PARP15 - poly(ADP-ribose) polymerase family member 15 Gene

Also Known as BAL3; ARTD7; pART7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 165631

About PARP15

Cytogenetic location: 3q21.1 Genomic coordinates (GRCh38): 3:122,577,650-122,639,047 (from NCBI)

This gene has 6 transcripts (splice variants), 449 orthologues and 8 paralogues. Biased expression in spleen (RPKM 9.7), lymph node (RPKM 8.3) and 8 other tissues.

Summary

PARP15 is a macrodomain-containing transcriptional repressor with poly(ADP-ribose) polymerase activity (Aguiar et al., 2005 [PubMed 16061477]).[supplied by OMIM, May 2008]

PARP15 Products (17)

mRNA Protein Name
XM_017005792.3 XP_016861281.1 protein mono-ADP-ribosyltransferase PARP15 isoform X9
XM_047447582.1 XP_047303538.1 protein mono-ADP-ribosyltransferase PARP15 isoform X8
XM_005247159.5 XP_005247216.1 protein mono-ADP-ribosyltransferase PARP15 isoform X3
XM_011512476.4 XP_011510778.1 protein mono-ADP-ribosyltransferase PARP15 isoform X2
NM_001308321.2 NP_001295250.1 protein mono-ADP-ribosyltransferase PARP15 isoform 4 precursor
XM_047447583.1 XP_047303539.1 protein mono-ADP-ribosyltransferase PARP15 isoform X9
XM_011512479.4 XP_011510781.1 protein mono-ADP-ribosyltransferase PARP15 isoform X9
XM_047447580.1 XP_047303536.1 protein mono-ADP-ribosyltransferase PARP15 isoform X5
XM_011512475.4 XP_011510777.1 protein mono-ADP-ribosyltransferase PARP15 isoform X1
XM_005247160.5 XP_005247217.1 protein mono-ADP-ribosyltransferase PARP15 isoform X4
NM_001113523.3 NP_001106995.1 protein mono-ADP-ribosyltransferase PARP15 isoform 1
XM_047447584.1 XP_047303540.1 protein mono-ADP-ribosyltransferase PARP15 isoform X10
XM_011512480.4 XP_011510782.1 protein mono-ADP-ribosyltransferase PARP15 isoform X11
XM_017005791.3 XP_016861280.1 protein mono-ADP-ribosyltransferase PARP15 isoform X7
NM_001308320.2 NP_001295249.1 protein mono-ADP-ribosyltransferase PARP15 isoform 3
NM_152615.3 NP_689828.1 protein mono-ADP-ribosyltransferase PARP15 isoform 2 precursor
XM_011512477.4 XP_011510779.1 protein mono-ADP-ribosyltransferase PARP15 isoform X6

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables NAD+ binding IMP
IMP: Inferred from mutant phenotype
16061477 GOA
enables NAD+-protein ADP-ribosyltransferase activity IDA
IDA: Inferred from direct assay
25043379 GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity IMP
IMP: Inferred from mutant phenotype
16061477 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23473667 GOA
enables transcription corepressor activity IMP
IMP: Inferred from mutant phenotype
16061477 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
16061477 GOA
involved in protein poly-ADP-ribosylation IMP
IMP: Inferred from mutant phenotype
16061477 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PARP15 Protein Structure

Macro

Macro: Macro domain (107 - 221)

Macro

Macro: Macro domain (322 - 416)

PARP

PARP: Poly(ADP-ribose) polymerase catalytic domain (496 - 676)

  • 0
  • 200
  • 400
  • 600
  • 678 a.a.
Protein Preferred Names Protein Names

protein mono-ADP-ribosyltransferase PARP15

  • ADP-ribosyltransferase diphtheria toxin-like 7

  • B-aggressive lymphoma 3

  • B-aggressive lymphoma protein 3

  • PARP-15

  • poly [ADP-ribose] polymerase 15

Related Diseases

Diseases Alias
Yaws

  • Frambesia

  • Frambesia Tropica

  • Bouba

  • Frambosie

  • Polypapilloma Tropicum

  • Thymosis

  • Endemic Treponematoses

  • Treponema Pertenue Infection

  • Pian

  • Framboesia

  • Framboesia Tropica

  • Castellani

  • Infection By Treponema Pertenue

  • Parangi

  • Framboesioma

  • Chancre Of Yaws

  • Primary Framboesia

  • Initial Lesions Of Yaws

  • Mother Yaw

  • Initial Framboesia
Bejel

  • Njovera

  • Dichuchwa

  • Nonvenereal Endemic Syphilis

  • Endemic Syphilis

  • Frenga

  • Nonvenereal Syphilis

  • Treponemal Infections

  • Non-Venereal Endemic Syphilis

  • Siti

  • Skerljevo

  • Belesh
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-150207 RBN-3143 Inhibitor 99.29% Phase 1

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148566 OUL232 Inhibitor 99.86% Unkown
HY-143398 PARP10/15-IN-1 Inhibitor 95.04% Unkown
HY-148754 PARP10-IN-3 Inhibitor 98.72% Unkown
HY-146502 PARP10/15-IN-3 Inhibitor 99.23% Unkown
HY-148753 PARP10-IN-2 Inhibitor 98.07% Unkown
HY-155993 YCH1899 Inhibitor 99.39% Unkown
HY-121719 TIQ-A Inhibitor 99.85% Unkown
HY-146501 PARP10/15-IN-2 Inhibitor 98.92% Unkown
HY-143338 ART-IN-1 Inhibitor 98.91% Unkown
HY-172806 PARP14 inhibitor 1 Inhibitor / Unkown
HY-148709 ARTD10/PARP10-IN-1 Inhibitor / Unkown
HY-148710 ARTD10/PARP10-IN-2 Inhibitor / Unkown
HY-W294889 OUL245 Inhibitor / Unkown