Lamp2 - lysosomal-associated membrane protein 2 Gene

Also Known as Mac3; LGP-B; CD107b; Lamp-2; Lamp II; Lamp-2a; Lamp-2b; Lamp-2c

Species: Mus musculus

Gene Type: protein coding

Gene ID: 16784

Summary

Enables protein domain specific binding activity. Involved in several processes, including autophagosome maturation; protein stabilization; and protein targeting to lysosome involved in chaperone-mediated Autophagy. Acts upstream of or within muscle cell cellular homeostasis. Located in late endosome membrane; lysosomal membrane; and phagocytic vesicle membrane. Is integral component of autophagosome membrane. Is expressed in central nervous system; egg cylinder; lung; and retina. Used to study Danon disease. Human ortholog(s) of this gene implicated in Danon disease and hypertrophic cardiomyopathy. Orthologous to human LAMP2 (lysosomal associated membrane protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Lamp2 Products (3)

mRNA	Protein	Name
NM_001017959.2	NP_001017959.1	lysosome-associated membrane glycoprotein 2 isoform 1 precursor
NM_001290485.2	NP_001277414.1	lysosome-associated membrane glycoprotein 2 isoform 3 precursor
NM_010685.4	NP_034815.2	lysosome-associated membrane glycoprotein 2 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21194361	MGI
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	22641697	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in autophagosome maturation	IMP IMP: Inferred from mutant phenotype	27628032	MGI
involved in autophagy	IMP IMP: Inferred from mutant phenotype	12221139	MGI
involved in cellular response to starvation	IMP IMP: Inferred from mutant phenotype	27628032	MGI
involved in chaperone-mediated autophagy	IGI IGI: Inferred from genetic interaction	18644871	MGI
acts upstream of or within chaperone-mediated autophagy	IMP IMP: Inferred from mutant phenotype	18579532	MGI
involved in chaperone-mediated autophagy	IMP IMP: Inferred from mutant phenotype	27628032	MGI
acts upstream of or within muscle cell cellular homeostasis	IMP IMP: Inferred from mutant phenotype	20060297	MGI
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	22641697	MGI
involved in protein targeting	IMP IMP: Inferred from mutant phenotype	12221139	MGI
involved in protein targeting to lysosome involved in chaperone-mediated autophagy	IMP IMP: Inferred from mutant phenotype	27628032	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in autophagosome membrane	IDA IDA: Inferred from direct assay	12221139	MGI
located in late endosome	IDA IDA: Inferred from direct assay	14668490	MGI
located in late endosome membrane	IDA IDA: Inferred from direct assay	21896273	MGI
located in lysosomal membrane	IDA IDA: Inferred from direct assay	18022370	MGI
is active in lysosome	IDA IDA: Inferred from direct assay	17185018	MGI
located in lysosome	IDA IDA: Inferred from direct assay	12775715	MGI
located in phagocytic vesicle membrane	IMP IMP: Inferred from mutant phenotype	9670047	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
lysosome-associated membrane glycoprotein 2	CD107 antigen-like family member B lysosomal membrane glycoprotein 2 lysosomal membrane glycoprotein type B

Recombinant Lamp2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74781	LAMP2/CD107b Protein, Mouse (HEK293, His)	P17047 (L26-N379)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-134923	CA77.1	Inducer	99.92%	Unkown
HY-112483	QX77	Inducer	99.48%	Unkown
HY-184300	PDL1 degrader-4	Degrader	/	Unkown
HY-RS07510	LAMP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17112	Lamp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23557	Lamp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lamp2	NCBI	NCBI:3920