AKR1C2 - aldo-keto reductase family 1 member C2 Gene

Also Known as DD; DD2; TDD; BABP; DD-2; DDH2; HBAB; HAKRD; MCDR2; SRXY8; DD/BABP; AKR1C-pseudo

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1646

About AKR1C2

Cytogenetic location: 10p15.1 Genomic coordinates (GRCh38): 10:4,987,775-5,018,000 (from NCBI)

This gene has 10 transcripts (splice variants), 463 orthologues, 16 paralogues and is associated with 2 phenotypes. Biased expression in fat (RPKM 84.8), liver (RPKM 37.2) and 10 other tissues.

Summary

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known Enzymes and proteins. These Enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The Enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three Other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

AKR1C2 Products (5)

mRNA	Protein	Name
NM_001135241.3	NP_001128713.1	aldo-keto reductase family 1 member C2 isoform 2
NM_001321027.2	NP_001307956.1	aldo-keto reductase family 1 member C2 isoform 3
NM_001354.6	NP_001345.1	aldo-keto reductase family 1 member C2 isoform 1
NM_001393392.1	NP_001380321.1	aldo-keto reductase family 1 member C2 isoform 1
NM_205845.3	NP_995317.1	aldo-keto reductase family 1 member C2 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables aldose reductase (NADPH) activity	IDA IDA: Inferred from direct assay	21232532	GOA
enables bile acid binding	IDA IDA: Inferred from direct assay	8573067	GOA
enables carboxylic acid binding	IDA IDA: Inferred from direct assay	8573067	GOA
enables ketosteroid monooxygenase activity	IDA IDA: Inferred from direct assay	21232532	GOA
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	IDA IDA: Inferred from direct assay	20837989	GOA
enables trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	IDA IDA: Inferred from direct assay	8573067	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	18508192	GOA
involved in cellular response to jasmonic acid stimulus	IDA IDA: Inferred from direct assay	19487289	GOA
involved in cellular response to prostaglandin D stimulus	IDA IDA: Inferred from direct assay	18508192	GOA
involved in daunorubicin metabolic process	IMP IMP: Inferred from mutant phenotype	20837989	GOA
involved in digestion	IDA IDA: Inferred from direct assay	8573067	GOA
involved in doxorubicin metabolic process	IMP IMP: Inferred from mutant phenotype	20837989	GOA
involved in epithelial cell differentiation	IEP IEP: Inferred from expression pattern	21492153	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	18508192	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	18508192	GOA
involved in progesterone metabolic process	IDA IDA: Inferred from direct assay	21232532	GOA
involved in prostaglandin metabolic process	IDA IDA: Inferred from direct assay	8573067	GOA
involved in steroid metabolic process	IDA IDA: Inferred from direct assay	8573067	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AKR1C2 Protein Structure

Aldo_ket_red

0
100
200
300
323 a.a.

Protein Preferred Names	Protein Names
aldo-keto reductase family 1 member C2	3-alpha-HSD3

Recombinant AKR1C2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7469	AKR1C2 Protein, Human	P52895 (M1-Y323)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P75520	AKR1C2 Protein, Human (His)	P52895 (M1-Y323)	≥ 90%, as determined by reducing SDS-PAGE.

AKR1C2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82930	AKR1C1/AKR1C2 Antibody (YA2675)	WB, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
46,Xy Sex Reversal 8	SRXY8 Male Pseudohermaphroditism Due To Deficiency Of Testicular 17,20-Desmolase Tdd 46,Xy Disorder Of Sex Development Due To Testicular 17,20-Desmolase Deficiency 46xy Sex Reversal 8 46xy Sex Reversal 8, Modifier Of Male Pseudohermaphroditism: Deficiency Of Testicular 17,20-Desmolase
46,Xy Sex Reversal	Swyer Syndrome Pure Gonadal Dysgenesis 46,Xy Gonadal Dysgenesis, Xy Female Type Gonadal Dysgenesis, 46,Xy 46,Xy Cgd 46,Xy Complete Gonadal Dysgenesis 46,Xy Pure Gonadal Dysgenesis 46 Xy Gonadal Dysgenesis 46, Xy Cgd 46, Xy Complete Gonadal Dysgenesis 46, Xy Pure Gonadal Dysgenesis Xy Pure Gonadal Dysgenesis Female With 46,Xy Karyotype Xy Females
Parasitic Protozoa Infectious Disease	Protozoan Infections Mastigophora Infectious Disease Sarcomastigophora Infectious Disease
Short-Rib Thoracic Dysplasia 2 With Or Without Polydactyly	Asphyxiating Thoracic Dystrophy 2 SRTD2 Atd2 Jatd Jeune Asphyxiating Thoracic Dystrophy Jeune Syndrome 2
Glucosephosphate Dehydrogenase Deficiency	G6pd Deficiency Glucose-6-Phosphate Dehydrogenase Deficiency Deficiency Of Glucose-6-Phosphate Dehydrogenase Glucose 6 Phosphate Dehydrogenase Deficiency Deficiency Of G-6pd G6pdd
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Lipoid Congenital Adrenal Hyperplasia	Congenital Adrenal Hyperplasia Congenital Lipoid Adrenal Hyperplasia Due To Star Deficency Congenital Lipoid Adrenal Hyperplasia Lipoid Cah Lipoid Adrenal Hyperplasia Adrenal Hyperplasia 1 Cah Clah LCAH Adrenal Hyperplasia I Lipoid Hyperplasia, Congenital, Of Adrenal Cortex With Male Pseudohermaphroditism Congenital Adrenal Hyperplasia Lipoid Adrenal Hyperplasia, Congenital Congenital Adrenal Hyperplasia, Lipoid AH1 Congenital Lipoid Hyperplasia Of Adrenal Cortex With Male Pseudohermaphroditism Adrenal Hyperplasia Congenital Hyperplasia, Adrenal, Lipoid, Congenital Congenital Adrenogenital Disorders Associated With Enzyme Deficiency Congenital Adrenal Cortical Hyperplasia Congenital Adrenal Gland Hyperplasia Congenital Adrenogenital Syndrome Congenital Hyperadrenocorticism Congenital Adrenogenitalism Congenital Female Adrenal Pseudohermaphroditism
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (20)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0376	Liquiritin		99.99%	Unkown
HY-150644	S07-2010		98.35%	Unkown
HY-138557	AKR1C3-IN-4		99.77%	Unkown
HY-W008567	N-Deschlorobenzoyl indomethacin		95.0%	Unkown
HY-W414731	N-(3-Methylphenyl)anthranilic acid		99.82%	Unkown
HY-W069545	(S)-1-Tetralol		99.75%	Unkown
HY-121656	AKR1C2/3-IN-2	Inhibitor	/	Unkown
HY-123732	CRT0083914		/	Unkown
HY-146573	AKR1C3-IN-6		/	Unkown
HY-161839	AKR1C2/3-IN-1		/	Unkown
HY-163609	PROTAC AKR1C3 degrader-1	Degrader	/	Unkown
HY-173132	AKR1Cs-IN-1		/	Unkown
HY-181542	SG-55		/	Unkown
HY-184927	S34-1035	Inhibitor	/	Unkown
HY-184928	S34-1040	Inhibitor	/	Unkown
HY-N0376R	Liquiritin (Standard)		/	Unkown
HY-RS00535	AKR1C2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W706737	N-Deschlorobenzoyl indomethacin-d3		/	Unkown
HY-124432	CRT0093964	Inhibitor	/	Unkown
HY-RS24021	Akr1c2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	AKR1C2	RGD	RGD:1311841
Others	AKR1C2	NCBI