Kpna1 - karyopherin (importin) alpha 1 Gene

Also Known as NPI1; Rch2; IPOA5; mSRP1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16646

Summary

Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Involved in postsynapse to nucleus signaling pathway. Acts upstream of or within several processes, including NLS-bearing protein import into nucleus; satellite cell activation involved in skeletal muscle regeneration; and skeletal muscle satellite cell proliferation. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including central nervous system; genitourinary system; gut; integumental system; and sensory organ. Orthologous to human KPNA1 (karyopherin subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]

Kpna1 Products (1)

mRNA Protein Name
NM_008465.5 NP_032491.2 importin subunit alpha-5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18716025 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within NLS-bearing protein import into nucleus IMP
IMP: Inferred from mutant phenotype
27434733 MGI
involved in postsynapse to nucleus signaling pathway IDA
IDA: Inferred from direct assay
15603742 MGI
acts upstream of or within regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
27434733 MGI
acts upstream of or within regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
27434733 MGI
acts upstream of or within satellite cell activation involved in skeletal muscle regeneration IMP
IMP: Inferred from mutant phenotype
27434733 MGI
acts upstream of or within skeletal muscle satellite cell proliferation IMP
IMP: Inferred from mutant phenotype
27434733 MGI
acts upstream of or within skeletal muscle tissue regeneration IMP
IMP: Inferred from mutant phenotype
27434733 MGI
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
15603742 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
15603742 MGI
is active in postsynaptic density IDA
IDA: Inferred from direct assay
15603742 MGI
is active in postsynaptic density IEP
IEP: Inferred from expression pattern
15603742 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

importin subunit alpha-5

  • NPI-1

  • RAG cohort protein 2

  • SRP1-beta

  • importin alpha 5

  • importin alpha-S1

  • importin subunit alpha-1

  • karyopherin subunit alpha-1

  • m-importin-alpha-S1

  • nucleoprotein interactor 1

Kpna1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Kpna1 Q60960 SF1 Homo sapiens Q15637
Y2H Fragment Pooling
26420826
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS22602 Kpna1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07415 KPNA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29118 Kpna1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kpna1 NCBI NCBI:3836