REM2 - RRAD and GEM like GTPase 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 161253

About REM2

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:22,883,222-22,887,678 (from NCBI)

This gene has 2 transcripts (splice variants), 251 orthologues and 35 paralogues. Broad expression in bone marrow (RPKM 2.3), spleen (RPKM 0.7) and 14 other tissues.

Summary

Predicted to enable GTP binding activity and Calcium Channel regulator activity. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

REM2 Products (1)

mRNA Protein Name
NM_173527.3 NP_775798.2 GTP-binding protein REM 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

REM2 Protein Structure

Ras

Ras: Ras family (116 - 277)

  • 0
  • 100
  • 200
  • 300
  • 340 a.a.
Protein Preferred Names Protein Names

GTP-binding protein REM 2

  • RAS (RAD and GEM)-like GTP binding 2

REM2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
REM2 Q8IYK8 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
REM2 Q8IYK8 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
REM2 Q8IYK8 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
REM2 Q8IYK8 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Long Qt Syndrome

  • Romano-Ward Syndrome

  • Long Q-T Syndrome

  • Lqt

  • Qt Syndrome, Long

  • Congenital Long Qt Syndrome

  • Familial Long Qt Syndrome
Long Qt Syndrome 2

  • LQT2

  • Long Qt Syndrome, Acquired, Reduced Susceptibility To

  • Long Qt Syndrome 1/2

  • Long Qt Syndrome 2/3

  • Long Qt Syndrome 2/5

  • Long Qt Syndrome 2, Acquired, Susceptibility To

  • Long Qt Syndrome, Acquired, Reduced

  • Long Qt Syndrome Type 2

  • Long Qt Syndrome 2/9

  • Lqt1/2

  • Lqt2/3

  • Lqt2/5

  • Lqt2/9

  • Susceptibility To Acquired Long Qt Syndrome 2

  • Long Qt Syndrome-2

  • Qt Syndrome, Long, Type 2

  • Long Qt Syndrome 1-2

  • Long Qt Syndrome 2-3

  • Long Qt Syndrome 2-5

  • Long Qt Syndrome 9
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11838 REM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17645 Rem2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24105 Rem2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus REM2 MGD MGI:2155260
Rattus norvegicus REM2 RGD RGD:69081
Canis familiaris REM2 VGNC VGNC:45473
Felis catus REM2 VGNC VGNC:64570
Macaca mulatta REM2 VGNC VGNC:82220
Bos taurus REM2 VGNC VGNC:33864
Others REM2 NCBI