellular Component GO Annotation Evidence References Source
is active in endosome lumen IDA
IDA: Inferred from direct assay
27703010 MGI
located in extracellular exosome IMP
IMP: Inferred from mutant phenotype
20876579 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

insulin-degrading enzyme

  • insulin protease

  • insulinase

  • insulysin

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-101569 Darovasertib Inhibitor 99.78% Phase 3
HY-169422 GSK4418959 Inhibitor 99.07% Phase 2

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N7135 Tropolone Inhibitor 99.98% Unkown
HY-100533 IDE1 99.13% Unkown
HY-110197 6bK TFA Inhibitor 99.68% Unkown
HY-100534 IDE 2 Agonist 99.00% Unkown
HY-117878 ML345 Inhibitor 99.37% Unkown
HY-W157689 IDE-IN-2 Inhibitor 98.04% Unkown
HY-169422A GSK4418959 (enantiomer) 95.0% Unkown
HY-W038421 1,3-Bis(2,4,6-trimethylphenyl)-1,3-dihydro-2H-imidazol-2-ylidene ≥98.0% Unkown
HY-110197A 6bK formate Inhibitor 97.02% Unkown
HY-114611 BDM44768 / Unkown
HY-12655 IDE-IN-1 Inhibitor / Unkown
HY-143401 Hit 1 Activator / Unkown
HY-182280 BDM71230 / Unkown
HY-RS06526 IDE Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W616806 Sodium 6-oxo-3,6-dihydropurin-7-ide / Unkown
HY-RS16920 Ide Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23363 Ide Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992056 Anti-Human/Mouse LY6E Antibody (9B12) / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ide NCBI NCBI:3416